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- W3189192098 abstract "Reliable molecular markers that allow the rational prescription of an effective chemotherapy type for each prostate cancer patient are still needed. Since microRNAs expression is associated with the response to different types of prostate cancer therapy, microRNAs represent a pool of perspective markers of therapy effectiveness comprising chemotherapy.The available data on microRNAs associated with chemotherapy response (resistance and sensitivity) are summarized and analyzed in the article.A review of the published data, as well as their analysis by current bioinformatics resources, was conducted. The molecular targets of microRNAs, as well as the reciprocal relationships between the microRNAs and their targets, were studied using the DIANA, STRING, and TransmiR databases. Special attention was dedicated to the mechanisms of prostate cancer chemoresistance development.The combined analysis of bioinformatics resources and the available literature indicated that the expression of eight microRNAs that are associated with different responses to chemotherapy have a high potential for the prediction of the prostate cancer chemotherapy response, as found in the experiments and confirmed by the functions of regulated genes.An overview on the published data and bioinformatics resources, with respect to predictive microRNA markers of chemotherapy response, is presented in this review. The selected microRNA and gene panel has a high potential for predicting the chemosensitivity or chemoresistance of prostate cancer and could represent a set of markers for subsequent study using samples of cell-free microRNAs from different patient groups." @default.
- W3189192098 created "2021-08-16" @default.
- W3189192098 creator A5003020611 @default.
- W3189192098 creator A5087173271 @default.
- W3189192098 date "2021-08-13" @default.
- W3189192098 modified "2023-10-16" @default.
- W3189192098 title "The miRNAs involved in prostate cancer chemotherapy response as chemoresistance and chemosensitivity predictors" @default.
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