Matches in SemOpenAlex for { <https://semopenalex.org/work/W3188291330> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3188291330 endingPage "143" @default.
- W3188291330 startingPage "135" @default.
- W3188291330 abstract "Introduction: Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which began in late 2019 in Wuhan, China, has become a global epidemic. Angiotensin 2 converting enzyme (ACE2) acts as a receptor for host function to cause acute coronavirus 2 acute respiratory syndrome (SARS-CoV-2). ACE2 is abundantly expressed in different cells of different human organs. In human physiology, ACE2 is a major player in the renin-angiotensin-aldosterone (RAAS) system by degrading angiotensin II. Many factors have been associated with altered ACE2 expression and the severity and progression of COVID-19, including microRNAs that may be effective in it. Identifying pathological changes due to SARS-CoV-2 infection is important because it has major implications for understanding the pathophysiology of COVID-19 and developing evidence-based treatment strategies. Currently, many intervention strategies are being explored in ongoing clinical trials. Objective: The aim of this study is to use bioinformatics databases to find potential antiviral therapies against SARS-CoV-2 through host microRNAs (miRNAs) that can reduce viral gene expression to inhibit virus entry and replication. Methods: Using different algorithms in TargetScan, DIANA, ENCORI and miRWalk databases, the potential microRNAs were identified that target ACE2. Then, a score table was prepared from the candidate microRNAs, based on the affinity of the seed region of microRNAs and the 3`-UTR region of the ACE2 gene. Finally, microRNAs with higher scores were chosen as candidates for practical analysis. Results: The results of Bioinformatical analysis showed that Has-miR-200c-3p, Has-miR-29a, Has-miR-29c, and Has-miR-942 are most likely to inhibit ACE2. These microRNAs are the most potent factors that might be affected on ACE2 during virulence. Conclusion: It seems that ACE2 is under the control of the miR-200c-3p and plays a crucial role in the pathophysiology process. Therefore, this microRNA can be considered as a suitable new candidate for experimental evaluation." @default.
- W3188291330 created "2021-08-16" @default.
- W3188291330 creator A5002338627 @default.
- W3188291330 creator A5017947632 @default.
- W3188291330 creator A5059140056 @default.
- W3188291330 creator A5083798732 @default.
- W3188291330 creator A5085211412 @default.
- W3188291330 date "2021-12-30" @default.
- W3188291330 modified "2023-09-26" @default.
- W3188291330 title "Bioinformatic Evaluation of the miRNAs Targeting ACE2 Gene in COVID-19" @default.
- W3188291330 doi "https://doi.org/10.34172/ddj.2021.26" @default.
- W3188291330 hasPublicationYear "2021" @default.
- W3188291330 type Work @default.
- W3188291330 sameAs 3188291330 @default.
- W3188291330 citedByCount "1" @default.
- W3188291330 countsByYear W31882913302023 @default.
- W3188291330 crossrefType "journal-article" @default.
- W3188291330 hasAuthorship W3188291330A5002338627 @default.
- W3188291330 hasAuthorship W3188291330A5017947632 @default.
- W3188291330 hasAuthorship W3188291330A5059140056 @default.
- W3188291330 hasAuthorship W3188291330A5083798732 @default.
- W3188291330 hasAuthorship W3188291330A5085211412 @default.
- W3188291330 hasBestOaLocation W31882913301 @default.
- W3188291330 hasConcept C104317684 @default.
- W3188291330 hasConcept C126322002 @default.
- W3188291330 hasConcept C134018914 @default.
- W3188291330 hasConcept C145059251 @default.
- W3188291330 hasConcept C159047783 @default.
- W3188291330 hasConcept C198710026 @default.
- W3188291330 hasConcept C2522874641 @default.
- W3188291330 hasConcept C2775946041 @default.
- W3188291330 hasConcept C2777648638 @default.
- W3188291330 hasConcept C2779134260 @default.
- W3188291330 hasConcept C3008058167 @default.
- W3188291330 hasConcept C524204448 @default.
- W3188291330 hasConcept C54355233 @default.
- W3188291330 hasConcept C60644358 @default.
- W3188291330 hasConcept C70721500 @default.
- W3188291330 hasConcept C71924100 @default.
- W3188291330 hasConcept C84393581 @default.
- W3188291330 hasConcept C86803240 @default.
- W3188291330 hasConceptScore W3188291330C104317684 @default.
- W3188291330 hasConceptScore W3188291330C126322002 @default.
- W3188291330 hasConceptScore W3188291330C134018914 @default.
- W3188291330 hasConceptScore W3188291330C145059251 @default.
- W3188291330 hasConceptScore W3188291330C159047783 @default.
- W3188291330 hasConceptScore W3188291330C198710026 @default.
- W3188291330 hasConceptScore W3188291330C2522874641 @default.
- W3188291330 hasConceptScore W3188291330C2775946041 @default.
- W3188291330 hasConceptScore W3188291330C2777648638 @default.
- W3188291330 hasConceptScore W3188291330C2779134260 @default.
- W3188291330 hasConceptScore W3188291330C3008058167 @default.
- W3188291330 hasConceptScore W3188291330C524204448 @default.
- W3188291330 hasConceptScore W3188291330C54355233 @default.
- W3188291330 hasConceptScore W3188291330C60644358 @default.
- W3188291330 hasConceptScore W3188291330C70721500 @default.
- W3188291330 hasConceptScore W3188291330C71924100 @default.
- W3188291330 hasConceptScore W3188291330C84393581 @default.
- W3188291330 hasConceptScore W3188291330C86803240 @default.
- W3188291330 hasIssue "4" @default.
- W3188291330 hasLocation W31882913301 @default.
- W3188291330 hasLocation W31882913302 @default.
- W3188291330 hasOpenAccess W3188291330 @default.
- W3188291330 hasPrimaryLocation W31882913301 @default.
- W3188291330 hasRelatedWork W1982169919 @default.
- W3188291330 hasRelatedWork W2003416812 @default.
- W3188291330 hasRelatedWork W2118836977 @default.
- W3188291330 hasRelatedWork W2150472220 @default.
- W3188291330 hasRelatedWork W260408919 @default.
- W3188291330 hasRelatedWork W2888659845 @default.
- W3188291330 hasRelatedWork W3013171238 @default.
- W3188291330 hasRelatedWork W3037833447 @default.
- W3188291330 hasRelatedWork W3029614368 @default.
- W3188291330 hasRelatedWork W3045672972 @default.
- W3188291330 hasVolume "10" @default.
- W3188291330 isParatext "false" @default.
- W3188291330 isRetracted "false" @default.
- W3188291330 magId "3188291330" @default.
- W3188291330 workType "article" @default.