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• W3189293848 endingPage "111502" @default.
• W3189293848 startingPage "111502" @default.
• W3189293848 abstract "The excessive deposition of β-amyloid proteins (Aβ) is directly correlated with the establishment and development of Alzheimer's Disease (AD). Current treatments for AD only reduce symptoms instead of acting on Aβ, the primary etiological agent. Hence, the anti-amyloid effect of regular exercise has been widely investigated as an alternative therapy. This systematic review and meta-analysis examined the anti-amyloid effect of regular physical exercise in animal models of AD. The search was conducted on the electronic databases Pubmed, Embase, Scopus and Web of Science without data limitation and using the following describers: “amyloid beta” (OR senile plaque OR amyloid plaque) and “exercise” (OR physical activity OR training). The risk of bias was evaluated using the SYRCLE's tool. Meta-analyses were conducted using models of random continuous effects. A total of 36 studies were selected and most used: transgenic mice (n = 29), treadmill training, duration of 12 weeks (interval of 4 to 28 weeks), rate of 60 min/day (interval of 30 min and up until free access) and speed of 12 m/min (interval of 3.2 to 32 m/min). The hippocampus and cortex were the most frequently investigated regions. Meta-analysis demonstrated a decrease in Aβ with greater effect in unspecified isoforms Meta-analysis demonstrated a decrease in Aβ with greater effect in unspecified isoforms (N = 4; SMD = −2.71, IC 95%: −3.59, −1.84, p < 0.00001, Q2 = 3.38, I2 = 11%) and Aβ1-42 (N = 21; SMD = −1.94, IC 95%: −2.37, −1.51, p < 0.00001, Q2 = 33,37, I2 = 40%). Concerning training, greater effect was found with: 1) swimming (N = 4; SMD = −1.98, IC 95%: −3,28 – −0,68, p = 0.003, Q2 = 9.74, I2 = 69%), 2) moderate intensity (N = 4; SMD = −2.03, IC 95%: −3.31 – −0.75, p < 0.005, Q2 = 12.68, I2 = 76%); 3) duration up to six weeks (N = 6; N = 6; SMD = −2.35, IC 95%: −3.15 – −1.55, p < 0.00001, Q2 = 8.38, I2 = 40%); 4) young animals (SMD = −2.00, IC 95%: −2.59 – −1.42, p < 0.00001, Q2 = 24.90, I2 = 52%); 5) in the amygdala region (N = 1; SMD = −8.56, IC 95%: −12.88 – −4.23, p = 0.0001) and females (N = 4; SMD = −2.14, IC 95%: −3.48 – -0.79, p = 0.002, Q2 = 10.31, I2 = 71%). However, the reduction of Aβ was associated with decrease of amyloidogenic pathway and increase of non-amyloidogenic. Hence, regular physical exercise demonstrated anti-amyloid effect in experimental models of AD through positive alterations in APP processing through different signaling pathways." @default.
• W3189293848 created "2021-08-16" @default.
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• W3189293848 date "2021-10-01" @default.
• W3189293848 modified "2023-10-18" @default.
• W3189293848 title "Effect of involuntary chronic physical exercise on beta-amyloid protein in experimental models of Alzheimer's disease: Systematic review and meta-analysis" @default.
• W3189293848 cites W1536959260 @default.
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• W3189293848 cites W1589706085 @default.
• W3189293848 cites W1750598644 @default.
• W3189293848 cites W1940862436 @default.
• W3189293848 cites W1976296246 @default.
• W3189293848 cites W1978885090 @default.
• W3189293848 cites W1986384924 @default.
• W3189293848 cites W1991559589 @default.
• W3189293848 cites W1995609628 @default.
• W3189293848 cites W2011074122 @default.
• W3189293848 cites W2016787780 @default.
• W3189293848 cites W2032213666 @default.
• W3189293848 cites W2033882308 @default.
• W3189293848 cites W2036234078 @default.
• W3189293848 cites W2042449171 @default.
• W3189293848 cites W2048992858 @default.
• W3189293848 cites W2055389152 @default.
• W3189293848 cites W2065184914 @default.
• W3189293848 cites W2068942754 @default.
• W3189293848 cites W2075721398 @default.
• W3189293848 cites W2077756886 @default.
• W3189293848 cites W2083186327 @default.
• W3189293848 cites W2084871129 @default.
• W3189293848 cites W2088134423 @default.
• W3189293848 cites W2106942857 @default.
• W3189293848 cites W2124634545 @default.
• W3189293848 cites W2126930838 @default.
• W3189293848 cites W2133845492 @default.
• W3189293848 cites W2141275828 @default.
• W3189293848 cites W2144857111 @default.
• W3189293848 cites W2147486806 @default.
• W3189293848 cites W2150999725 @default.
• W3189293848 cites W2161678021 @default.
• W3189293848 cites W2161863487 @default.
• W3189293848 cites W2170111492 @default.
• W3189293848 cites W2171250577 @default.
• W3189293848 cites W2194337194 @default.
• W3189293848 cites W2237267942 @default.
• W3189293848 cites W2318239628 @default.
• W3189293848 cites W2522682458 @default.
• W3189293848 cites W2556937192 @default.
• W3189293848 cites W2576440140 @default.
• W3189293848 cites W2585086069 @default.
• W3189293848 cites W2596555436 @default.
• W3189293848 cites W2607396427 @default.
• W3189293848 cites W2746928349 @default.
• W3189293848 cites W2767589693 @default.
• W3189293848 cites W2801233391 @default.
• W3189293848 cites W2808504196 @default.
• W3189293848 cites W2918016998 @default.
• W3189293848 cites W2922954503 @default.
• W3189293848 cites W2923369190 @default.
• W3189293848 cites W2931439260 @default.
• W3189293848 cites W2969947817 @default.
• W3189293848 cites W2974485100 @default.
• W3189293848 cites W2976163884 @default.
• W3189293848 cites W2987621213 @default.
• W3189293848 cites W2999287973 @default.
• W3189293848 cites W3010103308 @default.
• W3189293848 cites W3015896909 @default.
• W3189293848 cites W3130332687 @default.
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• W3189293848 doi "https://doi.org/10.1016/j.exger.2021.111502" @default.
• W3189293848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34339821" @default.
• W3189293848 hasPublicationYear "2021" @default.
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