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- W3188805902 abstract "Intravenous infusion of Intralipid is an adjunct therapy in assisted reproduction treatment (ART) when immune-associated infertility is suspected. Here, we evaluated the effect of Intralipid infusion on regulatory T cells (Treg cells), effector T cells and plasma cytokines in peripheral blood of women undertaking IVF.This prospective, observational pilot study assessed Intralipid infusion in 14 women exhibiting recurrent implantation failure, a clinical sign of immune-associated infertility. Peripheral blood was collected immediately prior to and 7 days after intravenous administration of Intralipid. Plasma cytokines were measured by Luminex, and T-cell subsets were analysed by flow cytometry.A small increase in conventional CD8+ T cells occurred after Intralipid infusion, but no change was seen in CD4+ Treg cells, or naïve, memory or effector memory T cells. Proliferation marker Ki67, transcription factors Tbet and RORγt, and markers of suppressive capacity CTLA4 and HLA-DR were unchanged. Dimensionality-reduction analysis using the tSNE algorithm confirmed no phenotype shift within Treg cells or other T cells. Intralipid infusion increased plasma CCL2, CCL3, CXCL8, GM-CSF, G-CSF, IL-6, IL-21, TNF and VEGF.Intralipid infusion elicited elevated pro-inflammatory cytokines, and a minor increase in CD8+ T cells, but no change in pro-tolerogenic Treg cells. Notwithstanding the limitation of no placebo control, the results do not support Intralipid as a candidate intervention to attenuate the Treg cell response in women undergoing ART. Future placebo-controlled studies are needed to confirm the potential efficacy and clinical significance of Intralipid in attenuating cytokine induction and circulating CD8+ T cells." @default.
- W3188805902 created "2021-08-16" @default.
- W3188805902 creator A5029518183 @default.
- W3188805902 creator A5037011219 @default.
- W3188805902 creator A5057681031 @default.
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- W3188805902 creator A5078118457 @default.
- W3188805902 creator A5079344414 @default.
- W3188805902 creator A5091143598 @default.
- W3188805902 date "2021-01-01" @default.
- W3188805902 modified "2023-10-01" @default.
- W3188805902 title "Effect of Intralipid infusion on peripheral blood T cells and plasma cytokines in women undergoing assisted reproduction treatment" @default.
- W3188805902 cites W1510223233 @default.
- W3188805902 cites W1549284688 @default.
- W3188805902 cites W1563750499 @default.
- W3188805902 cites W1600214033 @default.
- W3188805902 cites W1607026158 @default.
- W3188805902 cites W1635103958 @default.
- W3188805902 cites W177958585 @default.
- W3188805902 cites W1847593726 @default.
- W3188805902 cites W1965034704 @default.
- W3188805902 cites W1966799784 @default.
- W3188805902 cites W1972385567 @default.
- W3188805902 cites W1975913827 @default.
- W3188805902 cites W1995272947 @default.
- W3188805902 cites W1999662509 @default.
- W3188805902 cites W2000598875 @default.
- W3188805902 cites W2002997424 @default.
- W3188805902 cites W2025313810 @default.
- W3188805902 cites W2025615218 @default.
- W3188805902 cites W2026238172 @default.
- W3188805902 cites W2032304205 @default.
- W3188805902 cites W2044509542 @default.
- W3188805902 cites W2052766728 @default.
- W3188805902 cites W2053021474 @default.
- W3188805902 cites W2053858672 @default.
- W3188805902 cites W2053982294 @default.
- W3188805902 cites W2059216586 @default.
- W3188805902 cites W2060220862 @default.
- W3188805902 cites W2061507328 @default.
- W3188805902 cites W2063591322 @default.
- W3188805902 cites W2067202337 @default.
- W3188805902 cites W2082792002 @default.
- W3188805902 cites W2087021943 @default.
- W3188805902 cites W2088201271 @default.
- W3188805902 cites W2090709295 @default.
- W3188805902 cites W2092361429 @default.
- W3188805902 cites W2098394317 @default.
- W3188805902 cites W2100301211 @default.
- W3188805902 cites W2118899616 @default.
- W3188805902 cites W2124221440 @default.
- W3188805902 cites W2129222792 @default.
- W3188805902 cites W2130126684 @default.
- W3188805902 cites W2132790091 @default.
- W3188805902 cites W2132979326 @default.
- W3188805902 cites W2137653739 @default.
- W3188805902 cites W2140469952 @default.
- W3188805902 cites W2141894278 @default.
- W3188805902 cites W2147449078 @default.
- W3188805902 cites W2148226248 @default.
- W3188805902 cites W2150133629 @default.
- W3188805902 cites W2151052176 @default.
- W3188805902 cites W2162646944 @default.
- W3188805902 cites W2168610646 @default.
- W3188805902 cites W2172287196 @default.
- W3188805902 cites W2223972615 @default.
- W3188805902 cites W2230612506 @default.
- W3188805902 cites W2298645054 @default.
- W3188805902 cites W2344257391 @default.
- W3188805902 cites W2358421111 @default.
- W3188805902 cites W2466401299 @default.
- W3188805902 cites W2515907523 @default.
- W3188805902 cites W2556504743 @default.
- W3188805902 cites W2606753082 @default.
- W3188805902 cites W2610268183 @default.
- W3188805902 cites W2613900373 @default.
- W3188805902 cites W2735043467 @default.
- W3188805902 cites W2737085072 @default.
- W3188805902 cites W2889876526 @default.
- W3188805902 cites W2892743459 @default.
- W3188805902 cites W2894131907 @default.
- W3188805902 cites W2923054902 @default.
- W3188805902 cites W2950891256 @default.
- W3188805902 cites W2953387368 @default.
- W3188805902 cites W2962873668 @default.
- W3188805902 cites W2983410121 @default.
- W3188805902 cites W2986681854 @default.
- W3188805902 cites W2992630846 @default.
- W3188805902 cites W2995680470 @default.
- W3188805902 cites W2998856808 @default.
- W3188805902 cites W3006144768 @default.
- W3188805902 cites W3014319460 @default.
- W3188805902 cites W3033918964 @default.
- W3188805902 cites W3036031929 @default.
- W3188805902 cites W3118601047 @default.
- W3188805902 cites W3128363499 @default.
- W3188805902 cites W3139247070 @default.
- W3188805902 cites W4210457135 @default.