FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3187560971> ?p ?o ?g. }

• W3187560971 endingPage "215" @default.
• W3187560971 startingPage "204" @default.
• W3187560971 abstract "Cystic Fibrosis (CF) is caused by loss of function mutations in the Cystic Fibrosis transmembrane conductance regulator (CFTR). The folding and assembly of CFTR is inefficient. Deletion of F508 in the first nucleotide binding domain (NBD1-ΔF508) further disrupts protein stability leading to endoplasmic reticulum retention and proteasomal degradation. Stabilization and prevention of NBD1-ΔF508 aggregation is critical to rescuing the folding and function of the entire CFTR channel. We report that the phenolic compounds Oleuropein and Hydroxytryosol reduce aggregation of NBD1-ΔF508. The NBD1-ΔF508 aggregate size was smaller in the presence of Hydroxytryosol as determined by dynamic light scattering. Neither phenolic compound increased the thermal stability of NBD1-ΔF508 as measured by differential scanning fluorimetry. Interestingly, Hydroxytyrosol inhibited the stabilizing effect of the indole compound BIA, a known stabilizer, on NBD1-ΔF508. Molecular docking studies predicted that Oleuropein preferred to bind in the F1-type core ATP-binding subdomain in NBD1. In contrast, Hydroxytyrosol preferred to bind in the α4/α5/α6 helical bundle of the ABCα subdomain of NBD1 next to the putative binding site for BIA. This result suggests that Hydroxytyrosol interferes with BIA binding, thus providing an explanation for the antagonistic effect on NBD1 stability upon incubation with both compounds. To our knowledge, these studies are the first to explore the effects of these two phenolic compounds on the aggregation and stability of NBD1-ΔF508 domain of CFTR." @default.
• W3187560971 created "2021-08-16" @default.
• W3187560971 creator A5001101670 @default.
• W3187560971 creator A5003909383 @default.
• W3187560971 creator A5023499164 @default.
• W3187560971 creator A5040162306 @default.
• W3187560971 creator A5056154257 @default.
• W3187560971 date "2021-08-04" @default.
• W3187560971 modified "2023-10-16" @default.
• W3187560971 title "Differential Effects of Oleuropein and Hydroxytyrosol on Aggregation and Stability of CFTR NBD1-ΔF508 Domain" @default.
• W3187560971 cites W1602887917 @default.
• W3187560971 cites W1896236092 @default.
• W3187560971 cites W1909885591 @default.
• W3187560971 cites W1966528069 @default.
• W3187560971 cites W1966630491 @default.
• W3187560971 cites W1989101763 @default.
• W3187560971 cites W1991384225 @default.
• W3187560971 cites W1995692151 @default.
• W3187560971 cites W2018414056 @default.
• W3187560971 cites W2032141646 @default.
• W3187560971 cites W2039599894 @default.
• W3187560971 cites W2044328480 @default.
• W3187560971 cites W2045848640 @default.
• W3187560971 cites W2047623797 @default.
• W3187560971 cites W2065283382 @default.
• W3187560971 cites W2066266956 @default.
• W3187560971 cites W2066722784 @default.
• W3187560971 cites W2067463439 @default.
• W3187560971 cites W2071407356 @default.
• W3187560971 cites W2079234445 @default.
• W3187560971 cites W2099245798 @default.
• W3187560971 cites W2101078720 @default.
• W3187560971 cites W2104066268 @default.
• W3187560971 cites W2109732625 @default.
• W3187560971 cites W2110939349 @default.
• W3187560971 cites W2134097876 @default.
• W3187560971 cites W2139398847 @default.
• W3187560971 cites W2151837778 @default.
• W3187560971 cites W2158288696 @default.
• W3187560971 cites W2161849629 @default.
• W3187560971 cites W2171278423 @default.
• W3187560971 cites W2287783115 @default.
• W3187560971 cites W2509843246 @default.
• W3187560971 cites W2528866509 @default.
• W3187560971 cites W2618831618 @default.
• W3187560971 cites W2765546463 @default.
• W3187560971 cites W2791762792 @default.
• W3187560971 cites W2807364537 @default.
• W3187560971 cites W2808341670 @default.
• W3187560971 cites W2884160427 @default.
• W3187560971 cites W2906935376 @default.
• W3187560971 cites W2939725363 @default.
• W3187560971 cites W2945470910 @default.
• W3187560971 cites W2989708402 @default.
• W3187560971 cites W2998785333 @default.
• W3187560971 cites W3136379455 @default.
• W3187560971 cites W4241473661 @default.
• W3187560971 cites W653435503 @default.
• W3187560971 doi "https://doi.org/10.3390/jor1030019" @default.
• W3187560971 hasPublicationYear "2021" @default.
• W3187560971 type Work @default.
• W3187560971 sameAs 3187560971 @default.
• W3187560971 citedByCount "0" @default.
• W3187560971 crossrefType "journal-article" @default.
• W3187560971 hasAuthorship W3187560971A5001101670 @default.
• W3187560971 hasAuthorship W3187560971A5003909383 @default.
• W3187560971 hasAuthorship W3187560971A5023499164 @default.
• W3187560971 hasAuthorship W3187560971A5040162306 @default.
• W3187560971 hasAuthorship W3187560971A5056154257 @default.
• W3187560971 hasBestOaLocation W31875609711 @default.
• W3187560971 hasConcept C104317684 @default.
• W3187560971 hasConcept C113027372 @default.
• W3187560971 hasConcept C149011108 @default.
• W3187560971 hasConcept C158617107 @default.
• W3187560971 hasConcept C167625842 @default.
• W3187560971 hasConcept C185592680 @default.
• W3187560971 hasConcept C2775881703 @default.
• W3187560971 hasConcept C2777893369 @default.
• W3187560971 hasConcept C2777957096 @default.
• W3187560971 hasConcept C2778004101 @default.
• W3187560971 hasConcept C2778428886 @default.
• W3187560971 hasConcept C44312359 @default.
• W3187560971 hasConcept C55493867 @default.
• W3187560971 hasConcept C70899900 @default.
• W3187560971 hasConceptScore W3187560971C104317684 @default.
• W3187560971 hasConceptScore W3187560971C113027372 @default.
• W3187560971 hasConceptScore W3187560971C149011108 @default.
• W3187560971 hasConceptScore W3187560971C158617107 @default.
• W3187560971 hasConceptScore W3187560971C167625842 @default.
• W3187560971 hasConceptScore W3187560971C185592680 @default.
• W3187560971 hasConceptScore W3187560971C2775881703 @default.
• W3187560971 hasConceptScore W3187560971C2777893369 @default.
• W3187560971 hasConceptScore W3187560971C2777957096 @default.
• W3187560971 hasConceptScore W3187560971C2778004101 @default.
• W3187560971 hasConceptScore W3187560971C2778428886 @default.
• W3187560971 hasConceptScore W3187560971C44312359 @default.
• W3187560971 hasConceptScore W3187560971C55493867 @default.
• W3187560971 hasConceptScore W3187560971C70899900 @default.

• next