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• W3189305979 abstract "House dust mite (HDM) allergens are leading causes of allergic asthma characterized by T helper 2 (Th2) responses. The lung-resident CD11b dendritic cells (DCs) play a key role in Th2 cell development in HDM-induced allergic asthma. However, the regulatory mechanism of HDM-induced CD11b DC activation remains incompletely understood. Here, we show that mice deficient in an inhibitory immunoreceptor Allergin-1 exacerbated the HDM-induced airway eosinophilia and serum IgE elevation. HDM directly stimulated lung CD11b DCs via the TLR-4-MyD88 pathway and enhanced prostaglandin E2 (PGE2) production that promoted development of Th2 cells. Allergin-1 suppressed the PGE2 production by inhibiting Syk tyrosine kinase activation through recruitment of SHP-1 in HDM-stimulated CD11b DCs, subsequently leading to negative regulation of Th2 responses. These results suggest that Allergin-1 plays an important role in the regulation of HDM-induced allergic asthma." @default.
• W3189305979 created "2021-08-16" @default.
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• W3189305979 date "2018-01-01" @default.
• W3189305979 modified "2023-09-25" @default.
• W3189305979 title "Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Th2 Responses" @default.
• W3189305979 doi "https://doi.org/10.2139/ssrn.3281658" @default.
• W3189305979 hasPublicationYear "2018" @default.
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