Matches in SemOpenAlex for { <https://semopenalex.org/work/W31882050> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W31882050 abstract "Endothelium-derived C-type natriuretic peptide (CNP) possesses several cytoprotective functions that might be key in preventing cardiovascular disease (Ahluwalia & Hobbs [2005] Trends. Pharmacol. Sci., 26, 162). Since many of the vasoprotective effects of CNP are mediated via natriuretic peptide receptor (NPR)-C, this receptor might represent a novel therapeutic target. Thus, we have undertaken a multi-disciplinary drug development programme, incorporating computer modelling, chemical synthesis and cell-based biological screens to generate novel small molecule mimetics of CNP (i.e. NPR-C agonists). Using the NPR-C crystal structure (He et al. [2001] Science, 293, 1657) as a starting point, we have (a) tested fragments of CNP to elucidate which amino acids make fundamental contact with NPR-C; (b) modified the NPR-C antagonist AP-811, retaining the non-peptide region and using pharmacophore searches to replace the peptide component; (c) manipulated the secondary conformation of CNP to replace key functional groups with spatially-similar molecular structures. These strategies have led to the identification of a series of novel, selective, non-peptide NPR-C agonists that have sub-micromolar potency to reverse vasoconstrictor-induced Ca2+ flux in rat isolated vascular smooth muscle cells and relax rat isolated mesenteric arteries in vitro. Such molecules represent an excellent starting point from which to develop NPR-C agonists for the potential treatment of cardiovascular disease. Supported by The Wellcome Trust" @default.
- W31882050 created "2016-06-24" @default.
- W31882050 creator A5001061252 @default.
- W31882050 creator A5001071662 @default.
- W31882050 creator A5008320520 @default.
- W31882050 creator A5017070659 @default.
- W31882050 creator A5023482793 @default.
- W31882050 creator A5026724212 @default.
- W31882050 creator A5027760107 @default.
- W31882050 creator A5049470577 @default.
- W31882050 creator A5063653314 @default.
- W31882050 creator A5074122662 @default.
- W31882050 creator A5087587235 @default.
- W31882050 date "2009-04-01" @default.
- W31882050 modified "2023-09-23" @default.
- W31882050 title "Design and development of novel non‐peptide agonists at natriuretic peptide receptor‐C" @default.
- W31882050 doi "https://doi.org/10.1096/fasebj.23.1_supplement.756.8" @default.
- W31882050 hasPublicationYear "2009" @default.
- W31882050 type Work @default.
- W31882050 sameAs 31882050 @default.
- W31882050 citedByCount "0" @default.
- W31882050 crossrefType "journal-article" @default.
- W31882050 hasAuthorship W31882050A5001061252 @default.
- W31882050 hasAuthorship W31882050A5001071662 @default.
- W31882050 hasAuthorship W31882050A5008320520 @default.
- W31882050 hasAuthorship W31882050A5017070659 @default.
- W31882050 hasAuthorship W31882050A5023482793 @default.
- W31882050 hasAuthorship W31882050A5026724212 @default.
- W31882050 hasAuthorship W31882050A5027760107 @default.
- W31882050 hasAuthorship W31882050A5049470577 @default.
- W31882050 hasAuthorship W31882050A5063653314 @default.
- W31882050 hasAuthorship W31882050A5074122662 @default.
- W31882050 hasAuthorship W31882050A5087587235 @default.
- W31882050 hasConcept C126322002 @default.
- W31882050 hasConcept C170493617 @default.
- W31882050 hasConcept C178790620 @default.
- W31882050 hasConcept C185592680 @default.
- W31882050 hasConcept C2775915353 @default.
- W31882050 hasConcept C2776885963 @default.
- W31882050 hasConcept C2778198053 @default.
- W31882050 hasConcept C2778938600 @default.
- W31882050 hasConcept C2779281246 @default.
- W31882050 hasConcept C2779395532 @default.
- W31882050 hasConcept C2780189551 @default.
- W31882050 hasConcept C2992686903 @default.
- W31882050 hasConcept C519581460 @default.
- W31882050 hasConcept C55493867 @default.
- W31882050 hasConcept C56173144 @default.
- W31882050 hasConcept C71924100 @default.
- W31882050 hasConcept C98274493 @default.
- W31882050 hasConceptScore W31882050C126322002 @default.
- W31882050 hasConceptScore W31882050C170493617 @default.
- W31882050 hasConceptScore W31882050C178790620 @default.
- W31882050 hasConceptScore W31882050C185592680 @default.
- W31882050 hasConceptScore W31882050C2775915353 @default.
- W31882050 hasConceptScore W31882050C2776885963 @default.
- W31882050 hasConceptScore W31882050C2778198053 @default.
- W31882050 hasConceptScore W31882050C2778938600 @default.
- W31882050 hasConceptScore W31882050C2779281246 @default.
- W31882050 hasConceptScore W31882050C2779395532 @default.
- W31882050 hasConceptScore W31882050C2780189551 @default.
- W31882050 hasConceptScore W31882050C2992686903 @default.
- W31882050 hasConceptScore W31882050C519581460 @default.
- W31882050 hasConceptScore W31882050C55493867 @default.
- W31882050 hasConceptScore W31882050C56173144 @default.
- W31882050 hasConceptScore W31882050C71924100 @default.
- W31882050 hasConceptScore W31882050C98274493 @default.
- W31882050 hasFunder F4320325580 @default.
- W31882050 hasIssue "S1" @default.
- W31882050 hasLocation W318820501 @default.
- W31882050 hasOpenAccess W31882050 @default.
- W31882050 hasPrimaryLocation W318820501 @default.
- W31882050 hasRelatedWork W1531480982 @default.
- W31882050 hasRelatedWork W1984551968 @default.
- W31882050 hasRelatedWork W2002936354 @default.
- W31882050 hasRelatedWork W2042904529 @default.
- W31882050 hasRelatedWork W2048159221 @default.
- W31882050 hasRelatedWork W2054842139 @default.
- W31882050 hasRelatedWork W2077066996 @default.
- W31882050 hasRelatedWork W2157721575 @default.
- W31882050 hasRelatedWork W2725292665 @default.
- W31882050 hasRelatedWork W2949732004 @default.
- W31882050 hasVolume "23" @default.
- W31882050 isParatext "false" @default.
- W31882050 isRetracted "false" @default.
- W31882050 magId "31882050" @default.
- W31882050 workType "article" @default.