FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3188792497> ?p ?o ?g. }

• W3188792497 endingPage "223" @default.
• W3188792497 startingPage "221" @default.
• W3188792497 abstract "To the Editor: Retronychia is an ingrowth of the nail plate into the proximal nail fold, characterized by proximal nail fold inflammation.1de Berker D.A. Richert B. Duhard E. Piraccini B.M. André J. Baran R. Retronychia: proximal ingrowing of the nail plate.J Am Acad Dermatol. 2008; 58: 978-983Abstract Full Text Full Text PDF PubMed Scopus (74) Google Scholar Diagnosis is generally established with clinical findings, but most physicians are unfamiliar with retronychia. Knowledge of this condition will minimize its misdiagnosis and delayed diagnosis. This study aimed to investigate the clinical features and treatment outcomes of retronychia at our centers. Patients with retronychia from 3 referral hospitals in South Korea were evaluated retrospectively between 2015 and 2020. The inclusion criteria were: (1) proximal nail plate ingrowth, (2) proximal nail fold inflammation, and (3) interruption of nail growth. When infection was suspected, a bacterial or mycological examination was performed. It was approved by the institutional review board. Detailed methods and supplemental data are available via Mendeley at https://data.mendeley.com/datasets/f4bf4nhkv2/1. Forty-four patients with retronychia met our inclusion criteria (Table I). The patients, predominantly women (79.5%), had an average age of 45.1 ± 18.9 years. Their comorbidities included cancers (20.5%), renal diseases (9.1%), hypertension (6.8%), diabetes (4.5%), and rheumatic diseases (4.5%). The mean disease duration was 22.2 ± 30.5 months. Retronychia was located in the toenails in 40 patients (90.9%) and in the fingernails in 4 patients (9.1%). All cases of toenail retronychia occurred in the great toenail. In cases of fingernail retronychia, multiple fingernails (range, 2-3) were affected after cast immobilization and a right brachial plexus injury. A precipitating event was found in 27 cases (61.4%), with the majority being due to trauma.Table IPatient demographics and disease characteristics (N = 44)CharacteristicValueAge (y, SD)45.1 ± 18.9Sex, n (%) Female35 (79.5) Male9 (20.5)Comorbidities, n (%) Cancer9 (20.5) Renal diseases4 (9.1) Hypertension3 (6.8) Diabetes2 (4.5) Rheumatic diseases∗Rheumatoid arthritis (n = 1) and fibromyalgia (n = 1).2 (4.5) Hepatitis B virus1 (2.3) Hypothyroidism1 (2.3) Varicose vein1 (2.3) Mental retardation1 (2.3) Brachial plexus injury1 (2.3)Disease duration (mo, SD)†Two patients with unknown onset dates were omitted from the calculation.22.2 ± 30.5Symptoms, n (%) Pain37 (84.1) None7 (15.6)Involved digits, n (%) Toenails40 (90.9)Great toenail only39 (88.6)Unilateral28 (63.6)Bilateral11 (25.0)Multiple toenails including great toenail1 (2.3) Fingernails4 (9.1)Thumbnail1 (2.3)Other fingernails (second to fifth)3 (6.8)Presence of a precipitating event, n (%)27 (61.4) Trauma7 (15.9) Climbing/Hiking/Walked too much5 (11.4) Chemotherapy4 (9.1) Tight shoes3 (6.8) Cast immobilization3 (6.8) Nail surgery‡Ingrowing nail surgery (n = 1; after chemical matricectomy) and nail avulsion (n = 1).2 (4.5) Paronychia2 (4.5) After nail polish1 (2.3)History of antifungal treatment9 (20.5)SD, Standard deviation.∗ Rheumatoid arthritis (n = 1) and fibromyalgia (n = 1).† Two patients with unknown onset dates were omitted from the calculation.‡ Ingrowing nail surgery (n = 1; after chemical matricectomy) and nail avulsion (n = 1). Open table in a new tab SD, Standard deviation. Retronychia can be classified into 2 stages according to its severity.2Litaiem N. Drissi H. Zeglaoui F. Khachemoune A. Retronychia of the toenails: a review with emphasis on pathogenesis, new diagnostic and management trends.Arch Dermatol Res. 2019; 311: 505-512Crossref PubMed Scopus (10) Google Scholar,3Gerard E. Prevezas C. Doutre M.S. Beylot-Barry M. Cogrel O. Risk factors, clinical variants and therapeutic outcome of retronychia: a retrospective study of 18 patients.Eur J Dermatol. 