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- W3187875010 abstract "A recent paper by Doi et al. advocated completely replacing the relative risk (RR) with the odds ratio (OR) as the effect measure in clinical trials and meta-analyses with binary outcomes. Besides some practical advantages of RR over OR, Doi et al.'s key assumption that the OR is portable in the meta-analysis, that is, study-specific ORs are likely not correlated with baseline risks, was not well justified.We summarized Spearman's rank correlation coefficient between study-specific ORs and baseline risks in 40,243 meta-analyses from the Cochrane Database of Systematic Reviews.Study-specific ORs tend to be higher in studies with lower baseline risks of disease for most meta-analyses in Cochrane Database of Systematic Reviews. Using an actual meta-analysis example, we demonstrate that there is a strong negative correlation between OR (RR or RD) with the baseline risk and the conditional effects notably vary with baseline risks.Replacing RR or RD with OR is currently unadvisable in clinical trials and meta-analyses. It is possible that no effect measure is portable in a meta-analysis. In addition to the overall (or marginal) effect, we suggest presenting the conditional effect based on the baseline risk using a bivariate generalized linear mixed model." @default.
- W3187875010 created "2021-08-16" @default.
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- W3187875010 date "2022-02-01" @default.
- W3187875010 modified "2023-10-17" @default.
- W3187875010 title "Controversy and Debate: Questionable utility of the relative risk in clinical research: Paper 2: Is the Odds Ratio “portable” in meta-analysis? Time to consider bivariate generalized linear mixed model" @default.
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- W3187875010 doi "https://doi.org/10.1016/j.jclinepi.2021.08.004" @default.
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