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• W3188853485 endingPage "103199" @default.
• W3188853485 startingPage "103199" @default.
• W3188853485 abstract "Transcription-replication conflicts (TRCs) represent a potential source of endogenous replication stress (RS) and genomic instability in eukaryotic cells but the mechanisms that underlie this instability remain poorly understood. Part of the problem could come from non-B DNA structures called R-loops, which are formed of a RNA:DNA hybrid and a displaced ssDNA loop. In this review, we discuss different scenarios in which R-loops directly or indirectly interfere with DNA replication. We also present other types of TRCs that may not depend on R-loops to impede fork progression. Finally, we discuss alternative models in which toxic RNA:DNA hybrids form at stalled forks as a consequence - but not a cause - of replication stress and interfere with replication resumption." @default.
• W3188853485 created "2021-08-16" @default.
• W3188853485 creator A5012127472 @default.
• W3188853485 creator A5020478312 @default.
• W3188853485 creator A5026906183 @default.
• W3188853485 creator A5029186772 @default.
• W3188853485 creator A5084793955 @default.
• W3188853485 date "2021-11-01" @default.
• W3188853485 modified "2023-10-10" @default.
• W3188853485 title "Toxic R-loops: Cause or consequence of replication stress?" @default.
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