Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189058568> ?p ?o ?g. }
- W3189058568 endingPage "819" @default.
- W3189058568 startingPage "819" @default.
- W3189058568 abstract "Major depressive disorder (MDD) and bipolar disorder (BD) are often chronic with many patients not responding to available treatments. As these mood disorders are frequently associated with metabolic dysfunction, there has been increased interest in novel treatments that would target metabolic pathways. The objectives of this scoping review were to synthesize evidence on the impact on mood symptoms of lipid lowering agents and anti-diabetics drugs, while also reviewing current knowledge on the association between mood disorders and dyslipidemia or hyperglycemia. We propose that metabolic dysfunction is prevalent in both MDD and BD and it may contribute to the development of these disorders through a variety of pathophysiological processes including inflammation, brain structural changes, hormonal alterations, neurotransmitter disruptions, alteration on brain cholesterol, central insulin resistance, and changes in gut microbiota. Current evidence is conflicting on the use of statins, polyunsaturated fatty acids, thiazolidinediones, glucagon-like peptide agonists, metformin, or insulin for the treatment of MDD and BD. Given the paucity of high-quality randomized controlled trials, additional studies are needed before any of these medications can be repurposed in routine clinical practice. Future trials need to enrich patient recruitment, include evaluations of mechanism of action, and explore differential effects on specific symptom domains such as anhedonia, suicidality, and cognition." @default.
- W3189058568 created "2021-08-16" @default.
- W3189058568 creator A5019144619 @default.
- W3189058568 creator A5019562259 @default.
- W3189058568 creator A5039234509 @default.
- W3189058568 creator A5047723483 @default.
- W3189058568 creator A5079504997 @default.
- W3189058568 date "2021-08-11" @default.
- W3189058568 modified "2023-10-17" @default.
- W3189058568 title "Targeting Metabolic Dysfunction for the Treatment of Mood Disorders: Review of the Evidence" @default.
- W3189058568 cites W1191165180 @default.
- W3189058568 cites W1539151695 @default.
- W3189058568 cites W1794396397 @default.
- W3189058568 cites W1866846039 @default.
- W3189058568 cites W1901734004 @default.
- W3189058568 cites W1906082830 @default.
- W3189058568 cites W1911808475 @default.
- W3189058568 cites W1974250392 @default.
- W3189058568 cites W1986084664 @default.
- W3189058568 cites W1990532967 @default.
- W3189058568 cites W1999999989 @default.
- W3189058568 cites W2003494755 @default.
- W3189058568 cites W2007015427 @default.
- W3189058568 cites W2007094369 @default.
- W3189058568 cites W2009064331 @default.
- W3189058568 cites W2012450128 @default.
- W3189058568 cites W2017644516 @default.
- W3189058568 cites W2017680611 @default.
- W3189058568 cites W2020470831 @default.
- W3189058568 cites W2025945391 @default.
- W3189058568 cites W2027837001 @default.
- W3189058568 cites W2029191095 @default.
- W3189058568 cites W2033138490 @default.
- W3189058568 cites W2033824363 @default.
- W3189058568 cites W2039411479 @default.
- W3189058568 cites W2044831296 @default.
- W3189058568 cites W2046667801 @default.
- W3189058568 cites W2049839333 @default.
- W3189058568 cites W2057091987 @default.
- W3189058568 cites W2057242026 @default.
- W3189058568 cites W2058656676 @default.
- W3189058568 cites W2058717577 @default.
- W3189058568 cites W2065014634 @default.
- W3189058568 cites W2065522644 @default.
- W3189058568 cites W2067369841 @default.
- W3189058568 cites W2067694641 @default.
- W3189058568 cites W2069494503 @default.
- W3189058568 cites W2075787882 @default.
- W3189058568 cites W2078320157 @default.
- W3189058568 cites W2079344641 @default.
- W3189058568 cites W2080667948 @default.
- W3189058568 cites W2080967766 @default.
- W3189058568 cites W2082823754 @default.
- W3189058568 cites W2086168349 @default.
- W3189058568 cites W2091044076 @default.
- W3189058568 cites W2100554696 @default.
- W3189058568 cites W2101198536 @default.
- W3189058568 cites W2102279279 @default.
- W3189058568 cites W2106129883 @default.
- W3189058568 cites W2122071420 @default.
- W3189058568 cites W2122508226 @default.
- W3189058568 cites W2123042728 @default.
- W3189058568 cites W2123541107 @default.
- W3189058568 cites W2123937038 @default.
- W3189058568 cites W2124852816 @default.
- W3189058568 cites W2125344994 @default.
- W3189058568 cites W2130194207 @default.
- W3189058568 cites W2132324173 @default.
- W3189058568 cites W2146742006 @default.
- W3189058568 cites W2146852649 @default.
- W3189058568 cites W2153352631 @default.
- W3189058568 cites W2154236525 @default.
- W3189058568 cites W2160313172 @default.
- W3189058568 cites W2172062051 @default.
- W3189058568 cites W2336923172 @default.
- W3189058568 cites W2490010298 @default.
- W3189058568 cites W2520033666 @default.
- W3189058568 cites W2527740737 @default.
- W3189058568 cites W2547251644 @default.
- W3189058568 cites W2560292653 @default.
- W3189058568 cites W2561399360 @default.
- W3189058568 cites W2570413596 @default.
- W3189058568 cites W2585030762 @default.
- W3189058568 cites W2787646573 @default.
- W3189058568 cites W2792374913 @default.
- W3189058568 cites W2842106704 @default.
- W3189058568 cites W2891593039 @default.
- W3189058568 cites W2901788822 @default.
- W3189058568 cites W2912815879 @default.
- W3189058568 cites W2914529824 @default.
- W3189058568 cites W2921277342 @default.
- W3189058568 cites W2965334743 @default.
- W3189058568 cites W2970939804 @default.
- W3189058568 cites W2988542011 @default.
- W3189058568 cites W3004924742 @default.
- W3189058568 cites W3010473468 @default.
- W3189058568 cites W3027225672 @default.
- W3189058568 cites W3033172924 @default.