FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189372222> ?p ?o ?g. }

• W3189372222 endingPage "4025" @default.
• W3189372222 startingPage "4025" @default.
• W3189372222 abstract "The human telomerase is a key factor during tumorigenesis in prostate cancer (PCa). The androgen receptor (AR) is a key drug target controlling PCa growth and regulates hTERT expression, but is described to either inhibit or to activate. Here, we reveal that androgens repress and activate hTERT expression in a concentration-dependent manner. Physiological low androgen levels activate, while, notably, supraphysiological androgen levels (SAL), used in bipolar androgen therapy (BAT), repress hTERT expression. We confirmed the SAL-mediated gene repression of hTERT in PCa cell lines, native human PCa samples derived from patients treated ex vivo, as well as in cancer spheroids derived from androgen-dependent or castration resistant PCa (CRPC) cells. Interestingly, chromatin immuno-precipitation (ChIP) combined with functional assays revealed a positive (pARE) and a negative androgen response element (nARE). The nARE was narrowed down to 63 bp in the hTERT core promoter region. AR and tumor suppressors, inhibitor of growth 1 and 2 (ING1 and ING2, respectively), are androgen-dependently recruited. Mechanistically, knockdown indicates that ING1 and ING2 mediate AR-regulated transrepression. Thus, our data suggest an oppositional, biphasic function of AR to control the hTERT expression, while the inhibition of hTERT by androgens is mediated by the AR co-repressors ING1 and ING2." @default.
• W3189372222 created "2021-08-16" @default.
• W3189372222 creator A5013066091 @default.
• W3189372222 creator A5014648398 @default.
• W3189372222 creator A5023201544 @default.
• W3189372222 creator A5024731322 @default.
• W3189372222 creator A5035775368 @default.
• W3189372222 creator A5045336837 @default.
• W3189372222 creator A5047818246 @default.
• W3189372222 creator A5053283926 @default.
• W3189372222 creator A5057584400 @default.
• W3189372222 creator A5066148411 @default.
• W3189372222 creator A5068535122 @default.
• W3189372222 creator A5074556605 @default.
• W3189372222 creator A5074639104 @default.
• W3189372222 creator A5087458987 @default.
• W3189372222 creator A5089936859 @default.
• W3189372222 date "2021-08-10" @default.
• W3189372222 modified "2023-10-16" @default.
• W3189372222 title "Antithetic hTERT Regulation by Androgens in Prostate Cancer Cells: hTERT Inhibition Is Mediated by the ING1 and ING2 Tumor Suppressors" @default.
• W3189372222 cites W1968786809 @default.
• W3189372222 cites W1986948873 @default.
• W3189372222 cites W1997275472 @default.
• W3189372222 cites W2009846643 @default.
• W3189372222 cites W2011180717 @default.
• W3189372222 cites W2042179361 @default.
• W3189372222 cites W2046011405 @default.
• W3189372222 cites W2059286602 @default.
• W3189372222 cites W2062814633 @default.
• W3189372222 cites W2078484854 @default.
• W3189372222 cites W2108244474 @default.
• W3189372222 cites W2113544380 @default.
• W3189372222 cites W2120448591 @default.
• W3189372222 cites W2120757357 @default.
• W3189372222 cites W2123295754 @default.
• W3189372222 cites W2133021077 @default.
• W3189372222 cites W2145305345 @default.
• W3189372222 cites W2145898752 @default.
• W3189372222 cites W2147166694 @default.
• W3189372222 cites W2150881687 @default.
• W3189372222 cites W2172557341 @default.
• W3189372222 cites W2269476395 @default.
• W3189372222 cites W2306689997 @default.
• W3189372222 cites W2312048425 @default.
• W3189372222 cites W2434103263 @default.
• W3189372222 cites W2599630622 @default.
• W3189372222 cites W2772636479 @default.
• W3189372222 cites W2782270876 @default.
• W3189372222 cites W2888574118 @default.
• W3189372222 cites W2985185111 @default.
• W3189372222 cites W2987058388 @default.
• W3189372222 cites W2991171257 @default.
• W3189372222 cites W2999417355 @default.
• W3189372222 cites W3006879112 @default.
• W3189372222 cites W3027696696 @default.
• W3189372222 cites W3036283383 @default.
• W3189372222 cites W3145057554 @default.
• W3189372222 cites W4251408295 @default.
• W3189372222 doi "https://doi.org/10.3390/cancers13164025" @default.
• W3189372222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8391603" @default.
• W3189372222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34439179" @default.
• W3189372222 hasPublicationYear "2021" @default.
• W3189372222 type Work @default.
• W3189372222 sameAs 3189372222 @default.
• W3189372222 citedByCount "7" @default.
• W3189372222 countsByYear W31893722222021 @default.
• W3189372222 countsByYear W31893722222022 @default.
• W3189372222 countsByYear W31893722222023 @default.
• W3189372222 crossrefType "journal-article" @default.
• W3189372222 hasAuthorship W3189372222A5013066091 @default.
• W3189372222 hasAuthorship W3189372222A5014648398 @default.
• W3189372222 hasAuthorship W3189372222A5023201544 @default.
• W3189372222 hasAuthorship W3189372222A5024731322 @default.
• W3189372222 hasAuthorship W3189372222A5035775368 @default.
• W3189372222 hasAuthorship W3189372222A5045336837 @default.
• W3189372222 hasAuthorship W3189372222A5047818246 @default.
• W3189372222 hasAuthorship W3189372222A5053283926 @default.
• W3189372222 hasAuthorship W3189372222A5057584400 @default.
• W3189372222 hasAuthorship W3189372222A5066148411 @default.
• W3189372222 hasAuthorship W3189372222A5068535122 @default.
• W3189372222 hasAuthorship W3189372222A5074556605 @default.
• W3189372222 hasAuthorship W3189372222A5074639104 @default.
• W3189372222 hasAuthorship W3189372222A5087458987 @default.
• W3189372222 hasAuthorship W3189372222A5089936859 @default.
• W3189372222 hasBestOaLocation W31893722221 @default.
• W3189372222 hasConcept C101762097 @default.
• W3189372222 hasConcept C104317684 @default.
• W3189372222 hasConcept C121608353 @default.
• W3189372222 hasConcept C125593758 @default.
• W3189372222 hasConcept C134018914 @default.
• W3189372222 hasConcept C134320426 @default.
• W3189372222 hasConcept C150194340 @default.
• W3189372222 hasConcept C173396325 @default.
• W3189372222 hasConcept C185592680 @default.
• W3189372222 hasConcept C2777911890 @default.
• W3189372222 hasConcept C2780192828 @default.
• W3189372222 hasConcept C502942594 @default.
• W3189372222 hasConcept C54355233 @default.

• next