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• W3189252331 abstract "Abstract Background Recently, human infertility incidence is increasing in obese women causing it to become an emerging global health challenge requiring improved treatment. There is extensive evidence that obesity caused female reproductive dysfunction is accompanied by an endocrinological influence. Besides, systemic and tissue-specific chronic inflammatory status are common characteristics of obesity. However, the underlying molecular mechanism is unclear linking obesity to infertility or subfertility. Methods To deal with this question, we created an obese mouse model through providing a high fat diet (HFD) and determined the fertility of the obese mice. The morphological alterations were evaluated in both the reproductive glands and tracts, such as uterus, ovary and oviduct. Furthermore, to explore the underlying mechanism of these functional changes, the expressions of pro-inflammatory cytokines as well as the activations of MAPK signaling and NF-κB signaling were detected in these reproductive tissues. Results The obese females were successful construction and displayed subfertility. They accumulated lipid droplets and developed morphological alterations in each of their reproductive organs including uterus, ovary and oviduct. These pathological changes accompanied increases in pro-inflammatory cytokine expression levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in all of these sites. Such effects also accompanied increases in nuclear factor kappa B (NF-kB) expression and mitogen-activated protein kinase (MAPK) signaling pathway stimulation based on uniform time dependent increases in the NF-κB (p-NF-κB), JNK (p-JNK), ERK1/2 (p-ERK) and p38 (p-p38) phosphorylation status. Conclusions These HFD-induced increases in pro-inflammatory cytokine expression levels and NF-κB and MAPKs signaling pathway activation in reproductive organs support the notion that increases of adipocytes resident and inflammatory status are symptomatic of female fertility impairment in obese mice." @default.
• W3189252331 created "2021-08-16" @default.
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• W3189252331 date "2021-09-24" @default.
• W3189252331 modified "2023-10-15" @default.
• W3189252331 title "Obesity induces morphological and functional changes in female reproductive system through increases in NF-κB and MAPK signaling in mice" @default.
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• W3189252331 cites W1990928485 @default.
• W3189252331 cites W1997753936 @default.
• W3189252331 cites W1998682109 @default.
• W3189252331 cites W1999710695 @default.
• W3189252331 cites W2009224756 @default.
• W3189252331 cites W2028787381 @default.
• W3189252331 cites W2038018821 @default.
• W3189252331 cites W2040477992 @default.
• W3189252331 cites W2042087846 @default.
• W3189252331 cites W2042938039 @default.
• W3189252331 cites W2046230257 @default.
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• W3189252331 doi "https://doi.org/10.1186/s12958-021-00833-x" @default.
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