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- W3189469541 endingPage "131741" @default.
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- W3189469541 abstract "Airborne particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs) and heavy metals (HMs) are significant contributors leading to many human health issues. Thus, this study was designed to perform chemical analysis and biological impact of airborne particulate matter 10 (PM10) in the World heritage City of Kandy City in Sri Lanka. 12 priority PAHs and 34 metals, including 10 highly toxic HMs were quantified. The biological effects of organic extracts were assayed using an in vitro primary porcine airway epithelial cell culture model. Cytotoxicity, DNA damage, and gene expressions of selected inflammatory and cancer-related genes were also assessed. Results showed that the total PAHs ranged from 3.062 to 36.887 ng/m3. The metals were dominated by Na > Ca > Mg > Al > K > Fe > Ti, while a few toxic HMs were much higher in the air than the existing ambient air quality standards. In the bioassays, a significant cytotoxicity (p < 0.05) was observed at 300 μg/mL treatment, and significant (p < 0.05) DNA damages were noted in all treatment groups. All genes assessed were found to be significantly up-regulated (p < 0.05) after 24 h of exposure and after 48 h, only TGF-β1 and p53 did not significantly up-regulate (p < 0.05). These findings confirm that the Kandy city air contains potential carcinogenic and mutagenic compounds and thus, exposure to Kandy air may increase the health risks and respiratory tract-related anomalies." @default.
- W3189469541 created "2021-08-16" @default.
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- W3189469541 date "2022-01-01" @default.
- W3189469541 modified "2023-10-13" @default.
- W3189469541 title "Characterization of airborne PAHs and metals associated with PM10 fractions collected from an urban area of Sri Lanka and the impact on airway epithelial cells." @default.
- W3189469541 cites W1503651890 @default.
- W3189469541 cites W1593059529 @default.
- W3189469541 cites W1663371441 @default.
- W3189469541 cites W1969623853 @default.
- W3189469541 cites W1970659346 @default.
- W3189469541 cites W1972703497 @default.
- W3189469541 cites W1974269960 @default.
- W3189469541 cites W1984009390 @default.
- W3189469541 cites W1984463643 @default.
- W3189469541 cites W1991028210 @default.
- W3189469541 cites W1991089571 @default.
- W3189469541 cites W1991455005 @default.
- W3189469541 cites W1994978280 @default.
- W3189469541 cites W2000893852 @default.
- W3189469541 cites W2003366520 @default.
- W3189469541 cites W2005497732 @default.
- W3189469541 cites W2007458878 @default.
- W3189469541 cites W2011731379 @default.
- W3189469541 cites W2016279964 @default.
- W3189469541 cites W2023383592 @default.
- W3189469541 cites W2023467953 @default.
- W3189469541 cites W2028314930 @default.
- W3189469541 cites W2033085616 @default.
- W3189469541 cites W2033236816 @default.
- W3189469541 cites W2038010507 @default.
- W3189469541 cites W2038490757 @default.
- W3189469541 cites W2038907545 @default.
- W3189469541 cites W2040239281 @default.
- W3189469541 cites W2044727267 @default.
- W3189469541 cites W2044824446 @default.
- W3189469541 cites W2050845857 @default.
- W3189469541 cites W2053634340 @default.
- W3189469541 cites W2056078688 @default.
- W3189469541 cites W2062015593 @default.
- W3189469541 cites W2069771063 @default.
- W3189469541 cites W2072056576 @default.
- W3189469541 cites W2073353075 @default.
- W3189469541 cites W2074070571 @default.
- W3189469541 cites W2074753456 @default.
- W3189469541 cites W2075642647 @default.
- W3189469541 cites W2076727125 @default.
- W3189469541 cites W2077440856 @default.
- W3189469541 cites W2080585042 @default.
- W3189469541 cites W2084629300 @default.
- W3189469541 cites W2089563615 @default.
- W3189469541 cites W2090776490 @default.
- W3189469541 cites W2092629964 @default.
- W3189469541 cites W2093775600 @default.
- W3189469541 cites W2096379616 @default.
- W3189469541 cites W2101438243 @default.
- W3189469541 cites W2102491352 @default.
- W3189469541 cites W2104786214 @default.
- W3189469541 cites W2104923992 @default.
- W3189469541 cites W2108079017 @default.
- W3189469541 cites W2114570899 @default.
- W3189469541 cites W2118614638 @default.
- W3189469541 cites W2120250658 @default.
- W3189469541 cites W2122808924 @default.
- W3189469541 cites W2129746956 @default.
- W3189469541 cites W2149755472 @default.
- W3189469541 cites W2164855027 @default.
- W3189469541 cites W2165011857 @default.
- W3189469541 cites W2166604768 @default.
- W3189469541 cites W2176258934 @default.
- W3189469541 cites W2195785268 @default.
- W3189469541 cites W2244755821 @default.
- W3189469541 cites W2256747721 @default.
- W3189469541 cites W2285627031 @default.
- W3189469541 cites W2288591399 @default.
- W3189469541 cites W2326405849 @default.
- W3189469541 cites W2334972472 @default.
- W3189469541 cites W2510979101 @default.
- W3189469541 cites W2580893451 @default.
- W3189469541 cites W2607350314 @default.
- W3189469541 cites W2776034268 @default.
- W3189469541 cites W2797842105 @default.
- W3189469541 cites W2804183353 @default.
- W3189469541 cites W2898712177 @default.
- W3189469541 cites W2943072218 @default.
- W3189469541 cites W2953463727 @default.
- W3189469541 cites W2975026841 @default.
- W3189469541 cites W2988562061 @default.
- W3189469541 cites W2994679067 @default.