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- W3188948283 endingPage "e11581" @default.
- W3188948283 startingPage "e11581" @default.
- W3188948283 abstract "Sumoylation is the post-translational modification that is involved in the adaption of the cells and the functional properties of a large number of proteins. Sumoylation has key importance in subcellular concentration, transcriptional synchronization, chromatin remodeling, response to stress, and regulation of mitosis. Sumoylation is associated with developmental defects in many human diseases such as cancer, Huntington’s, Alzheimer’s, Parkinson’s, Spin cerebellar ataxia 1, and amyotrophic lateral sclerosis. The covalent bonding of Sumoylation is essential to inheriting part of the operative characteristics of some other proteins. For that reason, the prediction of the Sumoylation site has significance in the scientific community. A novel and efficient technique is proposed to predict the Sumoylation sites in proteins by incorporating Chou’s Pseudo Amino Acid Composition (PseAAC) with statistical moments-based features. The outcomes from the proposed system using 10 fold cross-validation testing are 94.51%, 94.24%, 94.79% and 0.8903% accuracy, sensitivity, specificity and MCC, respectively. The performance of the proposed system is so far the best in comparison to the other state-of-the-art methods. The codes for the current study are available on the GitHub repository using the link: https://github.com/csbioinfopk/iSumoK-PseAAC ." @default.
- W3188948283 created "2021-08-16" @default.
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- W3188948283 creator A5056591641 @default.
- W3188948283 creator A5075858344 @default.
- W3188948283 date "2021-08-04" @default.
- W3188948283 modified "2023-10-17" @default.
- W3188948283 title "iSUMOK-PseAAC: prediction of lysine sumoylation sites using statistical moments and Chou’s PseAAC" @default.
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- W3188948283 doi "https://doi.org/10.7717/peerj.11581" @default.
- W3188948283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8349168" @default.
- W3188948283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34430072" @default.
- W3188948283 hasPublicationYear "2021" @default.
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