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• W3188620146 abstract "Non-typeable Haemophilus influenzae (NTHi) is an ubiquitous commensal-turned-pathogen that colonises the respiratory mucosa in airways diseases including Chronic Obstructive Pulmonary Disease (COPD). COPD is a progressive inflammatory syndrome of the lungs, encompassing chronic bronchitis that is characterised by mucus hypersecretion and impaired mucociliary clearance and creates a static, protective, humid, and nutrient-rich environment, with dysregulated mucosal immunity; a favourable environment for NTHi colonisation. Several recent large COPD cohort studies have reported NTHi as a significant and recurrent aetiological pathogen in acute exacerbations of COPD. NTHi proliferation has been associated with increased hospitalisation, disease severity, morbidity and significant lung microbiome shifts. However, some cohorts with patients at different severities of COPD do not report that NTHi is a significant aetiological pathogen in their COPD patients, indicating other obligate pathogens including Moraxella catarrhalis, Streptococcus pneumoniae and Pseudomonas aeruginosa as the cause. NTHi is an ubiquitous organism across healthy non-smokers, healthy smokers and COPD patients from childhood to adulthood, but it currently remains unclear why NTHi becomes pathogenic in only some cohorts of COPD patients, and what behaviours, interactions and adaptations are driving this susceptibility. There is emerging evidence that biofilm-phase NTHi may play a significant role in COPD. NTHi displays many hallmarks of the biofilm lifestyle and expresses key biofilm formation-promoting genes. These include the autoinducer-mediated quorum sensing system, epithelial- and mucus-binding adhesins and expression of a protective, self-produced polymeric substance matrix. These NTHi biofilms exhibit extreme tolerance to antimicrobial treatments and the immune system as well as expressing synergistic interspecific interactions with other lung pathogens including S. pneumoniae and M. catarrhalis . Whilst the majority of our understanding surrounding NTHi as a biofilm arises from otitis media or in-vitro bacterial monoculture models, the role of NTHi biofilms in the COPD lung is now being studied. This review explores the evidence for the existence of NTHi biofilms and their impact in the COPD lung. Understanding the nature of chronic and recurrent NTHi infections in acute exacerbations of COPD could have important implications for clinical treatment and identification of novel bactericidal targets." @default.
• W3188620146 created "2021-08-16" @default.
• W3188620146 creator A5010011502 @default.
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• W3188620146 creator A5069988933 @default.
• W3188620146 date "2021-08-04" @default.
• W3188620146 modified "2023-10-13" @default.
• W3188620146 title "The Role of Non-Typeable Haemophilus influenzae Biofilms in Chronic Obstructive Pulmonary Disease" @default.
• W3188620146 cites W1555256864 @default.
• W3188620146 cites W1749998966 @default.
• W3188620146 cites W1868267074 @default.
• W3188620146 cites W1963599293 @default.
• W3188620146 cites W1965968949 @default.
• W3188620146 cites W1966931970 @default.
• W3188620146 cites W1972022879 @default.
• W3188620146 cites W1974939755 @default.
• W3188620146 cites W1977214698 @default.
• W3188620146 cites W1977826038 @default.
• W3188620146 cites W1989405523 @default.
• W3188620146 cites W1989993690 @default.
• W3188620146 cites W1990806007 @default.
• W3188620146 cites W1995864757 @default.
• W3188620146 cites W1998601670 @default.
• W3188620146 cites W2008436254 @default.
• W3188620146 cites W201767693 @default.
• W3188620146 cites W2023379203 @default.
• W3188620146 cites W2025391152 @default.
• W3188620146 cites W2029362096 @default.
• W3188620146 cites W2036373771 @default.
• W3188620146 cites W2040835963 @default.
• W3188620146 cites W2050591900 @default.
• W3188620146 cites W2068332307 @default.
• W3188620146 cites W2068420419 @default.
• W3188620146 cites W2073344185 @default.
• W3188620146 cites W2079177004 @default.
• W3188620146 cites W2083598245 @default.
• W3188620146 cites W2084978587 @default.
• W3188620146 cites W2084978938 @default.
• W3188620146 cites W2088107697 @default.
• W3188620146 cites W2090154423 @default.
• W3188620146 cites W2100427599 @default.
• W3188620146 cites W2101600300 @default.
• W3188620146 cites W2104715871 @default.
• W3188620146 cites W2107106339 @default.
• W3188620146 cites W2111811046 @default.
• W3188620146 cites W2112796873 @default.
• W3188620146 cites W2113327952 @default.
• W3188620146 cites W2116345416 @default.
• W3188620146 cites W2117238486 @default.
• W3188620146 cites W2118216979 @default.
• W3188620146 cites W2122496280 @default.
• W3188620146 cites W2130723556 @default.
• W3188620146 cites W2132453764 @default.
• W3188620146 cites W2133070939 @default.
• W3188620146 cites W2133371096 @default.
• W3188620146 cites W2139060159 @default.
• W3188620146 cites W2142537027 @default.
• W3188620146 cites W2142791491 @default.
• W3188620146 cites W2149294227 @default.
• W3188620146 cites W2155979125 @default.
• W3188620146 cites W2156802581 @default.
• W3188620146 cites W2158227249 @default.
• W3188620146 cites W2160685531 @default.
• W3188620146 cites W2163401084 @default.
• W3188620146 cites W2165829657 @default.
• W3188620146 cites W2172046332 @default.
• W3188620146 cites W2306587013 @default.
• W3188620146 cites W2333373066 @default.
• W3188620146 cites W2338854241 @default.
• W3188620146 cites W2345523549 @default.
• W3188620146 cites W2358067539 @default.
• W3188620146 cites W2499297028 @default.
• W3188620146 cites W2502520931 @default.
• W3188620146 cites W2509396803 @default.
• W3188620146 cites W2517999915 @default.
• W3188620146 cites W2520242867 @default.
• W3188620146 cites W2546936385 @default.
• W3188620146 cites W2557842745 @default.
• W3188620146 cites W2559811406 @default.
• W3188620146 cites W2561759844 @default.
• W3188620146 cites W2607096286 @default.
• W3188620146 cites W2607948310 @default.
• W3188620146 cites W2612126073 @default.
• W3188620146 cites W2613136430 @default.
• W3188620146 cites W2619343165 @default.
• W3188620146 cites W2622656003 @default.
• W3188620146 cites W2633054493 @default.
• W3188620146 cites W2736184554 @default.
• W3188620146 cites W2740975896 @default.
• W3188620146 cites W2763841590 @default.
• W3188620146 cites W2784301535 @default.
• W3188620146 cites W2785692071 @default.
• W3188620146 cites W2790637257 @default.
• W3188620146 cites W2793387763 @default.
• W3188620146 cites W2802105343 @default.
• W3188620146 cites W2811469461 @default.
• W3188620146 cites W2884763889 @default.
• W3188620146 cites W2891474281 @default.

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