FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3188961448> ?p ?o ?g. }

• W3188961448 endingPage "448" @default.
• W3188961448 startingPage "429" @default.
• W3188961448 abstract "About 40%-70% of the patients with treatment-resistant schizophrenia have a poor response to adequate treatment with clozapine. The impact of clozapine-resistant schizophrenia (CRS) is even greater than that of treatment resistance in terms of severe and persistent symptoms, relapses and hospitalizations, poorer quality of life, and healthcare costs. Such serious consequences often compel clinicians to try different augmentation strategies to enhance the inadequate clozapine response in CRS. Unfortunately, a large body of evidence has shown that antipsychotics, antidepressants, mood stabilizers, electroconvulsive therapy, and cognitive-behavioural therapy are mostly ineffective in augmenting clozapine response. When beneficial effects of augmentation have been found, they are usually small and of doubtful clinical significance or based on low-quality evidence. Therefore, newer treatment approaches that go beyond the evidence are needed. The options proposed include developing a clinical consensus about the augmentation strategies that are most likely to be effective and using them sequentially in patients with CRS. Secondly, newer approaches such as augmentation with long-acting antipsychotic injections or multi-component psychosocial interventions could be considered. Lastly, perhaps the most effective way to deal with CRS would be to optimize clozapine treatment, which might prevent clozapine resistance from developing. Personalized dosing, adequate treatment durations, management of side effects and non-adherence, collaboration with patients and caregivers, and addressing clinician barriers to clozapine use are the principal ways of ensuring optimal clozapine treatment. At present, these three options could the best way to manage CRS until research provides more firm directions about the effective options for augmenting clozapine response." @default.
• W3188961448 created "2021-08-16" @default.
• W3188961448 creator A5034875707 @default.
• W3188961448 date "2021-08-19" @default.
• W3188961448 modified "2023-09-29" @default.
• W3188961448 title "Clozapine resistant schizophrenia: Newer avenues of management" @default.
• W3188961448 cites W153506338 @default.
• W3188961448 cites W1679992838 @default.
• W3188961448 cites W181223444 @default.
• W3188961448 cites W1835966027 @default.
• W3188961448 cites W1907403440 @default.
• W3188961448 cites W1927353980 @default.
• W3188961448 cites W1964438525 @default.
• W3188961448 cites W1965022239 @default.
• W3188961448 cites W1967358927 @default.
• W3188961448 cites W1978991003 @default.
• W3188961448 cites W1981497986 @default.
• W3188961448 cites W1981639809 @default.
• W3188961448 cites W1982716212 @default.
• W3188961448 cites W1984670862 @default.
• W3188961448 cites W1995380902 @default.
• W3188961448 cites W1998347564 @default.
• W3188961448 cites W1998603928 @default.
• W3188961448 cites W1999020918 @default.
• W3188961448 cites W2003809619 @default.
• W3188961448 cites W2003930934 @default.
• W3188961448 cites W200434173 @default.
• W3188961448 cites W2021968198 @default.
• W3188961448 cites W2022481935 @default.
• W3188961448 cites W2032801447 @default.
• W3188961448 cites W2034403101 @default.
• W3188961448 cites W2036480935 @default.
• W3188961448 cites W2044174136 @default.
• W3188961448 cites W2044675450 @default.
• W3188961448 cites W2045335182 @default.
• W3188961448 cites W2046948383 @default.
• W3188961448 cites W2047508973 @default.
• W3188961448 cites W2048713840 @default.
• W3188961448 cites W2049502922 @default.
• W3188961448 cites W2055817483 @default.
• W3188961448 cites W2058018096 @default.
• W3188961448 cites W2059808755 @default.
• W3188961448 cites W2060442024 @default.
• W3188961448 cites W2066357241 @default.
• W3188961448 cites W2068802937 @default.
• W3188961448 cites W2070091349 @default.
• W3188961448 cites W2077169327 @default.
• W3188961448 cites W2078401005 @default.
• W3188961448 cites W2094718303 @default.
• W3188961448 cites W2097225903 @default.
• W3188961448 cites W2101126028 @default.
• W3188961448 cites W2101644005 @default.
• W3188961448 cites W2103746389 @default.
• W3188961448 cites W2106675797 @default.
• W3188961448 cites W2107625293 @default.
• W3188961448 cites W2113463828 @default.
• W3188961448 cites W2116041393 @default.
• W3188961448 cites W2121458109 @default.
• W3188961448 cites W2123069664 @default.
• W3188961448 cites W2128504520 @default.
• W3188961448 cites W2130848936 @default.
• W3188961448 cites W2133743804 @default.
• W3188961448 cites W2136273051 @default.
• W3188961448 cites W2136845281 @default.
• W3188961448 cites W2139266677 @default.
• W3188961448 cites W2142450035 @default.
• W3188961448 cites W2146134699 @default.
• W3188961448 cites W2147668060 @default.
• W3188961448 cites W2157127087 @default.
• W3188961448 cites W2160096204 @default.
• W3188961448 cites W2164047304 @default.
• W3188961448 cites W2168985903 @default.
• W3188961448 cites W2175466887 @default.
• W3188961448 cites W2200934374 @default.
• W3188961448 cites W2283214644 @default.
• W3188961448 cites W2314918267 @default.
• W3188961448 cites W2316699088 @default.
• W3188961448 cites W2408755897 @default.
• W3188961448 cites W2419119392 @default.
• W3188961448 cites W2436128242 @default.
• W3188961448 cites W2474685116 @default.
• W3188961448 cites W2480374316 @default.
• W3188961448 cites W2511002456 @default.
• W3188961448 cites W2515404667 @default.
• W3188961448 cites W2527103551 @default.
• W3188961448 cites W2533481703 @default.
• W3188961448 cites W2535297165 @default.
• W3188961448 cites W2560738057 @default.
• W3188961448 cites W2560754155 @default.
• W3188961448 cites W2580347876 @default.
• W3188961448 cites W2582499961 @default.
• W3188961448 cites W2591869572 @default.
• W3188961448 cites W2601572647 @default.
• W3188961448 cites W2612895336 @default.
• W3188961448 cites W2616114255 @default.
• W3188961448 cites W2623053349 @default.
• W3188961448 cites W2714287629 @default.
• W3188961448 cites W2729856336 @default.

• next