Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189088669> ?p ?o ?g. }
- W3189088669 endingPage "113514" @default.
- W3189088669 startingPage "113514" @default.
- W3189088669 abstract "Vocal communication impairment and anxiety are co-occurring and interacting signs of Parkinson Disease (PD) that are common, poorly understood, and under-treated. Both vocal communication and anxiety are influenced by the noradrenergic system. In light of this shared neural substrate and considering that noradrenergic dysfunction is a defining characteristic of PD, tandem investigation of vocal impairment and anxiety in PD relative to noradrenergic mechanisms is likely to yield insights into the underlying disease-specific causes of these impairments. In order to address this gap in knowledge, we assessed vocal impairment and anxiety behavior relative to brainstem noradrenergic markers in a genetic rat model of early-onset PD (Pink1-/-) and wild type controls (WT). We hypothesized that 1) brainstem noradrenergic markers would be disrupted in Pink1-/-, and 2) brainstem noradrenergic markers would be associated with vocal acoustic changes and anxiety level. Rats underwent testing of ultrasonic vocalization and anxiety (elevated plus maze) at 4, 8, and 12 months of age. At 12 months, brainstem norepinephrine markers were quantified with immunohistochemistry. Results demonstrated that vocal impairment and anxiety were increased in Pink1-/- rats, and increased anxiety was associated with greater vocal deficit in this model of PD. Further, brainstem noradrenergic markers including TH and α1 adrenoreceptor immunoreactivity in the locus coeruleus, and β1 adrenoreceptor immunoreactivity in vagal nuclei differed by genotype, and were associated with vocalization and anxiety behavior. These findings demonstrate statistically significant relationships among vocal impairment, anxiety, and brainstem norepinephrine in the Pink1-/- rat model of PD." @default.
- W3189088669 created "2021-08-16" @default.
- W3189088669 creator A5050710492 @default.
- W3189088669 creator A5051650366 @default.
- W3189088669 creator A5060799432 @default.
- W3189088669 date "2021-09-01" @default.
- W3189088669 modified "2023-10-16" @default.
- W3189088669 title "Quantification of brainstem norepinephrine relative to vocal impairment and anxiety in the Pink1-/- rat model of Parkinson disease" @default.
- W3189088669 cites W1023607167 @default.
- W3189088669 cites W1418662746 @default.
- W3189088669 cites W1499787223 @default.
- W3189088669 cites W1533056363 @default.
- W3189088669 cites W1572276522 @default.
- W3189088669 cites W1581652555 @default.
- W3189088669 cites W1604114751 @default.
- W3189088669 cites W1761627028 @default.
- W3189088669 cites W1801340045 @default.
- W3189088669 cites W1827984733 @default.
- W3189088669 cites W1871979774 @default.
- W3189088669 cites W1922869549 @default.
- W3189088669 cites W1964160578 @default.
- W3189088669 cites W1965250454 @default.
- W3189088669 cites W1966556489 @default.
- W3189088669 cites W1975656289 @default.
- W3189088669 cites W1976749972 @default.
- W3189088669 cites W1980129559 @default.
- W3189088669 cites W1986400202 @default.
- W3189088669 cites W1990514317 @default.
- W3189088669 cites W1991132625 @default.
- W3189088669 cites W1996074077 @default.
- W3189088669 cites W1997296067 @default.
- W3189088669 cites W1999385317 @default.
- W3189088669 cites W2000123680 @default.
- W3189088669 cites W2001079483 @default.
- W3189088669 cites W2002479772 @default.
- W3189088669 cites W2007697742 @default.
- W3189088669 cites W2012556157 @default.
- W3189088669 cites W2014831739 @default.
- W3189088669 cites W2014897379 @default.
- W3189088669 cites W2017848953 @default.
- W3189088669 cites W2019507350 @default.
- W3189088669 cites W2022533807 @default.
- W3189088669 cites W2024165070 @default.
- W3189088669 cites W2025158103 @default.
- W3189088669 cites W2026113561 @default.
- W3189088669 cites W2029696922 @default.
- W3189088669 cites W2030671770 @default.
- W3189088669 cites W2032900710 @default.
- W3189088669 cites W2033560214 @default.
- W3189088669 cites W2034728437 @default.
- W3189088669 cites W2041561931 @default.
- W3189088669 cites W2043039711 @default.
- W3189088669 cites W2043538284 @default.
- W3189088669 cites W2050948071 @default.
- W3189088669 cites W2054081268 @default.
- W3189088669 cites W2059538297 @default.
- W3189088669 cites W2066792768 @default.
- W3189088669 cites W2067590452 @default.
- W3189088669 cites W2067930310 @default.
- W3189088669 cites W2068100950 @default.
- W3189088669 cites W2072350503 @default.
- W3189088669 cites W2073449985 @default.
- W3189088669 cites W2074731424 @default.
- W3189088669 cites W2076274207 @default.
- W3189088669 cites W2077880694 @default.
- W3189088669 cites W2079714688 @default.
- W3189088669 cites W2083649541 @default.
- W3189088669 cites W2084614861 @default.
- W3189088669 cites W2085838792 @default.
- W3189088669 cites W2092067328 @default.
- W3189088669 cites W2092882526 @default.
- W3189088669 cites W2094125339 @default.
- W3189088669 cites W2095127925 @default.
- W3189088669 cites W2101837521 @default.
- W3189088669 cites W2104088527 @default.
- W3189088669 cites W2111405228 @default.
- W3189088669 cites W2117150032 @default.
- W3189088669 cites W2121594879 @default.
- W3189088669 cites W2122835755 @default.
- W3189088669 cites W2131361751 @default.
- W3189088669 cites W2145875022 @default.
- W3189088669 cites W2148103616 @default.
- W3189088669 cites W2158625734 @default.
- W3189088669 cites W2160409616 @default.
- W3189088669 cites W2161149320 @default.
- W3189088669 cites W2163211496 @default.
- W3189088669 cites W2166211493 @default.
- W3189088669 cites W2179737758 @default.
- W3189088669 cites W2192027741 @default.
- W3189088669 cites W2256350297 @default.
- W3189088669 cites W2283621823 @default.
- W3189088669 cites W2305054986 @default.
- W3189088669 cites W2318613086 @default.
- W3189088669 cites W2331580166 @default.
- W3189088669 cites W2344074899 @default.
- W3189088669 cites W2417048044 @default.
- W3189088669 cites W2437516934 @default.
- W3189088669 cites W2560443639 @default.