2016; 26: 377-381Crossref PubMed Scopus (22) Google Scholar Stage 1, characterized by xanthonychia with mild paronychia and interrupted nail growth, was found in 77.3%. Stage 2, associated with severe paronychia and proximal nail plate elevation, was detected in 22.7%. The common clinical features were onychomadesis, followed by xanthonychia, subungual hemorrhage, and malalignment. Although these clinical features were similar to those in previous studies,3Gerard E. Prevezas C. Doutre M.S. Beylot-Barry M. Cogrel O. Risk factors, clinical variants and therapeutic outcome of retronychia: a retrospective study of 18 patients.Eur J Dermatol. 2016; 26: 377-381Crossref PubMed Scopus (22) Google Scholar,4Laird M.E. Lo Sicco K.I. Rich P. Conservative treatment of retronychia: a retrospective study of 25 patients.Dermatol Surg. 2019; 45: 614-616Crossref PubMed Scopus (5) Google Scholar malalignment has not been reported. Concurrent onychomycosis or bacterial infection was present in 25.0% and 22.7% of cases, respectively. After nail avulsion or spontaneous shedding, there was an improvement in all cases. Recurrence after nail avulsion was rare but was found in 3 cases during an average follow-up period of 12.4 months (Table II). Twelve patients received conservative management, including antifungal and antibiotic treatment in cases of concurrent infection. Most had fingernail involvement or stage 1 retronychia. During the average period of 9.2 months, improvement was achieved in 70.0%, and treatment failure occurred in 30.0%.Table IIClinical features and treatment outcomes of retronychia (N = 44)Clinical featuresValueRetronychia stage, n (%) Stage 134 (77.3) Stage 210 (22.7)Accompanying nail deformities, n (%) Onychomadesis37 (84.1) Xanthonychia36 (81.8) Subungual hemorrhage12 (27.3) Malalignment10 (22.7) Shrimp nail8 (18.2) Subungual hyperkeratosis7 (15.9) Beau's lines7 (15.9) Onycholysis4 (9.1) Pyogenic granuloma3 (6.8) Green nail3 (6.8) Foul odor2 (4.5) Onychogryphosis1 (2.3)Concurrent onychomycosis, n (%)11 (25.0)Concurrent bacterial infection, n (%)10 (22.7)Treatment outcomesValue Nail avulsion or nail shedding, n (%)32 (72.7)Surgical avulsion28 (87.5)Spontaneous nail shedding4 (12.5)Outcome∗Two patients who were lost to follow-up after treatment were omitted from the calculation.Resolution27 (90.0)Recurrence3 (10.0)Mean follow-up period (months, SD)12.4 ± 13.0 Conservative management, n (%)12 (27.3)Topical steroid6 (50.0)Topical/oral antibiotic5 (41.7)Topical/oral antifungal3 (25.0)Outcome†Two patients who were lost to follow-up after treatment were omitted from the calculation.Resolution7 (70.0)Not improved3 (30.0)Mean follow-up period (months, SD)9.2 ± 9.8SD, Standard deviation.∗ Two patients who were lost to follow-up after treatment were omitted from the calculation.† Two patients who were lost to follow-up after treatment were omitted from the calculation. Open table in a new tab SD, Standard deviation. To the best of our knowledge, this was the largest multicenter retrospective study on retronychia in Asia.2Litaiem N. Drissi H. Zeglaoui F. Khachemoune A. Retronychia of the toenails: a review with emphasis on pathogenesis, new diagnostic and management trends.Arch Dermatol Res. 2019; 311: 505-512Crossref PubMed Scopus (10) Google Scholar,4Laird M.E. Lo Sicco K.I. Rich P. Conservative treatment of retronychia: a retrospective study of 25 patients.Dermatol Surg. 2019; 45: 614-616Crossref PubMed Scopus (5) Google Scholar,5Lencastre A. Iorizzo M. Caucanas M. et al.Topical steroids for the treatment of retronychia.J Eur Acad Dermatol Venereol. 2019; 33: e320-e322Crossref PubMed Scopus (12) Google Scholar Our study found that nail changes such as onychomadesis, xanthonychia, subungual hemorrhage, and malalignment are important clues for the clinical diagnosis of retronychia in patients with chronic proximal nail fold inflammation. Surgical avulsion is the most effective treatment for retronychia, while conservative management can be considered in mild retronychia, especially after cast application. The limitations of this study include the retrospective study design and the inclusion of only Asian patients. Further research with a prospective study design for treatment strategies is needed. None disclosed." @default.
