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- W3188346029 abstract "Abstract This study investigated the effects of intrauterine growth restriction during late pregnancy on the ovine fetal renal function and renal antioxidant capacity. Eighteen ewes pregnant were randomly divided into control group (CG, ad libitum, 0.67 MJ ME·BW −0.75 ·day −1 , n = 6), restricted group 1 (RG1, 0.18 MJ ME·BW −0.75 ·day −1 , n = 6), and restricted group 2 (RG2, 0.33 MJ ME·BW −0.75 ·day −1 , n = 6). At 140 days, the fetal blood, allantoic fluid and kidney tissue were collected to determinate fetal renal function and renal antioxidant capacity. The results showed that the fetal weight, kidney weight, superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), aquaporin‐2 (AQP‐2) and aquaporin‐3 (AQP‐3), and total antioxidant capacity (T‐AOC) in RG1 group were decreased compared with the CG ( P < 0.05), but the contents of β2‐Microglobulin (β 2‐MG), cystatin C (Cys‐C), filtered sodium excretion fraction (FENa), malondialdehyde (MDA), and hydroxyl radical (OH) in RG1 group were increased ( P < 0.05). The impaired ovine fetal renal growth, antioxidant imbalance and dysfunction of glomerulus ultrafiltration, and the renal tubules reabsorption were induced by maternal malnutrition during late pregnancy." @default.
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- W3188346029 date "2021-01-01" @default.
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- W3188346029 title "Effects of intrauterine growth restriction during late pregnancy on the ovine fetal renal function and antioxidant capacity" @default.
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- W3188346029 doi "https://doi.org/10.1111/asj.13613" @default.
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