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- W3188729168 abstract "• Two novel 1,5-benzodiazepin-2-one derivatives were synthesized and characterized. • Relatively good correlations were obtained between experimental and predicted data. • DFT calculations and Hirshfeld surface analysis were performed. • The two derivatives show remarkable antibacterial activity. • Both derivatives show favorable interactions into the active site of DNA gyrase. Two novel 1,5-benzodiazepin-2-one derivatives were prepared and characterized using different spectroscopic techniques and single crystal X-ray diffraction. The DFT-B3LYP study was also performed to investigate differences in the electric properties. The in vitro antibacterial activity of three 1,5-benzodiazepine heterocyclic compounds was investigated against Escherichia coli ATCC 4157, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 25923 and Streptococcus faecalis ATCC 29212 bacterial strains. The results obtained showed the remarkable activity of compound 3 against S. faecalis and of compound 5 against E. coli, S. Aureus and S. faecalis with MICs of 5 μg / mL compared to the standard reference. Molecular docking was performed to position compounds 3, 4 and 5 into the S. aureus and E. coli active site to rationalize the probable mode of action, binding affinity, and orientation of the molecules at the active site of receptor." @default.
- W3188729168 created "2021-08-16" @default.
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- W3188729168 date "2022-01-01" @default.
- W3188729168 modified "2023-10-14" @default.
- W3188729168 title "Synthesis, spectroscopic characterization, crystal structure, DFT, ESI-MS studies, molecular docking and in vitro antibacterial activity of 1,5-benzodiazepin-2-one derivatives" @default.
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- W3188729168 doi "https://doi.org/10.1016/j.molstruc.2021.131188" @default.
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