FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189644853> ?p ?o ?g. }

• W3189644853 abstract "ABSTRACT Nucleoside modified mRNA combined with Acuitas Therapeutics’ lipid nanoparticles (LNP) have been shown to support robust humoral immune responses in many preclinical animal vaccine studies and later in humans with the SARS-CoV-2 vaccination. We recently showed that this platform is highly inflammatory due to the LNPs’ ionizable lipid component. The inflammatory property is key to support the development of potent humoral immune responses. However, the mechanism by which this platform drives T follicular helper cells (Tfh) and humoral immune responses remains unknown. Here we show that lack of Langerhans cells or cDC1s neither significantly affected the induction of PR8 HA and SARS-CoV-2 RBD-specific Tfh cells and humoral immune responses, nor susceptibility towards the lethal challenge of influenza and SARS-CoV-2. However, the combined deletion of these two DC subsets led to a significant decrease in the induction of PR8 HA and SARS-CoV-2 RBD-specific Tfh cell and humoral immune responses. Despite these observed defects, the still high antibody titers were sufficient to confer protection towards lethal viral challenges. We further found that IL-6, but not neutrophils, was required to generate Tfh cells and antibody responses. In summary, here we bring evidence that the mRNA-LNP platform can support protective adaptive immune responses in the absence of specific DC subsets through an IL-6 dependent and neutrophil independent mechanism." @default.
• W3189644853 created "2021-08-16" @default.
• W3189644853 creator A5003608094 @default.
• W3189644853 creator A5018042323 @default.
• W3189644853 creator A5028970162 @default.
• W3189644853 creator A5044157623 @default.
• W3189644853 creator A5046491228 @default.
• W3189644853 creator A5057559654 @default.
• W3189644853 creator A5077919782 @default.
• W3189644853 creator A5087237101 @default.
• W3189644853 date "2021-08-02" @default.
• W3189644853 modified "2023-09-28" @default.
• W3189644853 title "Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 responses" @default.
• W3189644853 cites W1960924921 @default.
• W3189644853 cites W1974093371 @default.
• W3189644853 cites W1999300863 @default.
• W3189644853 cites W2018733478 @default.
• W3189644853 cites W2025980739 @default.
• W3189644853 cites W2043343078 @default.
• W3189644853 cites W2047366270 @default.
• W3189644853 cites W2058647478 @default.
• W3189644853 cites W2079574749 @default.
• W3189644853 cites W2091153004 @default.
• W3189644853 cites W2096166085 @default.
• W3189644853 cites W2110677178 @default.
• W3189644853 cites W2117985944 @default.
• W3189644853 cites W2141364024 @default.
• W3189644853 cites W2158491975 @default.
• W3189644853 cites W2161702641 @default.
• W3189644853 cites W2162970812 @default.
• W3189644853 cites W2166433840 @default.
• W3189644853 cites W2168028214 @default.
• W3189644853 cites W2208851958 @default.
• W3189644853 cites W221671807 @default.
• W3189644853 cites W2299705631 @default.
• W3189644853 cites W2320155654 @default.
• W3189644853 cites W2503169485 @default.
• W3189644853 cites W2540874117 @default.
• W3189644853 cites W2584249987 @default.
• W3189644853 cites W2610095823 @default.
• W3189644853 cites W2771277947 @default.
• W3189644853 cites W2788702215 @default.
• W3189644853 cites W2802953285 @default.
• W3189644853 cites W2885263529 @default.
• W3189644853 cites W2889321792 @default.
• W3189644853 cites W2946450286 @default.
• W3189644853 cites W2947424820 @default.
• W3189644853 cites W2995899440 @default.
• W3189644853 cites W3016350657 @default.
• W3189644853 cites W3043502363 @default.
• W3189644853 cites W3045596302 @default.
• W3189644853 cites W3083852020 @default.
• W3189644853 cites W3093367571 @default.
• W3189644853 cites W3133165021 @default.
• W3189644853 cites W3134328924 @default.
• W3189644853 cites W3135103990 @default.
• W3189644853 cites W3158786760 @default.
• W3189644853 cites W3162303048 @default.
• W3189644853 cites W3165142255 @default.
• W3189644853 cites W3166407960 @default.
• W3189644853 cites W3174110523 @default.
• W3189644853 cites W3177443097 @default.
• W3189644853 doi "https://doi.org/10.1101/2021.08.01.454662" @default.
• W3189644853 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8351776" @default.
• W3189644853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34373854" @default.
• W3189644853 hasPublicationYear "2021" @default.
• W3189644853 type Work @default.
• W3189644853 sameAs 3189644853 @default.
• W3189644853 citedByCount "1" @default.
• W3189644853 countsByYear W31896448532022 @default.
• W3189644853 crossrefType "posted-content" @default.
• W3189644853 hasAuthorship W3189644853A5003608094 @default.
• W3189644853 hasAuthorship W3189644853A5018042323 @default.
• W3189644853 hasAuthorship W3189644853A5028970162 @default.
• W3189644853 hasAuthorship W3189644853A5044157623 @default.
• W3189644853 hasAuthorship W3189644853A5046491228 @default.
• W3189644853 hasAuthorship W3189644853A5057559654 @default.
• W3189644853 hasAuthorship W3189644853A5077919782 @default.
• W3189644853 hasAuthorship W3189644853A5087237101 @default.
• W3189644853 hasBestOaLocation W31896448531 @default.
• W3189644853 hasConcept C136449434 @default.
• W3189644853 hasConcept C159047783 @default.
• W3189644853 hasConcept C159654299 @default.
• W3189644853 hasConcept C193419808 @default.
• W3189644853 hasConcept C203014093 @default.
• W3189644853 hasConcept C2776548049 @default.
• W3189644853 hasConcept C2776709828 @default.
• W3189644853 hasConcept C2779836521 @default.
• W3189644853 hasConcept C86803240 @default.
• W3189644853 hasConcept C8891405 @default.
• W3189644853 hasConceptScore W3189644853C136449434 @default.
• W3189644853 hasConceptScore W3189644853C159047783 @default.
• W3189644853 hasConceptScore W3189644853C159654299 @default.
• W3189644853 hasConceptScore W3189644853C193419808 @default.
• W3189644853 hasConceptScore W3189644853C203014093 @default.
• W3189644853 hasConceptScore W3189644853C2776548049 @default.
• W3189644853 hasConceptScore W3189644853C2776709828 @default.
• W3189644853 hasConceptScore W3189644853C2779836521 @default.
• W3189644853 hasConceptScore W3189644853C86803240 @default.
• W3189644853 hasConceptScore W3189644853C8891405 @default.

• next