FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3187900120> ?p ?o ?g. }

• W3187900120 startingPage "2866" @default.
• W3187900120 abstract "Abstract Introduction: During the last decade, single nucleotide polymorphisms (SNPs) on the chromosomal locus 9p21 have been associated with several cardiovascular (CV) diseases, such as stroke and myocardial infarction. In this study, we evaluated the association between two SNPs on 9p21 and Chronic Myeloid Leukemia (CML). As CML is generally treated with tyrosine kinase inhibitors (TKIs) and TKI therapy has been associated with increased vascular events by itself, we investigated the influence of SNPs on chromosome 9p21 on the incidence of CV events in subjects affected by CML who were in treatment with TKIs. Patients and Methods: We studied 185 patients with CML and 171 unaffected controls. The median age at the diagnosis of CML was 55 years (range 17-84) and we enrolled 99 males and 86 females. All patients were treated with at least 1 TKI, with Imatinib being the most commonly used as first line therapy (71%). Previous CV diseases were taken into account and new CV events were recorded during follow-up. The median follow-up was 91,5 months (range 14-301). Genomic DNA was isolated from peripheral blood collected during follow-up and the rs1333040C>T and rs7865618A>G polymorphisms were assessed by PCR-RFLP using restriction endonucleases. For each SNP, we performed dominant, recessive, and additive genetic models. The association between SNPs on 9p21 and CML was evaluated using Chi-square test. In subjects affected by CML, to study the association between SNPs on 9p21 and CV events, Fisher's exact test was performed. In CML patients we also analyzed the correlation between SNP on 9p21 and age at diagnosis, sex, ethnic group, Sokal, Euro and Eutos risk, response to therapy. Results: The distribution of the three possible genotypes of rs1333040 (TT, TC and CC) was statistically different between cases and controls (p=0.0006; Table 1). The TT genotype was significantly associated with CML in the dominant model (p=0.0001) but not in the recessive model (p=0.09). The T allele was significantly associated with CML in the additive model (p=0.004). Also, the distribution of the three possible genotypes of rs7865618 (GG, AG and AA) was statistically different between cases and controls (p=0.015; Table 2), and the GG genotype and the G allele were significantly associated with CML in the dominant (p=0.05), recessive (p=0.009), and additive models (p=0.009). We registered 37 CV events among patients affected by CML. Most of them (26) occurred before the introduction of TKI therapy. In patients taking TKI, 11 events were recorded. The TT genotype of rs1333040 was associated with an increased risk of CV events in CML patients (p=0.05) with no difference between patients taking or not taking TKI. Differently, patients carrying the “at risk” genotype of rs7865618 (GG) did not show increased risk of CV events compared to the control population. No correlation was found between CML patients characteristics and response to therapy and studied genotypes. Discussion: Polymorphisms on chromosome 9p21 have been consistently associated with CV diseases in the general population. In this study, we demonstrate that the TT genotype of rs1333040 and the GG genotype of rs7865618 are significantly associated with CML. Patients affected by CML who are carriers of the TT genotype of rs1333040 show increased risk of CV events compared with non-carriers. The use of TKIs is not associated with increased risk of CV events in both carriers and non-carriers. The 9p21 chromosomal region deserves further investigation for its potential role in the genetic susceptibility to CML and associated CV events. Download : Download high-res image (115KB) Download : Download full-size image Disclosures Abruzzese: Bristol Myers Squibb: Consultancy; Pfizer: Consultancy; Incyte: Consultancy; ARIAD: Consultancy; Novartis: Consultancy." @default.
• W3187900120 created "2021-08-16" @default.
• W3187900120 creator A5025658524 @default.
• W3187900120 creator A5028160176 @default.
• W3187900120 creator A5032920108 @default.
• W3187900120 creator A5033482554 @default.
• W3187900120 creator A5034125483 @default.
• W3187900120 creator A5042424261 @default.
• W3187900120 creator A5045565716 @default.
• W3187900120 creator A5061902084 @default.
• W3187900120 creator A5071213712 @default.
• W3187900120 creator A5078295126 @default.
• W3187900120 date "2017-12-08" @default.
• W3187900120 modified "2023-10-02" @default.
• W3187900120 title "Association between 9p21 Chromosome Polymorphisms rs1333040 and rs7865618 and Chronic Myeloid Leukemia" @default.
• W3187900120 doi "https://doi.org/10.1182/blood.v130.suppl_1.2866.2866" @default.
• W3187900120 hasPublicationYear "2017" @default.
• W3187900120 type Work @default.
