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- W3189161014 abstract "Escherichia coli is an obligate representative of the human intestinal microbiota, characterized by a wide intraspecific diversity, which is also reflected in the sensitivity to antimicrobial drugs. The species is represented by four main phylogenetic groups (A, B1, B2, D). 511 E. coli strains isolated from the intestinal microbiota of children aged 1 month to 17 years were studied. The susceptibility to 15 antibiotics was determined by the disco-diffusion method. The phylogenetic group of strains was determined in triplex PCR using the O. Clermont method. Genes encoding β-lactamases of the molecular classes TEM, SHV, OXA, and CTX-M were detected by multiplex PCR. The proportion of strains resistant to one or more antimicrobial classes among E. coli of phylogenetic group A was 26,9%, B1 — 18,9%, B2 — 42,4%, D — 56,2% (p < 0.001). The proportion of multidrug resistant isolates (resistant to 3 or more classes) was 10,2% in group A; 5,4% in group B1; 14,7% in group B2 and 29,9% in group D (p< 0.001). Three (TEM, SHV, STX-M) of the 4 studied β-lactamase genes and their combinations were statistically significantly more often detected in E. coli strains of group D. Conclusions. The intestinal microbiota of children is an important reservoir of E. coli resistant (including multidrug resistance) to various classes of antibiotics. The presence of β-lactamase genes and multidrug resistance are most characteristic of E. coli strains of phylogenetic group D." @default.
- W3189161014 created "2021-08-16" @default.
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- W3189161014 date "2020-01-01" @default.
- W3189161014 modified "2023-09-27" @default.
- W3189161014 title "ANTIBIOTIC RESISTANCE OF ESCHERICHIA COLI OF DIFFERENT PHYLOGENETIC GROUPS" @default.
- W3189161014 doi "https://doi.org/10.36233/978-5-9900432-9-9-73" @default.
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