FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3188923472> ?p ?o ?g. }

• W3188923472 endingPage "114493" @default.
• W3188923472 startingPage "114493" @default.
• W3188923472 abstract "Chamaecyparis obtusa (Siebold & Zucc.) Endl. (C. obtusa) has been used as folk medicine in East Asia and has been reported to alleviate inflammatory diseases. However, the detailed mechanisms for the anti-inflammatory effects of C. obtusa remain unclear.Although the anti-inflammatory mechanisms of natural products have been studied for decades, it is still important to identify the potential anti-inflammatory effects of natural sources. In this study, we investigated the anti-inflammatory effects and underlying mechanism of C. obtusa leaf extracts.The cell viability was determined by MTT and crystal violet staining. NO production in the supernatant was measured using Griess reagent. The cell lysates were analyzed by immunoblotting and RT-qPCR. Secreted cytokines were analyzed using ELISA kit and cytokine array kit. mRNA expression from the GSE9632 database set. Z-scores were calculated for each gene and visualized by heat map.Among the extracts of C. obtusa obtained with different extraction methods, the 99% ethanol leaf extract (CO99EL) strongly inhibited lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression and Janus kinase/signaling transducer and activator of transcription (JAK/STAT) phosphorylation in RAW264.7 cells. In addition, CO99EL strongly inhibited LPS-induced interleukin (IL)-1β, IL-6, IL-27, and C-C motif chemokine ligand (CCL)-1 production and directly inhibited LPS-induced JAK/STAT phosphorylation in RAW264.7 cells.These findings demonstrate that CO99EL significantly prevents LPS-induced macrophage activation by inhibiting the JAK/STAT axis. Therefore, we suggest the use of C. obtusa extracts as therapeutic approach for inflammatory diseases." @default.
• W3188923472 created "2021-08-16" @default.
• W3188923472 creator A5005739945 @default.
• W3188923472 creator A5018314666 @default.
• W3188923472 creator A5031379904 @default.
• W3188923472 creator A5046229031 @default.
• W3188923472 creator A5065350923 @default.
• W3188923472 creator A5071627434 @default.
• W3188923472 creator A5072606687 @default.
• W3188923472 creator A5074402078 @default.
• W3188923472 creator A5074425071 @default.
• W3188923472 creator A5079608933 @default.
• W3188923472 creator A5082702898 @default.
• W3188923472 date "2022-01-01" @default.
• W3188923472 modified "2023-09-25" @default.
• W3188923472 title "Chamaecyparis obtusa (Siebold & Zucc.) Endl. leaf extracts prevent inflammatory responses via inhibition of the JAK/STAT axis in RAW264.7 cells" @default.
• W3188923472 cites W1070777618 @default.
• W3188923472 cites W1655860314 @default.
• W3188923472 cites W1968596673 @default.
• W3188923472 cites W1970308473 @default.
• W3188923472 cites W1975790430 @default.
• W3188923472 cites W1991047945 @default.
• W3188923472 cites W1998470844 @default.
• W3188923472 cites W2007910341 @default.
• W3188923472 cites W2034038847 @default.
• W3188923472 cites W2044227662 @default.
• W3188923472 cites W2061228648 @default.
• W3188923472 cites W2062587829 @default.
• W3188923472 cites W2070895401 @default.
• W3188923472 cites W2076138863 @default.
• W3188923472 cites W2091508984 @default.
• W3188923472 cites W2102873430 @default.
• W3188923472 cites W2111279748 @default.
• W3188923472 cites W2118735801 @default.
• W3188923472 cites W2118742454 @default.
• W3188923472 cites W2122994040 @default.
• W3188923472 cites W2129770376 @default.
• W3188923472 cites W2132822330 @default.
• W3188923472 cites W2320473974 @default.
• W3188923472 cites W2613925863 @default.
• W3188923472 cites W2767394258 @default.
• W3188923472 cites W2786954262 @default.
• W3188923472 cites W2804508211 @default.
• W3188923472 cites W2892635078 @default.
• W3188923472 cites W2900046418 @default.
• W3188923472 cites W2979597648 @default.
• W3188923472 cites W2982662515 @default.
• W3188923472 cites W2993908729 @default.
• W3188923472 cites W3012377065 @default.
• W3188923472 cites W3016343742 @default.
• W3188923472 cites W3035034591 @default.
• W3188923472 cites W3045138750 @default.
• W3188923472 cites W3091146440 @default.
• W3188923472 cites W3121316167 @default.
• W3188923472 cites W4211144854 @default.
• W3188923472 doi "https://doi.org/10.1016/j.jep.2021.114493" @default.
• W3188923472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34364971" @default.
• W3188923472 hasPublicationYear "2022" @default.
• W3188923472 type Work @default.
• W3188923472 sameAs 3188923472 @default.
• W3188923472 citedByCount "3" @default.
• W3188923472 countsByYear W31889234722022 @default.
• W3188923472 countsByYear W31889234722023 @default.
• W3188923472 crossrefType "journal-article" @default.
• W3188923472 hasAuthorship W3188923472A5005739945 @default.
• W3188923472 hasAuthorship W3188923472A5018314666 @default.
• W3188923472 hasAuthorship W3188923472A5031379904 @default.
• W3188923472 hasAuthorship W3188923472A5046229031 @default.
• W3188923472 hasAuthorship W3188923472A5065350923 @default.
• W3188923472 hasAuthorship W3188923472A5071627434 @default.
• W3188923472 hasAuthorship W3188923472A5072606687 @default.
• W3188923472 hasAuthorship W3188923472A5074402078 @default.
• W3188923472 hasAuthorship W3188923472A5074425071 @default.
• W3188923472 hasAuthorship W3188923472A5079608933 @default.
• W3188923472 hasAuthorship W3188923472A5082702898 @default.
• W3188923472 hasBestOaLocation W31889234721 @default.
• W3188923472 hasConcept C112392421 @default.
• W3188923472 hasConcept C153911025 @default.
• W3188923472 hasConcept C157333092 @default.
• W3188923472 hasConcept C181199279 @default.
• W3188923472 hasConcept C185592680 @default.
• W3188923472 hasConcept C203014093 @default.
• W3188923472 hasConcept C2776621788 @default.
• W3188923472 hasConcept C2777622882 @default.
• W3188923472 hasConcept C2778690821 @default.
• W3188923472 hasConcept C42362537 @default.
• W3188923472 hasConcept C55493867 @default.
• W3188923472 hasConcept C59822182 @default.
• W3188923472 hasConcept C62478195 @default.
• W3188923472 hasConcept C86803240 @default.
• W3188923472 hasConcept C98274493 @default.
• W3188923472 hasConceptScore W3188923472C112392421 @default.
• W3188923472 hasConceptScore W3188923472C153911025 @default.
• W3188923472 hasConceptScore W3188923472C157333092 @default.
• W3188923472 hasConceptScore W3188923472C181199279 @default.
• W3188923472 hasConceptScore W3188923472C185592680 @default.
• W3188923472 hasConceptScore W3188923472C203014093 @default.
• W3188923472 hasConceptScore W3188923472C2776621788 @default.

• next