FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3188405770> ?p ?o ?g. }

• W3188405770 abstract "Modern biomedical science still experiences a significant need for easy and reliable sources of human cells. They are used to investigate pathological processes underlying disease, conduct pharmacological studies, and eventually applied as a therapeutic product in regenerative medicine. For decades, the pool of adult mesenchymal stem/stromal cells (MSCs) remains a promising source of stem and progenitor cells. Their isolation is more feasible than most other stem cells from human donors, yet they have a fair share of drawbacks. They include significant variability between donors, loss of potency, and transformation during long-term culture, which may impact the efficacy and reproducibility of research. One possible solution is a derivation of immortalized MSCs lines which receive a broader use in many medical and biological studies. In the present work, we demonstrated that in the most widely spread commercially available hTERT-immortalized MSCs cell line ASC52telo, sensitivity to hormonal stimuli was reduced, affecting their differentiation efficacy. Furthermore, we found that immortalized MSCs have impaired insulin-dependent and cAMP-dependent signaling, which impairs their adipogenic, but not osteogenic or chondrogenic, potential under experimental conditions. Our findings indicate that hTERT-immortalized MSCs may present a suboptimal choice for studies involving modeling or investigation of hormonal sensitivity." @default.
• W3188405770 created "2021-08-16" @default.
• W3188405770 creator A5004742893 @default.
• W3188405770 creator A5026663246 @default.
• W3188405770 creator A5028843398 @default.
• W3188405770 creator A5031206015 @default.
• W3188405770 creator A5034675608 @default.
• W3188405770 creator A5035482823 @default.
• W3188405770 creator A5058056357 @default.
• W3188405770 creator A5070227488 @default.
• W3188405770 creator A5078387383 @default.
• W3188405770 creator A5081130308 @default.
• W3188405770 creator A5083757966 @default.
• W3188405770 date "2021-08-04" @default.
• W3188405770 modified "2023-10-15" @default.
• W3188405770 title "Decreased Insulin Sensitivity in Telomerase-Immortalized Mesenchymal Stem Cells Affects Efficacy and Outcome of Adipogenic Differentiation in vitro" @default.
• W3188405770 cites W1594860261 @default.
• W3188405770 cites W1927710737 @default.
• W3188405770 cites W1965863460 @default.
• W3188405770 cites W1977241157 @default.
• W3188405770 cites W1992283898 @default.
• W3188405770 cites W1998776130 @default.
• W3188405770 cites W2016701686 @default.
• W3188405770 cites W2018258390 @default.
• W3188405770 cites W2020865621 @default.
• W3188405770 cites W2025371271 @default.
• W3188405770 cites W2029931902 @default.
• W3188405770 cites W2045475041 @default.
• W3188405770 cites W2061410279 @default.
• W3188405770 cites W2090947054 @default.
• W3188405770 cites W2108482850 @default.
• W3188405770 cites W2110973683 @default.
• W3188405770 cites W2137563421 @default.
• W3188405770 cites W2142456569 @default.
• W3188405770 cites W2171308531 @default.
• W3188405770 cites W2234163498 @default.
• W3188405770 cites W2581166051 @default.
• W3188405770 cites W2614669617 @default.
• W3188405770 cites W2766248868 @default.
• W3188405770 cites W2767335281 @default.
• W3188405770 cites W2768307668 @default.
• W3188405770 cites W2768790875 @default.
• W3188405770 cites W2775315035 @default.
• W3188405770 cites W2809112830 @default.
• W3188405770 cites W2809355409 @default.
• W3188405770 cites W2895445435 @default.
• W3188405770 cites W2898376503 @default.
• W3188405770 cites W2900485409 @default.
• W3188405770 cites W2900924619 @default.
• W3188405770 cites W2924170852 @default.
• W3188405770 cites W2991416247 @default.
• W3188405770 cites W2994801637 @default.
• W3188405770 cites W3003694094 @default.
• W3188405770 cites W3004936872 @default.
• W3188405770 cites W3035832355 @default.
• W3188405770 cites W3089175271 @default.
• W3188405770 doi "https://doi.org/10.3389/fcell.2021.662078" @default.
• W3188405770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8371914" @default.
• W3188405770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34422797" @default.
• W3188405770 hasPublicationYear "2021" @default.
• W3188405770 type Work @default.
• W3188405770 sameAs 3188405770 @default.
• W3188405770 citedByCount "6" @default.
• W3188405770 countsByYear W31884057702022 @default.
• W3188405770 countsByYear W31884057702023 @default.
• W3188405770 crossrefType "journal-article" @default.
• W3188405770 hasAuthorship W3188405770A5004742893 @default.
• W3188405770 hasAuthorship W3188405770A5026663246 @default.
• W3188405770 hasAuthorship W3188405770A5028843398 @default.
• W3188405770 hasAuthorship W3188405770A5031206015 @default.
• W3188405770 hasAuthorship W3188405770A5034675608 @default.
• W3188405770 hasAuthorship W3188405770A5035482823 @default.
• W3188405770 hasAuthorship W3188405770A5058056357 @default.
• W3188405770 hasAuthorship W3188405770A5070227488 @default.
• W3188405770 hasAuthorship W3188405770A5078387383 @default.
• W3188405770 hasAuthorship W3188405770A5081130308 @default.
• W3188405770 hasAuthorship W3188405770A5083757966 @default.
• W3188405770 hasBestOaLocation W31884057701 @default.
• W3188405770 hasConcept C104317684 @default.
• W3188405770 hasConcept C10854531 @default.
• W3188405770 hasConcept C122927707 @default.
• W3188405770 hasConcept C123012128 @default.
• W3188405770 hasConcept C143441281 @default.
• W3188405770 hasConcept C198826908 @default.
• W3188405770 hasConcept C201750760 @default.
• W3188405770 hasConcept C202751555 @default.
• W3188405770 hasConcept C203014093 @default.
• W3188405770 hasConcept C20875687 @default.
• W3188405770 hasConcept C28328180 @default.
• W3188405770 hasConcept C502942594 @default.
• W3188405770 hasConcept C54355233 @default.
• W3188405770 hasConcept C55493867 @default.
• W3188405770 hasConcept C6045943 @default.
• W3188405770 hasConcept C81885089 @default.
• W3188405770 hasConcept C86803240 @default.
• W3188405770 hasConcept C94581717 @default.
• W3188405770 hasConcept C95444343 @default.
• W3188405770 hasConceptScore W3188405770C104317684 @default.
• W3188405770 hasConceptScore W3188405770C10854531 @default.
• W3188405770 hasConceptScore W3188405770C122927707 @default.

• next