• W3187900120 sameAs 3187900120 @default.
• W3187900120 citedByCount "0" @default.
• W3187900120 crossrefType "journal-article" @default.
• W3187900120 hasAuthorship W3187900120A5025658524 @default.
• W3187900120 hasAuthorship W3187900120A5028160176 @default.
• W3187900120 hasAuthorship W3187900120A5032920108 @default.
• W3187900120 hasAuthorship W3187900120A5033482554 @default.
• W3187900120 hasAuthorship W3187900120A5034125483 @default.
• W3187900120 hasAuthorship W3187900120A5042424261 @default.
• W3187900120 hasAuthorship W3187900120A5045565716 @default.
• W3187900120 hasAuthorship W3187900120A5061902084 @default.
• W3187900120 hasAuthorship W3187900120A5071213712 @default.
• W3187900120 hasAuthorship W3187900120A5078295126 @default.
• W3187900120 hasConcept C104317684 @default.
• W3187900120 hasConcept C126322002 @default.
• W3187900120 hasConcept C135763542 @default.
• W3187900120 hasConcept C143998085 @default.
• W3187900120 hasConcept C153209595 @default.
• W3187900120 hasConcept C191093355 @default.
• W3187900120 hasConcept C2777583451 @default.
• W3187900120 hasConcept C2778729363 @default.
• W3187900120 hasConcept C2780189214 @default.
• W3187900120 hasConcept C3019892230 @default.
• W3187900120 hasConcept C30481170 @default.
• W3187900120 hasConcept C53226629 @default.
• W3187900120 hasConcept C54355233 @default.
• W3187900120 hasConcept C71924100 @default.
• W3187900120 hasConcept C86803240 @default.
• W3187900120 hasConcept C90924648 @default.
• W3187900120 hasConceptScore W3187900120C104317684 @default.
• W3187900120 hasConceptScore W3187900120C126322002 @default.
• W3187900120 hasConceptScore W3187900120C135763542 @default.
• W3187900120 hasConceptScore W3187900120C143998085 @default.
• W3187900120 hasConceptScore W3187900120C153209595 @default.
• W3187900120 hasConceptScore W3187900120C191093355 @default.
• W3187900120 hasConceptScore W3187900120C2777583451 @default.
• W3187900120 hasConceptScore W3187900120C2778729363 @default.
• W3187900120 hasConceptScore W3187900120C2780189214 @default.
• W3187900120 hasConceptScore W3187900120C3019892230 @default.
• W3187900120 hasConceptScore W3187900120C30481170 @default.
• W3187900120 hasConceptScore W3187900120C53226629 @default.
• W3187900120 hasConceptScore W3187900120C54355233 @default.
• W3187900120 hasConceptScore W3187900120C71924100 @default.
• W3187900120 hasConceptScore W3187900120C86803240 @default.
• W3187900120 hasConceptScore W3187900120C90924648 @default.
• W3187900120 hasLocation W31879001201 @default.
• W3187900120 hasOpenAccess W3187900120 @default.
• W3187900120 hasPrimaryLocation W31879001201 @default.
• W3187900120 hasRelatedWork W137490473 @default.
• W3187900120 hasRelatedWork W1994378980 @default.
• W3187900120 hasRelatedWork W2133669108 @default.
• W3187900120 hasRelatedWork W2315661423 @default.
• W3187900120 hasRelatedWork W2335227877 @default.
• W3187900120 hasRelatedWork W2356468612 @default.
• W3187900120 hasRelatedWork W2522993475 @default.
• W3187900120 hasRelatedWork W2583578499 @default.
• W3187900120 hasRelatedWork W2588356576 @default.
• W3187900120 hasRelatedWork W2622665072 @default.
• W3187900120 hasRelatedWork W2748860563 @default.
• W3187900120 hasRelatedWork W2788645458 @default.
• W3187900120 hasRelatedWork W2907201486 @default.
• W3187900120 hasRelatedWork W2934528750 @default.
• W3187900120 hasRelatedWork W2965933257 @default.
• W3187900120 hasRelatedWork W2979830597 @default.
• W3187900120 hasRelatedWork W3029031276 @default.
• W3187900120 hasRelatedWork W3114681987 @default.
• W3187900120 hasRelatedWork W3126948065 @default.
• W3187900120 hasRelatedWork W209488978 @default.
• W3187900120 hasVolume "130" @default.
• W3187900120 isParatext "false" @default.
• W3187900120 isRetracted "false" @default.
• W3187900120 magId "3187900120" @default.
• W3187900120 workType "article" @default.