• W3188792497 created "2021-08-16" @default.
• W3188792497 creator A5024082527 @default.
• W3188792497 creator A5026159722 @default.
• W3188792497 creator A5059742237 @default.
• W3188792497 creator A5064222934 @default.
• W3188792497 creator A5072092879 @default.
• W3188792497 creator A5085883290 @default.
• W3188792497 date "2022-07-01" @default.
• W3188792497 modified "2023-09-27" @default.
• W3188792497 title "Clinical features and treatment outcomes of retronychia: A multicenter retrospective analysis in Korea" @default.
• W3188792497 cites W2091512089 @default.
• W3188792497 cites W2440932872 @default.
• W3188792497 cites W2897764706 @default.
• W3188792497 cites W2931044399 @default.
• W3188792497 cites W2944315204 @default.
• W3188792497 doi "https://doi.org/10.1016/j.jaad.2021.07.053" @default.
• W3188792497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34358584" @default.
• W3188792497 hasPublicationYear "2022" @default.
• W3188792497 type Work @default.
• W3188792497 sameAs 3188792497 @default.
• W3188792497 citedByCount "1" @default.
• W3188792497 countsByYear W31887924972023 @default.
• W3188792497 crossrefType "journal-article" @default.
• W3188792497 hasAuthorship W3188792497A5024082527 @default.
• W3188792497 hasAuthorship W3188792497A5026159722 @default.
• W3188792497 hasAuthorship W3188792497A5059742237 @default.
• W3188792497 hasAuthorship W3188792497A5064222934 @default.
• W3188792497 hasAuthorship W3188792497A5072092879 @default.
• W3188792497 hasAuthorship W3188792497A5085883290 @default.
• W3188792497 hasBestOaLocation W31887924971 @default.
• W3188792497 hasConcept C126322002 @default.
• W3188792497 hasConcept C167135981 @default.
• W3188792497 hasConcept C168563851 @default.
• W3188792497 hasConcept C17744445 @default.
• W3188792497 hasConcept C199539241 @default.
• W3188792497 hasConcept C2779473830 @default.
• W3188792497 hasConcept C2992435398 @default.
• W3188792497 hasConcept C71924100 @default.
• W3188792497 hasConceptScore W3188792497C126322002 @default.
• W3188792497 hasConceptScore W3188792497C167135981 @default.
• W3188792497 hasConceptScore W3188792497C168563851 @default.
• W3188792497 hasConceptScore W3188792497C17744445 @default.
• W3188792497 hasConceptScore W3188792497C199539241 @default.
• W3188792497 hasConceptScore W3188792497C2779473830 @default.
• W3188792497 hasConceptScore W3188792497C2992435398 @default.
• W3188792497 hasConceptScore W3188792497C71924100 @default.
• W3188792497 hasIssue "1" @default.
• W3188792497 hasLocation W31887924971 @default.
• W3188792497 hasLocation W31887924972 @default.
• W3188792497 hasOpenAccess W3188792497 @default.
• W3188792497 hasPrimaryLocation W31887924971 @default.
• W3188792497 hasRelatedWork W2105151527 @default.
• W3188792497 hasRelatedWork W2324013405 @default.
• W3188792497 hasRelatedWork W2951130915 @default.
• W3188792497 hasRelatedWork W3009852707 @default.
• W3188792497 hasRelatedWork W3013145321 @default.
• W3188792497 hasRelatedWork W3208090289 @default.
• W3188792497 hasRelatedWork W3210359220 @default.
• W3188792497 hasRelatedWork W4214517713 @default.
• W3188792497 hasRelatedWork W4255376461 @default.
• W3188792497 hasRelatedWork W4322723577 @default.
• W3188792497 hasVolume "87" @default.
• W3188792497 isParatext "false" @default.
• W3188792497 isRetracted "false" @default.
• W3188792497 magId "3188792497" @default.
• W3188792497 workType "article" @default.