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• W3189041782 endingPage "105928" @default.
• W3189041782 startingPage "105928" @default.
• W3189041782 abstract "• Developmental morphological effects of PM 2.5 were explored in zebrafish embryos. • Most embryos exposed to PM 2.5 exhibited hatching delays and mortality. • PM 2.5 caused pericardial edema and string heartbeats through blood circulation failure. • PM 2.5 caused apoptosis, disruption of the vascular system and liver, and inhibited motor neurons. • PM 2.5 disturbed the cellular and subcellular organelles in developing zebrafish. Contemporary research in epidemiology has found that being exposed to air pollution at an early stage of life has associations with both acute and chronic conditions of multi-organs. Nevertheless, the reasons for this have yet to be fully explained. Because of this there is a need for a robust investigation into the damaging toxic influence of diesel particulate matter (PM 2.5 ) on living organisms. This study is aimed to investigate the developmental toxicity of PM 2.5 by using zebrafish ( Danio rerio ) embryo/larvae as a disease model and to understand the toxicity effects of PM 2.5 on ecological environment more thoroughly. This research demonstrates that being exposed to PM 2.5 leads to a significant increase in mortality, variation in developmental morphology, reduction in hatching rate and heart rate in zebrafish. Additionally, it leads to increases in the length of string heart, area of pericardium, and apoptosis, reduces the number of normal intersegmental vessels (ISVs) and motor neurons in the trunk region and liver formation defects in zebrafish embryos. Investigation employing a scanning electron microscope demonstrates that being exposed to PM 2.5 leads to damage in zebrafish larvae skin cell layers. Histological analysis demonstrates that when these larvae are treated with PM 2.5 abnormalities occur in the neurons, liver, heart, gills, brain, and eyes, and remarkable increase in the cellular/subcellular levels of organelle dissolution. These findings are useful to help us understand the pathophysiological influence of being exposed to PM 2.5 on the multi-organ defects of zebrafish. More research into which particular elements that make up diesel pollution contribute to this toxicity is needed so that the dangers to development can be further analysed." @default.
• W3189041782 created "2021-08-16" @default.
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• W3189041782 date "2021-09-01" @default.
• W3189041782 modified "2023-09-24" @default.
• W3189041782 title "Developmental toxicity induced by particulate matter (PM2.5) in zebrafish (Danio rerio) model" @default.
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• W3189041782 doi "https://doi.org/10.1016/j.aquatox.2021.105928" @default.
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• W3189041782 hasPublicationYear "2021" @default.
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