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- W3189331717 abstract "The objective of this study was to assess the comparative efficacy and safety of different antifungal agents used for the treatment of oropharyngeal candidiasis (OPC) in adult patients with HIV. A systematic search was performed on the four major databases (Medline, Embase, CENTRAL and Scopus) to identify randomized controlled trials (RCTs) that evaluated the efficacy of antifungal agents in HIV patients with OPC. A network meta-analysis was performed from the data extracted from the selected studies. The agents were ranked according using surface under the cumulative ranking (SUCRA). The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach was used to determine the quality of evidence. A total of 15 trials were included in the quantitative analysis involving the data from a total of 2883 participants. Fluconazole was ranked as the most effective antifungal agent to achieve clinical cure (SUCRA = 0.87) in OPC followed by posaconazole and itraconazole. Posaconazole was ranked the most efficacious agent in achieving mycological cure (SUCRA = 0.81), followed by fluconazole. While nystatin was ranked the safest, the effect estimates of none of the other systemic antifungal agents were significantly higher than fluconazole. Based on the available evidence, fluconazole can be considered as the most effective drug in the treatment of OPC among HIV-infected adults and has a favorable safety profile, followed by posaconazole." @default.
- W3189331717 created "2021-08-16" @default.
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- W3189331717 date "2021-08-05" @default.
- W3189331717 modified "2023-09-26" @default.
- W3189331717 title "Comparative Efficacy of Antifungal Agents Used in the Treatment of Oropharyngeal Candidiasis among HIV-Infected Adults: A Systematic Review and Network Meta-Analysis" @default.
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- W3189331717 cites W1965948300 @default.
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- W3189331717 cites W1967385770 @default.
- W3189331717 cites W1968475599 @default.
- W3189331717 cites W1975731151 @default.
- W3189331717 cites W1978615086 @default.
- W3189331717 cites W1980233381 @default.
- W3189331717 cites W1984698511 @default.
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- W3189331717 cites W2008293714 @default.
- W3189331717 cites W2008592872 @default.
- W3189331717 cites W2010699829 @default.
- W3189331717 cites W2015336562 @default.
- W3189331717 cites W2018445998 @default.
- W3189331717 cites W2019835459 @default.
- W3189331717 cites W2021264348 @default.
- W3189331717 cites W2022624614 @default.
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- W3189331717 cites W2024310762 @default.
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- W3189331717 cites W2050559247 @default.
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- W3189331717 cites W2154525100 @default.
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- W3189331717 doi "https://doi.org/10.3390/jof7080637" @default.
- W3189331717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8398874" @default.
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- W3189331717 hasPublicationYear "2021" @default.
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