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- W3189348836 abstract "Background: Immunotherapy and sorafenib exert anti-tumor effects through ferroptosis, but reliable biomarkers, based on the immune and ferroptosis status, are still lacking in hepatocellular carcinoma (HCC) for individual treatment and prognosis prediction.Methods: Ferroptosis-related genes (FRGs) were identified by downloading data from FerrDb and by searching and reading original articles from Pubmed. Immune-related genes (IRGs) were downloaded from ImmPort. Prognostic FRGs and IRGs were identified in the GSE14520 and the Cancer Genome Atlas (TCGA) data set. Least absolute shrinkage and selection operator (LASSO) Cox regression and multivariate Cox regression were used for model construction. Ferroptosis expression profile, infiltration of immune cells and somatic mutation status were analyzed and compared.Findings: 27 prognostic ferroptosis- and immune-related signatures were included to construct the comprehensive index of ferroptosis and immune (CIFI). A subgroup of patients was identified as having high CIFI, which was associated with worse prognosis. This subgroup had significantly up-regulated expression of many suppressors of ferroptosis and had higher fraction of immunosuppressive cells like cancer-associated fibroblasts (CAFs) and myeloid-derived suppressor cells (MDSCs). Notably, somatic mutation analysis indicated that high-CIFI patients had a higher level of tumor heterogeneity and higher mutation burden of genes like TP53.Interpretation: Our work developed a novel prognostic classifier based on ferroptosis and immune expression profiles in HCC, and this classifier could be used for prognostic prediction and to select patients for immunotherapies and targeted therapies. Funding Statement: This work is supported by the Youth Program of National Natural Science Foundation of China (Grant No. 81802940).Declaration of Interests: There are no interests to declare." @default.
- W3189348836 created "2021-08-16" @default.
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- W3189348836 date "2020-01-01" @default.
- W3189348836 modified "2023-10-06" @default.
- W3189348836 title "Development and Validation of a Combined Ferroptosis and Immune Prognostic Classifier for Hepatocellular Carcinoma" @default.
- W3189348836 doi "https://doi.org/10.2139/ssrn.3678770" @default.
- W3189348836 hasPublicationYear "2020" @default.
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