Matches in SemOpenAlex for { <https://semopenalex.org/work/W3188401490> ?p ?o ?g. }
- W3188401490 endingPage "806" @default.
- W3188401490 startingPage "806" @default.
- W3188401490 abstract "Gestational diabetes mellitus (GDM) is carbohydrate intolerance that occurs during pregnancy. This disease may lead to various maternal and neonatal complications; therefore, early diagnosis is very important. Because of the similarity in pathogenesis of type 2 diabetes and GDM, the genetic variants associated with type 2 diabetes are commonly investigated in GDM. The aim of the present study was to examine the associations between the polymorphisms in the ADCY5 (rs11708067, rs2877716), CAPN10 (rs2975760, rs3792267), and JAZF1 (rs864745) genes and GDM as well as to determine the expression of these genes in the placenta. This study included 272 pregnant women with GDM and 348 pregnant women with normal glucose tolerance. The diagnosis of GDM was based on a 75 g oral glucose tolerance test (OGTT) at 24–28 weeks gestation, according to International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. There were no statistically significant differences in the distribution of the ADCY5 gene (rs11708067, rs2877716) and CAPN10 gene (rs2975760, rs3792267) polymorphisms between pregnant women with normal carbohydrate tolerance and pregnant women with GDM. We have shown a lower frequency of JAZF1 gene rs864745 C allele carriers among women with GDM CC + CT vs. TT (OR = 0.60, 95% CI = 0.41–0.87, p = 0.006), and C vs. T (OR = 0.75, 95% CI = 0.60–0.95, p = 0.014). In addition, ADCY5 and JAZF1 gene expression was statistically significantly increased in the placentas of women with GDM compared with that of healthy women. The expression of the CAPN10 gene did not differ significantly between women with and without GDM. Our results indicate increased expression of JAZF1 and ADCY5 genes in the placentas of women with GDM as well as a protective effect of the C allele of the JAZF1 rs864745 gene polymorphism on the development of GDM in pregnant women." @default.
- W3188401490 created "2021-08-16" @default.
- W3188401490 creator A5021279291 @default.
- W3188401490 creator A5026979519 @default.
- W3188401490 creator A5037181676 @default.
- W3188401490 creator A5042118147 @default.
- W3188401490 creator A5047321589 @default.
- W3188401490 creator A5052605526 @default.
- W3188401490 creator A5064003338 @default.
- W3188401490 creator A5091589940 @default.
- W3188401490 date "2021-08-09" @default.
- W3188401490 modified "2023-09-25" @default.
- W3188401490 title "ADCY5, CAPN10 and JAZF1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes" @default.
- W3188401490 cites W1972342739 @default.
- W3188401490 cites W1975533854 @default.
- W3188401490 cites W1977624220 @default.
- W3188401490 cites W1984645442 @default.
- W3188401490 cites W1990137246 @default.
- W3188401490 cites W1996029701 @default.
- W3188401490 cites W2011427512 @default.
- W3188401490 cites W2013317847 @default.
- W3188401490 cites W2030725376 @default.
- W3188401490 cites W2050855592 @default.
- W3188401490 cites W2051908899 @default.
- W3188401490 cites W2054912471 @default.
- W3188401490 cites W2079577144 @default.
- W3188401490 cites W2097605596 @default.
- W3188401490 cites W2097748551 @default.
- W3188401490 cites W2113978399 @default.
- W3188401490 cites W2120041117 @default.
- W3188401490 cites W2125096632 @default.
- W3188401490 cites W2126785682 @default.
- W3188401490 cites W2135349969 @default.
- W3188401490 cites W2135902632 @default.
- W3188401490 cites W2140897490 @default.
- W3188401490 cites W2141412000 @default.
- W3188401490 cites W2147153092 @default.
- W3188401490 cites W2157772347 @default.
- W3188401490 cites W2161381121 @default.
- W3188401490 cites W2186803051 @default.
- W3188401490 cites W2588309716 @default.
- W3188401490 cites W2621862871 @default.
- W3188401490 cites W2734033274 @default.
- W3188401490 cites W2790951189 @default.
- W3188401490 cites W2803459701 @default.
- W3188401490 cites W2886448859 @default.
- W3188401490 cites W2889508718 @default.
- W3188401490 cites W2961526883 @default.
- W3188401490 cites W3041574456 @default.
- W3188401490 cites W3156791526 @default.
- W3188401490 doi "https://doi.org/10.3390/life11080806" @default.
- W3188401490 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8399092" @default.
- W3188401490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34440550" @default.
- W3188401490 hasPublicationYear "2021" @default.
- W3188401490 type Work @default.
- W3188401490 sameAs 3188401490 @default.
- W3188401490 citedByCount "8" @default.
- W3188401490 countsByYear W31884014902022 @default.
- W3188401490 countsByYear W31884014902023 @default.
- W3188401490 crossrefType "journal-article" @default.
- W3188401490 hasAuthorship W3188401490A5021279291 @default.
- W3188401490 hasAuthorship W3188401490A5026979519 @default.
- W3188401490 hasAuthorship W3188401490A5037181676 @default.
- W3188401490 hasAuthorship W3188401490A5042118147 @default.
- W3188401490 hasAuthorship W3188401490A5047321589 @default.
- W3188401490 hasAuthorship W3188401490A5052605526 @default.
- W3188401490 hasAuthorship W3188401490A5064003338 @default.
- W3188401490 hasAuthorship W3188401490A5091589940 @default.
- W3188401490 hasBestOaLocation W31884014901 @default.
- W3188401490 hasConcept C104317684 @default.
- W3188401490 hasConcept C126322002 @default.
- W3188401490 hasConcept C131872663 @default.
- W3188401490 hasConcept C134018914 @default.
- W3188401490 hasConcept C172680121 @default.
- W3188401490 hasConcept C180754005 @default.
- W3188401490 hasConcept C2776953305 @default.
- W3188401490 hasConcept C2777180221 @default.
- W3188401490 hasConcept C2779234561 @default.
- W3188401490 hasConcept C2779434492 @default.
- W3188401490 hasConcept C2780942790 @default.
- W3188401490 hasConcept C29456083 @default.
- W3188401490 hasConcept C46973012 @default.
- W3188401490 hasConcept C54355233 @default.
- W3188401490 hasConcept C555293320 @default.
- W3188401490 hasConcept C71924100 @default.
- W3188401490 hasConcept C86803240 @default.
- W3188401490 hasConceptScore W3188401490C104317684 @default.
- W3188401490 hasConceptScore W3188401490C126322002 @default.
- W3188401490 hasConceptScore W3188401490C131872663 @default.
- W3188401490 hasConceptScore W3188401490C134018914 @default.
- W3188401490 hasConceptScore W3188401490C172680121 @default.
- W3188401490 hasConceptScore W3188401490C180754005 @default.
- W3188401490 hasConceptScore W3188401490C2776953305 @default.
- W3188401490 hasConceptScore W3188401490C2777180221 @default.
- W3188401490 hasConceptScore W3188401490C2779234561 @default.
- W3188401490 hasConceptScore W3188401490C2779434492 @default.
- W3188401490 hasConceptScore W3188401490C2780942790 @default.
- W3188401490 hasConceptScore W3188401490C29456083 @default.