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• W3189388532 abstract "Abnormally high activity in the lateral habenula causes anxiety- or depression-like behaviours in animal experimental models. It has also been reported in humans that excessive stress in early life is correlated with the onset of psychiatric disorders in adults. These findings raise the question of whether maturation of the lateral habenula is affected under the influence of early-life experiences, which could govern behaviours throughout life.We examined the maturation of the lateral habenula in mice based on neuronal activity markers and plastic components: Zif268/Egr1, parvalbumin and perineuronal nets. We examined the effect of early-life stress using repeated maternal deprivation.First, we found a transient highly sensitive period of the lateral habenula under stress. The lateral habenula matured through 4 stages: postnatal days 1-9 (P1-9), P10-20, around P35 and after P35. At P10-20, the lateral habenula was highly sensitive to stress. We also observed experience-dependent maturation of the lateral habenula. Only mice exposed to chronic stress from P10-20 exhibited changes specific to the lateral habenula at P60: abnormally high stress reactivity shown by Zif268/Egr1 and fewer parvalbumin neurons. These mice showed anxiety- or depression-like behaviours in the light-dark box test and forced swim test.The effect of parvalbumin neurons in the lateral habenula on behavioural alterations remains unknown. It will be important to understand the sensitive period of the neuronal circuits in the lateral habenula and how the period P10-20 is different from P9 or earlier, or P35 or later.In mice, early-life stress in the period P10-20 led to late effects in adulthood: hyperactivity in the lateral habenula and anxiety or depression, indicating differences in neuronal plasticity between stages of lateral habenula maturation." @default.
• W3189388532 created "2021-08-16" @default.
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• W3189388532 date "2021-07-01" @default.
• W3189388532 modified "2023-10-01" @default.
• W3189388532 title "Early-life experiences altered the maturation of the lateral habenula in mouse models, resulting in behavioural disorders in adulthood" @default.
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• W3189388532 doi "https://doi.org/10.1503/jpn.200226" @default.
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