Matches in SemOpenAlex for { <https://semopenalex.org/work/W3188421036> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3188421036 abstract "Abstract Background Invasive fungal disease (IFD) is a severe complication after haploidentical stem cell transplantation (haplo-HSCT) and has a poor prognosis. It has been shown that genetic polymorphism may be one possible reason for the increased risk of IFD. This study aimed to assess the role of genetic polymorphisms in the level of susceptibility to IFD in after haplo-HSCT. Methods In this study, we prospectively enrolled 251 patients who received haplo-HSCT at the Peking University Institute of Hematology from to 2016-2018. Forty-three single nucleotide polymorphisms (SNPs) of the genomic DNA were genotyped in blood samples from both recipient and donor. Results Twenty-two patients (8.8%) were diagnosed with proven or probable IFD. The independent risk factors for IFD were grades 3-4 acute graft-versus-host disease, cytomegalovirus reactivation, and recipient and donor rs2305619 (PTX3) (P<0.05) in multivariate analysis. Meanwhile, we combined the variables to develop the IFD risk scoring system and stratified patients into low- (0), intermediate- (1-2), and high-risk (3-4) groups. The 30-day and 100-day cumulative incidence of IFD in the low-, intermediate-, and high-risk groups were 0.1%, 2.4%, 10.2% and 4.5%, 4.1%, 20.3%, respectively (P=0.015). Conclusions PTX3 rs2305619 polymorphisms increase the susceptibility of IFD after haplo-HSCT in the Chinese Han population, and the IFD scoring system could be considered as a new standard for risk stratification for IFD after HSCT." @default.
- W3188421036 created "2021-08-16" @default.
- W3188421036 creator A5012829362 @default.
- W3188421036 creator A5037029781 @default.
- W3188421036 creator A5047641392 @default.
- W3188421036 creator A5061407928 @default.
- W3188421036 creator A5065894155 @default.
- W3188421036 creator A5067057238 @default.
- W3188421036 date "2021-08-12" @default.
- W3188421036 modified "2023-10-01" @default.
- W3188421036 title "Recipient And Donor PTX3 rs2305619 Polymorphisms Increase The Susceptibility To Invasive Fungal Disease Following Haploidentical Stem Cell Transplantation: A Prospective Study" @default.
- W3188421036 doi "https://doi.org/10.21203/rs.3.rs-770441/v1" @default.
- W3188421036 hasPublicationYear "2021" @default.
- W3188421036 type Work @default.
- W3188421036 sameAs 3188421036 @default.
- W3188421036 citedByCount "0" @default.
- W3188421036 crossrefType "posted-content" @default.
- W3188421036 hasAuthorship W3188421036A5012829362 @default.
- W3188421036 hasAuthorship W3188421036A5037029781 @default.
- W3188421036 hasAuthorship W3188421036A5047641392 @default.
- W3188421036 hasAuthorship W3188421036A5061407928 @default.
- W3188421036 hasAuthorship W3188421036A5065894155 @default.
- W3188421036 hasAuthorship W3188421036A5067057238 @default.
- W3188421036 hasBestOaLocation W31884210361 @default.
- W3188421036 hasConcept C104317684 @default.
- W3188421036 hasConcept C126322002 @default.
- W3188421036 hasConcept C135763542 @default.
- W3188421036 hasConcept C143998085 @default.
- W3188421036 hasConcept C153209595 @default.
- W3188421036 hasConcept C194409129 @default.
- W3188421036 hasConcept C203014093 @default.
- W3188421036 hasConcept C2777408962 @default.
- W3188421036 hasConcept C2779134260 @default.
- W3188421036 hasConcept C2908647359 @default.
- W3188421036 hasConcept C2911091166 @default.
- W3188421036 hasConcept C54355233 @default.
- W3188421036 hasConcept C71924100 @default.
- W3188421036 hasConcept C86803240 @default.
- W3188421036 hasConcept C88879693 @default.
- W3188421036 hasConcept C90924648 @default.
- W3188421036 hasConcept C99454951 @default.
- W3188421036 hasConceptScore W3188421036C104317684 @default.
- W3188421036 hasConceptScore W3188421036C126322002 @default.
- W3188421036 hasConceptScore W3188421036C135763542 @default.
- W3188421036 hasConceptScore W3188421036C143998085 @default.
- W3188421036 hasConceptScore W3188421036C153209595 @default.
- W3188421036 hasConceptScore W3188421036C194409129 @default.
- W3188421036 hasConceptScore W3188421036C203014093 @default.
- W3188421036 hasConceptScore W3188421036C2777408962 @default.
- W3188421036 hasConceptScore W3188421036C2779134260 @default.
- W3188421036 hasConceptScore W3188421036C2908647359 @default.
- W3188421036 hasConceptScore W3188421036C2911091166 @default.
- W3188421036 hasConceptScore W3188421036C54355233 @default.
- W3188421036 hasConceptScore W3188421036C71924100 @default.
- W3188421036 hasConceptScore W3188421036C86803240 @default.
- W3188421036 hasConceptScore W3188421036C88879693 @default.
- W3188421036 hasConceptScore W3188421036C90924648 @default.
- W3188421036 hasConceptScore W3188421036C99454951 @default.
- W3188421036 hasLocation W31884210361 @default.
- W3188421036 hasLocation W31884210362 @default.
- W3188421036 hasOpenAccess W3188421036 @default.
- W3188421036 hasPrimaryLocation W31884210361 @default.
- W3188421036 hasRelatedWork W1473782864 @default.
- W3188421036 hasRelatedWork W2004368639 @default.
- W3188421036 hasRelatedWork W2056597408 @default.
- W3188421036 hasRelatedWork W2086149900 @default.
- W3188421036 hasRelatedWork W2161996216 @default.
- W3188421036 hasRelatedWork W2360260519 @default.
- W3188421036 hasRelatedWork W2614629048 @default.
- W3188421036 hasRelatedWork W3030270997 @default.
- W3188421036 hasRelatedWork W3119648492 @default.
- W3188421036 hasRelatedWork W4366990249 @default.
- W3188421036 isParatext "false" @default.
- W3188421036 isRetracted "false" @default.
- W3188421036 magId "3188421036" @default.
- W3188421036 workType "article" @default.