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- W3189096922 endingPage "112281" @default.
- W3189096922 startingPage "112281" @default.
- W3189096922 abstract "Photobiomodulation (PBM) has been applied as a non-invasive technique for treating temporomandibular joint symptoms, especially on painful condition's relief, however the anti-inflammatory mechanism underlying the effect of PBM remains uncertain. This study aims to evaluate the mechanisms of action of PBM (808 nm) in a carrageenan-induced inflammation on temporomandibular joint (TMJ) of rats. In this study male Wistar rats were pre-treated with irradiation of a low-power diode laser for 15 s on TMJ (infra-red 808 nm, 100 mW, 50 J/cm 2 and 1.5 J) 15 min prior an injection in the temporomandibular joint of carrageenan (100 μg/TMJ). 1 h after the TMJ treatments, the rats were terminally anesthetized for joint cavity wash and periarticular tissues collect. Samples analysis demonstrated that PBM inhibit leukocytes chemotaxis in the TMJ and significantly reduces amounts of TNF-α, IL-1β and CINC-1. In addition, Western blotting analysis demonstrated that PBM significantly decreased the protein levels of P2X3 and P2X7 receptors in the periarticular tissues. On the other hand, PBM was able to increase protein level of IL-10 (anti-inflammatory cytokine). In summary, it is possible to suggest that PBM inhibit inflammatory chemotaxis, modulation the balance of the pro- and anti-inflammatory characteristics of inflammatory cells. • PBM prevents inflammatory chemotaxis in a carrageenan-induced inflammation on TMJ. • Levels of pro-inflammatory cytokines (TNF-α, IL-1β and CINC-1) are reduced with PBM. • Levels of IL-10 (anti-inflammatory cytokine) are increased with PBM. • PBM decreased protein levels of purinergic receptors (P2X3 and P2X7) on TMJ." @default.
- W3189096922 created "2021-08-16" @default.
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- W3189096922 creator A5053882272 @default.
- W3189096922 creator A5074398308 @default.
- W3189096922 creator A5079911754 @default.
- W3189096922 date "2021-09-01" @default.
- W3189096922 modified "2023-09-26" @default.
- W3189096922 title "Photobiomodulation inhibits inflammation in the temporomandibular joint of rats" @default.
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- W3189096922 doi "https://doi.org/10.1016/j.jphotobiol.2021.112281" @default.
- W3189096922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34388640" @default.
- W3189096922 hasPublicationYear "2021" @default.
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