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• W3189402020 abstract "Abstract Background CD4 + T cell counts in certain human immunodeficiency virus (HIV)-infected patients called immunological non-responders (INRs) could not return to a normal level even with sustained antiretroviral therapy (ART) because of persistent immune activation, which is associated with pro-inflammatory cytokines production and an altered intestinal microbiome profile. Changes in gut bacterial composition have been linked to low CD4 + T cell counts in HIV-infected individuals. However, the association between CD4 + T cell counts and gut microbiota community composition and cytokines levels in INRs (CD4 + T cell counts < 500 cells/μL) from Yunnan Province, China, has not been previously investigated. Methods To address this issue, we carried out a cross-sectional study of 34 HIV-infected INRs. The patients were divided into CD4 count > 200 cells/μL group and CD4 count < 200 cells/μL group. The gut microbiota composition of each subject was analyzed by 16S rRNA gene sequencing. We also compared CD8 + T cell counts, pro-inflammatory cytokines levels, and nutritional status between the two groups. Results Compared to INRs with CD4 count > 200 cells/μL, those with CD4 count < 200 cells/μL had a lower CD4/CD8 ratio, lower nutritional status and higher serum levels of tumor necrosis factor (TNF)-α, interferon-γ-inducible protein (IP)-10 and interleukin (IL)-1α. Ruminococcaceae was less abundant in the CD4 count < 200 cells/μL group than in the CD4 count > 200 cells/μL group, and difference in alpha diversity was observed between the two groups. Moreover, CD4 + T cell counts were negatively associated with TNF-α and IL-1α levels and positively associated with the relative abundance of Ruminococcaceae . Conclusions Our study demonstrated that lower CD4 + T cell counts in INRs are associated with a reduced abundance of Ruminococcaceae in the gut and elevated serum pro-inflammatory cytokines levels. Thus, interventions targeting gut microbiota to increase CD4 + T cell counts are a potential strategy for promoting immune reconstitution in HIV-infected INRs." @default.
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• W3189402020 date "2021-08-03" @default.
• W3189402020 modified "2023-10-16" @default.
• W3189402020 title "Association between CD4+ T cell counts and gut microbiota and serum cytokines levels in HIV-infected immunological non-responders" @default.
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• W3189402020 doi "https://doi.org/10.1186/s12879-021-06491-z" @default.
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