Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189456876> ?p ?o ?g. }
- W3189456876 abstract "Abstract Colorectal cancer liver metastasis (CRCLM) has two major histopathological growth patterns: angiogenic desmoplastic and non-angiogenic replacement. The replacement lesions obtain their blood supply through vessel co-option, wherein the cancer cells hijack pre-existing blood vessels of the surrounding liver tissue. Consequentially, anti-angiogenic therapies are less efficacious in CRCLM patients with replacement lesions. However, the mechanisms which drive vessel co-option in the replacement lesions are unknown. Here, we show that Runt Related Transcription Factor-1 (RUNX1) overexpression in the cancer cells of the replacement lesions drives cancer cell motility via ARP2/3 to achieve vessel co-option. Furthermore, overexpression of RUNX1 in the cancer cells is mediated by Transforming Growth Factor Beta-1 (TGFβ1) and thrombospondin 1 (TSP1). Importantly, RUNX1 knockdown impaired the metastatic capability of colorectal cancer cells in vivo and induced the development of angiogenic lesions in liver. Our results confirm that RUNX1 may be a potential target to overcome vessel co-option in CRCLM." @default.
- W3189456876 created "2021-08-16" @default.
- W3189456876 creator A5020944754 @default.
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- W3189456876 creator A5060773546 @default.
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- W3189456876 creator A5081585291 @default.
- W3189456876 creator A5083606690 @default.
- W3189456876 creator A5085330220 @default.
- W3189456876 date "2021-08-10" @default.
- W3189456876 modified "2023-10-11" @default.
- W3189456876 title "Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases" @default.
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