Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189471820> ?p ?o ?g. }
- W3189471820 abstract "Background: Accurate diagnosis of skull base tumors is essential for providing personalized surgical treatment strategies. Intraoperative diagnosis can be challenging due to tumor diversity and lack of intraoperative pathology resources. Objective: To develop an independent and parallel intraoperative pathology workflow that can provide rapid and accurate skull base tumor diagnoses using label-free optical imaging and artificial intelligence (AI). Method: We used a fiber laser-based, label-free, non-consumptive, high-resolution microscopy method ($<$ 60 sec per 1 $times$ 1 mm$^text{2}$), called stimulated Raman histology (SRH), to image a consecutive, multicenter cohort of skull base tumor patients. SRH images were then used to train a convolutional neural network (CNN) model using three representation learning strategies: cross-entropy, self-supervised contrastive learning, and supervised contrastive learning. Our trained CNN models were tested on a held-out, multicenter SRH dataset. Results: SRH was able to image the diagnostic features of both benign and malignant skull base tumors. Of the three representation learning strategies, supervised contrastive learning most effectively learned the distinctive and diagnostic SRH image features for each of the skull base tumor types. In our multicenter testing set, cross-entropy achieved an overall diagnostic accuracy of 91.5%, self-supervised contrastive learning 83.9%, and supervised contrastive learning 96.6%. Our trained model was able to identify tumor-normal margins and detect regions of microscopic tumor infiltration in whole-slide SRH images. Conclusion: SRH with AI models trained using contrastive representation learning can provide rapid and accurate intraoperative diagnosis of skull base tumors." @default.
- W3189471820 created "2021-08-16" @default.
- W3189471820 creator A5004551167 @default.
- W3189471820 creator A5008573753 @default.
- W3189471820 creator A5008759858 @default.
- W3189471820 creator A5012603404 @default.
- W3189471820 creator A5021588104 @default.
- W3189471820 creator A5032969721 @default.
- W3189471820 creator A5039683673 @default.
- W3189471820 creator A5045110104 @default.
- W3189471820 creator A5045938099 @default.
- W3189471820 creator A5047510371 @default.
- W3189471820 creator A5050494156 @default.
- W3189471820 creator A5052775439 @default.
- W3189471820 creator A5056536623 @default.
- W3189471820 creator A5057445852 @default.
- W3189471820 creator A5059426494 @default.
- W3189471820 creator A5062724758 @default.
- W3189471820 creator A5064419280 @default.
- W3189471820 creator A5071674067 @default.
- W3189471820 creator A5077681153 @default.
- W3189471820 creator A5082052986 @default.
- W3189471820 creator A5083834388 @default.
- W3189471820 creator A5088446424 @default.
- W3189471820 date "2021-08-08" @default.
- W3189471820 modified "2023-09-27" @default.
- W3189471820 title "Contrastive Representation Learning for Rapid Intraoperative Diagnosis of Skull Base Tumors Imaged Using Stimulated Raman Histology." @default.
- W3189471820 cites W1711816339 @default.
- W3189471820 cites W1911377081 @default.
- W3189471820 cites W1936066510 @default.
- W3189471820 cites W2055507505 @default.
- W3189471820 cites W2103025101 @default.
- W3189471820 cites W2115318086 @default.
- W3189471820 cites W2121668219 @default.
- W3189471820 cites W2127710322 @default.
- W3189471820 cites W2137871970 @default.
- W3189471820 cites W2194775991 @default.
- W3189471820 cites W2557738935 @default.
- W3189471820 cites W2587305359 @default.
- W3189471820 cites W2760946358 @default.
- W3189471820 cites W2779448412 @default.
- W3189471820 cites W2801159924 @default.
- W3189471820 cites W2885688423 @default.
- W3189471820 cites W2947825023 @default.
- W3189471820 cites W2958086008 @default.
- W3189471820 cites W2998401461 @default.
- W3189471820 cites W3023089887 @default.
- W3189471820 cites W3034978746 @default.
- W3189471820 cites W3100345210 @default.
- W3189471820 cites W3159302505 @default.
- W3189471820 hasPublicationYear "2021" @default.
- W3189471820 type Work @default.
- W3189471820 sameAs 3189471820 @default.
- W3189471820 citedByCount "0" @default.
- W3189471820 crossrefType "posted-content" @default.
- W3189471820 hasAuthorship W3189471820A5004551167 @default.
- W3189471820 hasAuthorship W3189471820A5008573753 @default.
- W3189471820 hasAuthorship W3189471820A5008759858 @default.
- W3189471820 hasAuthorship W3189471820A5012603404 @default.
- W3189471820 hasAuthorship W3189471820A5021588104 @default.
- W3189471820 hasAuthorship W3189471820A5032969721 @default.
- W3189471820 hasAuthorship W3189471820A5039683673 @default.
- W3189471820 hasAuthorship W3189471820A5045110104 @default.
- W3189471820 hasAuthorship W3189471820A5045938099 @default.
- W3189471820 hasAuthorship W3189471820A5047510371 @default.
- W3189471820 hasAuthorship W3189471820A5050494156 @default.
- W3189471820 hasAuthorship W3189471820A5052775439 @default.
- W3189471820 hasAuthorship W3189471820A5056536623 @default.
- W3189471820 hasAuthorship W3189471820A5057445852 @default.
- W3189471820 hasAuthorship W3189471820A5059426494 @default.
- W3189471820 hasAuthorship W3189471820A5062724758 @default.
- W3189471820 hasAuthorship W3189471820A5064419280 @default.
- W3189471820 hasAuthorship W3189471820A5071674067 @default.
- W3189471820 hasAuthorship W3189471820A5077681153 @default.
- W3189471820 hasAuthorship W3189471820A5082052986 @default.
- W3189471820 hasAuthorship W3189471820A5083834388 @default.
- W3189471820 hasAuthorship W3189471820A5088446424 @default.
- W3189471820 hasConcept C108583219 @default.
- W3189471820 hasConcept C126838900 @default.
- W3189471820 hasConcept C141071460 @default.
- W3189471820 hasConcept C153180895 @default.
- W3189471820 hasConcept C154945302 @default.
- W3189471820 hasConcept C2779300802 @default.
- W3189471820 hasConcept C41008148 @default.
- W3189471820 hasConcept C534262118 @default.
- W3189471820 hasConcept C71924100 @default.
- W3189471820 hasConcept C81363708 @default.
- W3189471820 hasConceptScore W3189471820C108583219 @default.
- W3189471820 hasConceptScore W3189471820C126838900 @default.
- W3189471820 hasConceptScore W3189471820C141071460 @default.
- W3189471820 hasConceptScore W3189471820C153180895 @default.
- W3189471820 hasConceptScore W3189471820C154945302 @default.
- W3189471820 hasConceptScore W3189471820C2779300802 @default.
- W3189471820 hasConceptScore W3189471820C41008148 @default.
- W3189471820 hasConceptScore W3189471820C534262118 @default.
- W3189471820 hasConceptScore W3189471820C71924100 @default.
- W3189471820 hasConceptScore W3189471820C81363708 @default.
- W3189471820 hasLocation W31894718201 @default.
- W3189471820 hasOpenAccess W3189471820 @default.
- W3189471820 hasPrimaryLocation W31894718201 @default.