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- W3188686710 endingPage "8306" @default.
- W3188686710 startingPage "8306" @default.
- W3188686710 abstract "Mitochondria are energetic and dynamic organelles with a crucial role in bioenergetics, metabolism, and signaling. Mitochondrial proteins, encoded by both nuclear and mitochondrial DNA, must be properly regulated to ensure proteostasis. Mitochondrial protein quality control (MPQC) serves as a critical surveillance system, employing different pathways and regulators as cellular guardians to ensure mitochondrial protein quality and quantity. In this review, we describe key pathways and players in MPQC, such as mitochondrial protein translocation-associated degradation, mitochondrial stress responses, chaperones, and proteases, and how they work together to safeguard mitochondrial health and integrity. Deregulated MPQC leads to proteotoxicity and dysfunctional mitochondria, which contributes to numerous human diseases, including cancer. We discuss how alterations in MPQC components are linked to tumorigenesis, whether they act as drivers, suppressors, or both. Finally, we summarize recent advances that seek to target these alterations for the development of anti-cancer drugs." @default.
- W3188686710 created "2021-08-16" @default.
- W3188686710 creator A5005126432 @default.
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- W3188686710 creator A5019059741 @default.
- W3188686710 creator A5068469239 @default.
- W3188686710 creator A5069425003 @default.
- W3188686710 date "2021-08-02" @default.
- W3188686710 modified "2023-10-13" @default.
- W3188686710 title "Failure to Guard: Mitochondrial Protein Quality Control in Cancer" @default.
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