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- W3188792319 endingPage "3940" @default.
- W3188792319 startingPage "3940" @default.
- W3188792319 abstract "Scaffolding proteins can play important roles in cell signaling transduction. IQ motif-containing GTPase-activating protein 1 (IQGAP1) influences many cellular activities by scaffolding multiple key signaling pathways, including ones involved in carcinogenesis. Two decades of studies provide evidence that IQGAP1 plays an essential role in promoting cancer development. IQGAP1 is overexpressed in many types of cancer, and its overexpression in cancer is associated with lower survival of the cancer patient. Here, we provide a comprehensive review of the literature regarding the oncogenic roles of IQGAP1. We start by describing the major cancer-related signaling pathways scaffolded by IQGAP1 and their associated cellular activities. We then describe clinical and molecular evidence for the contribution of IQGAP1 in different types of cancers. In the end, we review recent evidence implicating IQGAP1 in tumor-related immune responses. Given the critical role of IQGAP1 in carcinoma development, anti-tumor therapies targeting IQGAP1 or its associated signaling pathways could be beneficial for patients with many types of cancer." @default.
- W3188792319 created "2021-08-16" @default.
- W3188792319 creator A5004980575 @default.
- W3188792319 creator A5015582793 @default.
- W3188792319 date "2021-08-04" @default.
- W3188792319 modified "2023-10-16" @default.
- W3188792319 title "Role of IQGAP1 in Carcinogenesis" @default.
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