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• W3188544069 abstract "Ultrasound (US)-triggered sonodynamic therapy (SDT) proves itself to be a formidable tool in the fight against cancer, due to its large spectrum of uses as a non-invasive therapeutic measure, while also demonstrating itself to be a certain improvement upon traditional SDT therapeutics. However, tumor hypoxia remains to be a major challenge for oxygen-dependent SDT. This study describes the development of an innovative, multi-use, catalyst-based and improved SDT targeting cancer, through the employment of a sonosensitizing curcumin (Cur) load embedded within a MnO 2 core, together with an extraneous tumor cell membrane component. The latter allows for efficient tumor recognition properties. Hollowed-out MnO 2 allows for efficient drug delivery, together with catalyzing oxygen generation from hydrogen peroxide present in tumor tissue, leading to enhanced SDT efficacy through the induction of a reduced hypoxic state within the tumor. In addition, Cur acts as a cytotoxic agent in its own right. The results deriving from in vivo studies revealed that such a biomimetic approach for drug-delivery actually led to a reduced hypoxic state within tumor tissue and a raised tumor-inhibitory effect within mouse models. Such a therapeutic measure attained a synergic SDT-based tumor sensitization treatment option, together with the potential use of such catalysis-based therapeutic formulations in other medical conditions having hypoxic states." @default.
• W3188544069 created "2021-08-16" @default.
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• W3188544069 date "2021-07-30" @default.
• W3188544069 modified "2023-10-15" @default.
• W3188544069 title "A Novel Bionic Catalyst-Mediated Drug Delivery System for Enhanced Sonodynamic Therapy" @default.
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• W3188544069 doi "https://doi.org/10.3389/fbioe.2021.699737" @default.
• W3188544069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8361452" @default.
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