FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3188533310> ?p ?o ?g. }

• W3188533310 endingPage "12" @default.
• W3188533310 startingPage "1" @default.
• W3188533310 abstract "Tetrapeptides containing a Cys-Gly-Cys motif and a propensity to adopt a reverse-turn structure were synthesized to evaluate how O-, N-, H-, and aromatic π donor groups might contribute to mercury(II) complex formation. Tetrapeptides Xaa-Cys-Gly-Cys, where Xaa is glycine, glutamate, histidine, or tryptophan, were prepared and reacted with mercury(II) chloride. Their complexation with mercury(II) was studied by spectroscopic methods and computational modeling. UV-vis studies confirmed that mercury(II) binds to the cysteinyl thiolates as indicated by characteristic ligand-to-metal-charge-transfer transitions for bisthiolated S-Hg-S complexes, which correspond to 1 : 1 mercury-peptide complex formation. ESI-MS data also showed dominant 1 : 1 mercury-peptide adducts that are consistent with double deprotonations from the cysteinyl thiols to form thiolates. These complexes exhibited a strong positive circular dichroism band at 210 nm and a negative band at 193 nm, indicating that these peptides adopted a β-turn structure after binding mercury(II). Theoretical studies confirmed that optimized 1 : 1 mercury-peptide complexes adopt β-turns stabilized by intramolecular hydrogen bonds. These optimized structures also illustrate how specific N-terminal side-chain donor groups can assume intramolecular interactions and contribute to complex stability. Fluorescence quenching results provided supporting data that the indole donor group could interact with the coordinated mercury. The results from this study indicate that N-terminal side-chain residues containing carboxylate, imidazole, or indole groups can participate in stabilizing dithiolated mercury(II) complexes. These structural insights on peripheral mercury-peptide interactions provide additional understanding of the chemistry of mercury(II) with side-chain donor groups in peptides." @default.
• W3188533310 created "2021-08-16" @default.
• W3188533310 creator A5020381236 @default.
• W3188533310 creator A5067695561 @default.
• W3188533310 creator A5070569771 @default.
• W3188533310 creator A5077181718 @default.
• W3188533310 creator A5082581380 @default.
• W3188533310 date "2021-07-23" @default.
• W3188533310 modified "2023-09-27" @default.
• W3188533310 title "Spectroscopic and Theoretical Studies of Hg(II) Complexation with Some Dicysteinyl Tetrapeptides" @default.
• W3188533310 cites W105839754 @default.
• W3188533310 cites W1586022877 @default.
• W3188533310 cites W1761456248 @default.
• W3188533310 cites W1969651682 @default.
• W3188533310 cites W1976088937 @default.
• W3188533310 cites W1980516919 @default.
• W3188533310 cites W1986171863 @default.
• W3188533310 cites W1986814520 @default.
• W3188533310 cites W1991355939 @default.
• W3188533310 cites W1993383767 @default.
• W3188533310 cites W2004224330 @default.
• W3188533310 cites W2015723183 @default.
• W3188533310 cites W2015854884 @default.
• W3188533310 cites W2034006585 @default.
• W3188533310 cites W2041933909 @default.
• W3188533310 cites W2045692105 @default.
• W3188533310 cites W2049703280 @default.
• W3188533310 cites W2063796154 @default.
• W3188533310 cites W2070042523 @default.
• W3188533310 cites W2071123242 @default.
• W3188533310 cites W2071718881 @default.
• W3188533310 cites W2079604571 @default.
• W3188533310 cites W2098778934 @default.
• W3188533310 cites W2104056430 @default.
• W3188533310 cites W2120269759 @default.
• W3188533310 cites W2124523054 @default.
• W3188533310 cites W2142189153 @default.
• W3188533310 cites W2146298489 @default.
• W3188533310 cites W2170600614 @default.
• W3188533310 cites W2254637519 @default.
• W3188533310 cites W2270290876 @default.
• W3188533310 cites W2324054144 @default.
• W3188533310 cites W2328961664 @default.
• W3188533310 cites W2617414321 @default.
• W3188533310 cites W2785579100 @default.
• W3188533310 cites W2791740537 @default.
• W3188533310 cites W3007305307 @default.
• W3188533310 cites W3022538291 @default.
• W3188533310 cites W4210953470 @default.
• W3188533310 cites W4242786396 @default.
• W3188533310 cites W4250221563 @default.
• W3188533310 doi "https://doi.org/10.1155/2021/9911474" @default.
• W3188533310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8328728" @default.
• W3188533310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34349795" @default.
• W3188533310 hasPublicationYear "2021" @default.
• W3188533310 type Work @default.
• W3188533310 sameAs 3188533310 @default.
• W3188533310 citedByCount "0" @default.
• W3188533310 crossrefType "journal-article" @default.
• W3188533310 hasAuthorship W3188533310A5020381236 @default.
• W3188533310 hasAuthorship W3188533310A5067695561 @default.
• W3188533310 hasAuthorship W3188533310A5070569771 @default.
• W3188533310 hasAuthorship W3188533310A5077181718 @default.
• W3188533310 hasAuthorship W3188533310A5082581380 @default.
• W3188533310 hasBestOaLocation W31885333101 @default.
• W3188533310 hasConcept C112887158 @default.
• W3188533310 hasConcept C133571119 @default.
• W3188533310 hasConcept C178790620 @default.
• W3188533310 hasConcept C185592680 @default.
• W3188533310 hasConcept C192527728 @default.
• W3188533310 hasConcept C199360897 @default.
• W3188533310 hasConcept C204921945 @default.
• W3188533310 hasConcept C2776706248 @default.
• W3188533310 hasConcept C2777777548 @default.
• W3188533310 hasConcept C2778074193 @default.
• W3188533310 hasConcept C2778460671 @default.
• W3188533310 hasConcept C2779281246 @default.
• W3188533310 hasConcept C2780874372 @default.
• W3188533310 hasConcept C32909587 @default.
• W3188533310 hasConcept C41008148 @default.
• W3188533310 hasConcept C515207424 @default.
• W3188533310 hasConcept C521977710 @default.
• W3188533310 hasConcept C55493867 @default.
• W3188533310 hasConcept C71240020 @default.
• W3188533310 hasConcept C75079739 @default.
• W3188533310 hasConcept C8010536 @default.
• W3188533310 hasConceptScore W3188533310C112887158 @default.
• W3188533310 hasConceptScore W3188533310C133571119 @default.
• W3188533310 hasConceptScore W3188533310C178790620 @default.
• W3188533310 hasConceptScore W3188533310C185592680 @default.
• W3188533310 hasConceptScore W3188533310C192527728 @default.
• W3188533310 hasConceptScore W3188533310C199360897 @default.
• W3188533310 hasConceptScore W3188533310C204921945 @default.
• W3188533310 hasConceptScore W3188533310C2776706248 @default.
• W3188533310 hasConceptScore W3188533310C2777777548 @default.
• W3188533310 hasConceptScore W3188533310C2778074193 @default.
• W3188533310 hasConceptScore W3188533310C2778460671 @default.
• W3188533310 hasConceptScore W3188533310C2779281246 @default.

• next