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- W3187769147 endingPage "781" @default.
- W3187769147 startingPage "781" @default.
- W3187769147 abstract "<ns4:p>Oligodendrocytes wrap multiple lamellae of their membrane, myelin, around axons of the central nervous system (CNS), to improve impulse conduction. Myelin synthesis is specialised and dynamic, responsive to local neuronal excitation. Subtle pathological insults are sufficient to cause significant neuronal metabolic impairment, so myelin preservation is necessary to safeguard neural networks. Multiple sclerosis (MS) is the most prevalent demyelinating disease of the CNS. In MS, inflammatory attacks against myelin, proposed to be autoimmune, cause myelin decay and oligodendrocyte loss, leaving neurons vulnerable. Current therapies target the prominent neuroinflammation but are mostly ineffective in protecting from neurodegeneration and the progressive neurological disability. People with MS have substantially higher levels of extracellular glutamate, the main excitatory neurotransmitter. This impairs cellular homeostasis to cause excitotoxic stress. Large conductance Ca2<ns4:sup>+</ns4:sup>-activated K<ns4:sup>+ </ns4:sup>channels (BK channels) could preserve myelin or allow its recovery by protecting cells from the resulting excessive excitability. This review evaluates the role of excitotoxic stress, myelination and BK channels in MS pathology, and explores the hypothesis that BK channel activation could be a therapeutic strategy to protect oligodendrocytes from excitotoxic stress in MS. This could reduce progression of neurological disability if used in parallel to immunomodulatory therapies.</ns4:p>" @default.
- W3187769147 created "2021-08-16" @default.
- W3187769147 creator A5016912802 @default.
- W3187769147 creator A5026824813 @default.
- W3187769147 creator A5073638714 @default.
- W3187769147 date "2021-08-09" @default.
- W3187769147 modified "2023-10-17" @default.
- W3187769147 title "Oligodendrocytes, BK channels and remyelination" @default.
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