FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189134408> ?p ?o ?g. }

• W3189134408 abstract "Malaria parasite transmission to mosquitoes relies on the uptake of sexual stage parasites during a blood meal and subsequent formation of oocysts on the mosquito midgut wall. Transmission-blocking vaccines (TBVs) and monoclonal antibodies (mAbs) target sexual stage antigens to interrupt human-to-mosquito transmission and may form important tools for malaria elimination. Although most epitopes of these antigens are considered highly conserved, little is known about the impact of natural genetic diversity on the functional activity of transmission-blocking antibodies. Here we measured the efficacy of three mAbs against leading TBV candidates (Pfs48/45, Pfs25 and Pfs230) in transmission assays with parasites from naturally infected donors compared to their efficacy against the strain they were raised against (NF54). Transmission-reducing activity (TRA) was measured as reduction in mean oocyst intensity. mAb 45.1 (α-Pfs48/45) and mAb 4B7 (α-Pfs25) reduced transmission of field parasites from almost all donors with IC80 values similar to NF54. Sequencing of oocysts that survived high mAb concentrations did not suggest enrichment of escape genotypes. mAb 2A2 (α-Pfs230) only reduced transmission of parasites from a minority of the donors, suggesting that it targets a non-conserved epitope. Using six laboratory-adapted strains, we revealed that mutations in one Pfs230 domain correlate with mAb gamete surface binding and functional TRA. Our findings demonstrate that, despite the conserved nature of sexual stage antigens, minor sequence variation can significantly impact the efficacy of transmission-blocking mAbs. Since mAb 45.1 shows high potency against genetically diverse strains, our findings support its further clinical development and may inform Pfs48/45 vaccine design." @default.
• W3189134408 created "2021-08-16" @default.
• W3189134408 creator A5000630657 @default.
• W3189134408 creator A5010246466 @default.
• W3189134408 creator A5017781000 @default.
• W3189134408 creator A5036352618 @default.
• W3189134408 creator A5036396443 @default.
• W3189134408 creator A5040219106 @default.
• W3189134408 creator A5043039142 @default.
• W3189134408 creator A5046009741 @default.
• W3189134408 creator A5056044954 @default.
• W3189134408 creator A5059548173 @default.
• W3189134408 creator A5060874079 @default.
• W3189134408 creator A5062388626 @default.
• W3189134408 creator A5063536546 @default.
• W3189134408 creator A5073424910 @default.
• W3189134408 creator A5076495245 @default.
• W3189134408 creator A5086852221 @default.
• W3189134408 creator A5088203489 @default.
• W3189134408 date "2021-08-12" @default.
• W3189134408 modified "2023-09-30" @default.
• W3189134408 title "Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes" @default.
• W3189134408 cites W1483396785 @default.
• W3189134408 cites W1963097328 @default.
• W3189134408 cites W1966185179 @default.
• W3189134408 cites W1982332926 @default.
• W3189134408 cites W1991469620 @default.
• W3189134408 cites W1994983502 @default.
• W3189134408 cites W2003852785 @default.
• W3189134408 cites W2004056126 @default.
• W3189134408 cites W2005735129 @default.
• W3189134408 cites W2015107346 @default.
• W3189134408 cites W2019171382 @default.
• W3189134408 cites W2028126135 @default.
• W3189134408 cites W2067447412 @default.
• W3189134408 cites W2074905094 @default.
• W3189134408 cites W2080689553 @default.
• W3189134408 cites W2083280521 @default.
• W3189134408 cites W2086852608 @default.
• W3189134408 cites W2094048666 @default.
• W3189134408 cites W2105319966 @default.
• W3189134408 cites W2132243766 @default.
• W3189134408 cites W2138155689 @default.
• W3189134408 cites W2140911148 @default.
• W3189134408 cites W2158266834 @default.
• W3189134408 cites W2160412078 @default.
• W3189134408 cites W2166331848 @default.
• W3189134408 cites W2167100631 @default.
• W3189134408 cites W2170277594 @default.
• W3189134408 cites W2210238778 @default.
• W3189134408 cites W2223960065 @default.
• W3189134408 cites W2381153372 @default.
• W3189134408 cites W2484762910 @default.
• W3189134408 cites W2536285012 @default.
• W3189134408 cites W2628128619 @default.
• W3189134408 cites W2738931180 @default.
• W3189134408 cites W2754855881 @default.
• W3189134408 cites W2763907629 @default.
• W3189134408 cites W2772777925 @default.
• W3189134408 cites W2773685302 @default.
• W3189134408 cites W2775244680 @default.
• W3189134408 cites W2791741332 @default.
• W3189134408 cites W2799562692 @default.
• W3189134408 cites W2805197529 @default.
• W3189134408 cites W2883669154 @default.
• W3189134408 cites W2885422062 @default.
• W3189134408 cites W2896243600 @default.
• W3189134408 cites W2904720295 @default.
• W3189134408 cites W2938574745 @default.
• W3189134408 cites W2954428213 @default.
• W3189134408 cites W2975047170 @default.
• W3189134408 cites W2996314987 @default.
• W3189134408 cites W3004146881 @default.
• W3189134408 cites W3110330792 @default.
• W3189134408 cites W3137319547 @default.
• W3189134408 cites W4230252161 @default.
• W3189134408 cites W4252534598 @default.
• W3189134408 cites W2907899503 @default.
• W3189134408 doi "https://doi.org/10.1038/s41541-021-00366-9" @default.
• W3189134408 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8361195" @default.
• W3189134408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34385463" @default.
• W3189134408 hasPublicationYear "2021" @default.
• W3189134408 type Work @default.
• W3189134408 sameAs 3189134408 @default.
• W3189134408 citedByCount "18" @default.
• W3189134408 countsByYear W31891344082022 @default.
• W3189134408 countsByYear W31891344082023 @default.
• W3189134408 crossrefType "journal-article" @default.
• W3189134408 hasAuthorship W3189134408A5000630657 @default.
• W3189134408 hasAuthorship W3189134408A5010246466 @default.
• W3189134408 hasAuthorship W3189134408A5017781000 @default.
• W3189134408 hasAuthorship W3189134408A5036352618 @default.
• W3189134408 hasAuthorship W3189134408A5036396443 @default.
• W3189134408 hasAuthorship W3189134408A5040219106 @default.
• W3189134408 hasAuthorship W3189134408A5043039142 @default.
• W3189134408 hasAuthorship W3189134408A5046009741 @default.
• W3189134408 hasAuthorship W3189134408A5056044954 @default.
• W3189134408 hasAuthorship W3189134408A5059548173 @default.
• W3189134408 hasAuthorship W3189134408A5060874079 @default.
• W3189134408 hasAuthorship W3189134408A5062388626 @default.

• next