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- W3188182783 abstract "Abstract Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors and urgently requires the development of new therapeutic strategies. In this study, an innovative hybrid in vitro vascularized GBM‐on‐a‐chip model is presented as a strategic integration of microfluidics and 3D bioprinting technologies. The system can recreate the compartmentalized brain tumor microenvironment, comprising the functional blood brain barrier (BBB) and the adjacent 3D perivascular tumor niche, by selectively mimicking physiological shear stress and cell–cell, cell–matrix mechanical interaction. The GBM‐on‐a‐chip model was evaluated under simulated microgravity (µG) condition as a form of mechanical unloading showing a significant cell morphological and mechanotransduction response thereby indicating that gravitational forces play an important role in glioblastoma mechanical regulation. The proposed GBM‐on‐a‐chip represents a meaningful biological tool for further research in cancer mechanobiology and pre‐clinical approach in brain tumor therapy." @default.
- W3188182783 created "2021-08-16" @default.
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- W3188182783 date "2021-08-02" @default.
- W3188182783 modified "2023-10-11" @default.
- W3188182783 title "A 3D‐Bioprinted Vascularized Glioblastoma‐on‐a‐Chip for Studying the Impact of Simulated Microgravity as a Novel Pre‐Clinical Approach in Brain Tumor Therapy" @default.
- W3188182783 cites W1965522214 @default.
- W3188182783 cites W1966720603 @default.
- W3188182783 cites W1968051022 @default.
- W3188182783 cites W1976439848 @default.
- W3188182783 cites W1977645344 @default.
- W3188182783 cites W1980059877 @default.
- W3188182783 cites W1984313685 @default.
- W3188182783 cites W1986868649 @default.
- W3188182783 cites W2002785815 @default.
- W3188182783 cites W2003129478 @default.
- W3188182783 cites W2013520568 @default.
- W3188182783 cites W2014171174 @default.
- W3188182783 cites W2017877299 @default.
- W3188182783 cites W2018616527 @default.
- W3188182783 cites W2032088674 @default.
- W3188182783 cites W2034437737 @default.
- W3188182783 cites W2040022930 @default.
- W3188182783 cites W2051306620 @default.
- W3188182783 cites W2056451525 @default.
- W3188182783 cites W2066482021 @default.
- W3188182783 cites W2076922024 @default.
- W3188182783 cites W2081135553 @default.
- W3188182783 cites W2081560083 @default.
- W3188182783 cites W2081892717 @default.
- W3188182783 cites W2081974959 @default.
- W3188182783 cites W2084256007 @default.
- W3188182783 cites W2087153492 @default.
- W3188182783 cites W2092735785 @default.
- W3188182783 cites W2094788202 @default.
- W3188182783 cites W2099418348 @default.
- W3188182783 cites W2101099825 @default.
- W3188182783 cites W2116088441 @default.
- W3188182783 cites W2119810088 @default.
- W3188182783 cites W2132566055 @default.
- W3188182783 cites W2134873228 @default.
- W3188182783 cites W2139671059 @default.
- W3188182783 cites W2145975509 @default.
- W3188182783 cites W2146337514 @default.
- W3188182783 cites W2149087782 @default.
- W3188182783 cites W2149162919 @default.
- W3188182783 cites W2156122549 @default.
- W3188182783 cites W2208036228 @default.
- W3188182783 cites W2275816640 @default.
- W3188182783 cites W2332615956 @default.
- W3188182783 cites W2426003472 @default.
- W3188182783 cites W2460755825 @default.
- W3188182783 cites W2487615751 @default.
- W3188182783 cites W2525539600 @default.
- W3188182783 cites W2526011086 @default.
- W3188182783 cites W2535471255 @default.
- W3188182783 cites W2593835365 @default.
- W3188182783 cites W2626725994 @default.
- W3188182783 cites W2740294724 @default.
- W3188182783 cites W2781522649 @default.
- W3188182783 cites W2793363299 @default.
- W3188182783 cites W2803361339 @default.
- W3188182783 cites W2803941007 @default.
- W3188182783 cites W2806013815 @default.
- W3188182783 cites W2887545848 @default.
- W3188182783 cites W2900575301 @default.
- W3188182783 cites W2908955968 @default.
- W3188182783 cites W2921139978 @default.
- W3188182783 cites W2922922277 @default.
- W3188182783 cites W2937767865 @default.
- W3188182783 cites W2943300351 @default.
- W3188182783 cites W2945954835 @default.
- W3188182783 cites W2954724391 @default.
- W3188182783 cites W2954979301 @default.
- W3188182783 cites W2979984433 @default.
- W3188182783 cites W2980898062 @default.
- W3188182783 cites W2991205899 @default.
- W3188182783 cites W3003422412 @default.
- W3188182783 cites W3008258085 @default.
- W3188182783 cites W3017983933 @default.
- W3188182783 cites W3027503504 @default.
- W3188182783 cites W3028917492 @default.
- W3188182783 cites W3043542143 @default.
- W3188182783 cites W3048874737 @default.
- W3188182783 cites W3080290323 @default.
- W3188182783 cites W3082210034 @default.
- W3188182783 cites W3107984511 @default.
- W3188182783 cites W4212949515 @default.
- W3188182783 cites W4378836288 @default.
- W3188182783 cites W274441265 @default.
- W3188182783 doi "https://doi.org/10.1002/adtp.202100106" @default.
- W3188182783 hasPublicationYear "2021" @default.
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