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- W3189085402 endingPage "504" @default.
- W3189085402 startingPage "494" @default.
- W3189085402 abstract "Heart failure (HF) has continued to be a leading cause of morbidity and mortality worldwide. Nanomedicine, which can deliver therapeutic drugs/biomolecules specifically to damaged myocardium and overcome the limitations of conventional therapies, shows great potential in the treatment of HF. Although a number of preclinical studies of cardiac nanoformulations have been published, targeted nanomedicine for HF is yet to be applied in clinical practice. Therefore, it is meaningful to sum up past experiences and deepen the understanding of nanomedicine and HF. In this review, we first emphasized the key biological barriers to cardiac nanomedicine that hinder its targeting effect. Since the rational design of nanoparticles should take into account the specific characteristics of HF, we then summarized the key pathophysiological changes of HF to provide a clear understanding on HF, as well as the latest examples of nanotechnology-based delivery strategies for different pathophysiological characteristics. Finally, the major challenges are discussed in detail, aiming to provide guidance for future development of cardiac nanomedicine." @default.
- W3189085402 created "2021-08-16" @default.
- W3189085402 creator A5012427149 @default.
- W3189085402 creator A5038261237 @default.
- W3189085402 creator A5080552560 @default.
- W3189085402 date "2021-09-01" @default.
- W3189085402 modified "2023-10-16" @default.
- W3189085402 title "Advance cardiac nanomedicine by targeting the pathophysiological characteristics of heart failure" @default.
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