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• W3187683696 endingPage "101034" @default.
• W3187683696 startingPage "101034" @default.
• W3187683696 abstract "Synaptic plasticity is critical for brain function, including learning and memory. It is regulated by gene transcription and protein synthesis as well as posttranslational modifications at synapses. Although protein acetylation has been shown to be involved in the regulation of synaptic plasticity, this was mainly for histone protein acetylation. To investigate whether acetylation of nonhistone proteins is important for synaptic plasticity, we analyzed mouse brain acetylome and found that calmodulin (CaM), a ubiquitous Ca2+ sensor, was acetylated on three lysine residues, which were conserved across species. NMDA receptor-dependent long-term potentiation (LTP) is considered the most compelling form of synaptic plasticity. During LTP induction, activation of NMDA receptor triggers Ca2+ influx, and the Ca2+ binds with CaM and activates calcium/calmodulin-dependent protein kinase IIα (CaMKIIα), which is essential for LTP induction. By using home-generated and site-specific antibodies against acetylated CaM, we show that CaM acetylation is upregulated by neural activities in an NMDA receptor-dependent manner. Moreover, mutation of acetyllysines in CaM1 proteins disrupts synaptic plasticity and fear learning in a mouse model. We further demonstrate that acetylation of CaM reduces the binding free energy and increases the binding affinity toward CaMKIIα, a protein kinase pivotal to synaptic plasticity and learning. Taken together, our results demonstrate importance of CaM acetylation in regulating synaptic plasticity and learning." @default.
• W3187683696 created "2021-08-16" @default.
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• W3187683696 date "2021-09-01" @default.
• W3187683696 modified "2023-09-30" @default.
• W3187683696 title "Acetylation of calmodulin regulates synaptic plasticity and fear learning" @default.
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• W3187683696 cites W1703928766 @default.
• W3187683696 cites W1967046995 @default.
• W3187683696 cites W1969155399 @default.
• W3187683696 cites W1974883532 @default.
• W3187683696 cites W1976283234 @default.
• W3187683696 cites W1978155331 @default.
• W3187683696 cites W1983523416 @default.
• W3187683696 cites W1996234811 @default.
• W3187683696 cites W1996744375 @default.
• W3187683696 cites W2002671660 @default.
• W3187683696 cites W2002932881 @default.
• W3187683696 cites W2004827874 @default.
• W3187683696 cites W2005072759 @default.
• W3187683696 cites W2009826707 @default.
• W3187683696 cites W2010424836 @default.
• W3187683696 cites W2013115334 @default.
• W3187683696 cites W2029130907 @default.
• W3187683696 cites W2029169169 @default.
• W3187683696 cites W2029903254 @default.
• W3187683696 cites W2034424952 @default.
• W3187683696 cites W2035550082 @default.
• W3187683696 cites W2037069728 @default.
• W3187683696 cites W2042966900 @default.
• W3187683696 cites W2046033738 @default.
• W3187683696 cites W2046459630 @default.
• W3187683696 cites W2049511526 @default.
• W3187683696 cites W2050066016 @default.
• W3187683696 cites W2051493425 @default.
• W3187683696 cites W2052322593 @default.
• W3187683696 cites W2052366943 @default.
• W3187683696 cites W2052858356 @default.
• W3187683696 cites W2072106835 @default.
• W3187683696 cites W2080640632 @default.
• W3187683696 cites W2082541302 @default.
• W3187683696 cites W2087714970 @default.
• W3187683696 cites W2088093088 @default.
• W3187683696 cites W2090760765 @default.
• W3187683696 cites W2092722802 @default.
• W3187683696 cites W2101065953 @default.
• W3187683696 cites W2109026370 @default.
• W3187683696 cites W2118052892 @default.
• W3187683696 cites W2128834282 @default.
• W3187683696 cites W2130151244 @default.
• W3187683696 cites W2132622900 @default.
• W3187683696 cites W2132971431 @default.
• W3187683696 cites W2139087276 @default.
• W3187683696 cites W2140201388 @default.
• W3187683696 cites W2148129999 @default.
• W3187683696 cites W2149462562 @default.
• W3187683696 cites W2158747282 @default.
• W3187683696 cites W2170774618 @default.
• W3187683696 cites W2313116527 @default.
• W3187683696 cites W2418351874 @default.
• W3187683696 cites W2513112263 @default.
• W3187683696 cites W2560764475 @default.
• W3187683696 cites W2562099827 @default.
• W3187683696 cites W2600293296 @default.
• W3187683696 cites W2735674872 @default.
• W3187683696 cites W2745223926 @default.
• W3187683696 cites W2748043294 @default.
• W3187683696 cites W2804432738 @default.
• W3187683696 cites W2885927965 @default.
• W3187683696 cites W2894941693 @default.
• W3187683696 cites W2901164269 @default.
• W3187683696 cites W2916268207 @default.
• W3187683696 cites W2919162898 @default.
• W3187683696 cites W2921756914 @default.
• W3187683696 cites W3004628053 @default.
• W3187683696 cites W3025713031 @default.
• W3187683696 cites W3134329272 @default.
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• W3187683696 doi "https://doi.org/10.1016/j.jbc.2021.101034" @default.
• W3187683696 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8383114" @default.
• W3187683696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34339735" @default.
• W3187683696 hasPublicationYear "2021" @default.
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