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- W3188732077 abstract "Basement membranes (BMs) are highly specialised extracellular matrix (ECM) structures that within the heart underlie endothelial cells (ECs) and surround cardiomyocytes and vascular smooth muscle cells. They generate a dynamic and structurally supportive environment throughout cardiac development and maturation by providing physical anchorage to the underlying interstitium, structural support to the tissue, and by influencing cell behaviour and signalling. While this provides a strong link between BM dysfunction and cardiac disease, the role of the BM in cardiac biology remains under-researched and our understanding regarding the mechanistic interplay between BM defects and their morphological and functional consequences remain important knowledge-gaps. In this review, we bring together emerging understanding of BM defects within the heart including in common cardiovascular pathologies such as contractile dysfunction and highlight some key questions that are now ready to be addressed." @default.
- W3188732077 created "2021-08-16" @default.
- W3188732077 creator A5054846899 @default.
- W3188732077 creator A5077197547 @default.
- W3188732077 creator A5081205758 @default.
- W3188732077 date "2021-08-01" @default.
- W3188732077 modified "2023-10-12" @default.
- W3188732077 title "The role of basement membranes in cardiac biology and disease" @default.
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