Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189654990> ?p ?o ?g. }
- W3189654990 endingPage "750" @default.
- W3189654990 startingPage "750" @default.
- W3189654990 abstract "We report herein the evaluation of various pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines as potential cytotoxic agents. These molecules were obtained by developing the multicomponent Groebke–Blackburn–Bienaymé reaction to yield various pyrido[2′,1′:2,3]imidazo[4,5-c]quinolines which are isosteres of ellipticine whose biological activities are well established. To evaluate the anticancer potential of these pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amine derivatives in the human neuroblastoma cell line, the cytotoxicity was examined using the WST-1 assay after 72 h drug exposure. A clonogenic assay was used to assess the ability of treated cells to proliferate and form colonies. Protein expressions (Bax, bcl-2, cleaved caspase-3, cleaved PARP-1) were analyzed using Western blotting. The colony number decrease in cells was 50.54%, 37.88% and 27.12% following exposure to compounds 2d, 2g and 4b respectively at 10 μM. We also show that treating the neuroblastoma cell line with these compounds resulted in a significant alteration in caspase-3 and PARP-1 cleavage." @default.
- W3189654990 created "2021-08-16" @default.
- W3189654990 creator A5008109281 @default.
- W3189654990 creator A5009465420 @default.
- W3189654990 creator A5040143445 @default.
- W3189654990 creator A5064456030 @default.
- W3189654990 creator A5065222117 @default.
- W3189654990 creator A5071466971 @default.
- W3189654990 creator A5071628101 @default.
- W3189654990 creator A5074098589 @default.
- W3189654990 date "2021-07-30" @default.
- W3189654990 modified "2023-09-24" @default.
- W3189654990 title "Pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5-amines as Potential Cytotoxic Agents against Human Neuroblastoma" @default.
- W3189654990 cites W1970246741 @default.
- W3189654990 cites W1970868906 @default.
- W3189654990 cites W1972246768 @default.
- W3189654990 cites W1975197349 @default.
- W3189654990 cites W1979883744 @default.
- W3189654990 cites W1985917494 @default.
- W3189654990 cites W1998811109 @default.
- W3189654990 cites W2000036538 @default.
- W3189654990 cites W2004873033 @default.
- W3189654990 cites W2005216658 @default.
- W3189654990 cites W2016571876 @default.
- W3189654990 cites W2028956268 @default.
- W3189654990 cites W2046159574 @default.
- W3189654990 cites W2046349840 @default.
- W3189654990 cites W2070907454 @default.
- W3189654990 cites W2081145901 @default.
- W3189654990 cites W2081613128 @default.
- W3189654990 cites W2089662609 @default.
- W3189654990 cites W2095296988 @default.
- W3189654990 cites W2105668062 @default.
- W3189654990 cites W2117692326 @default.
- W3189654990 cites W2130439645 @default.
- W3189654990 cites W2130465135 @default.
- W3189654990 cites W2130697764 @default.
- W3189654990 cites W2134967712 @default.
- W3189654990 cites W2151982148 @default.
- W3189654990 cites W2157952351 @default.
- W3189654990 cites W2160030461 @default.
- W3189654990 cites W2169703537 @default.
- W3189654990 cites W2179584225 @default.
- W3189654990 cites W2315515352 @default.
- W3189654990 cites W2490739915 @default.
- W3189654990 cites W2525864328 @default.
- W3189654990 cites W2736866932 @default.
- W3189654990 cites W2915052615 @default.
- W3189654990 cites W2949975250 @default.
- W3189654990 cites W2952673290 @default.
- W3189654990 cites W2953295938 @default.
- W3189654990 cites W2969312892 @default.
- W3189654990 cites W2974870150 @default.
- W3189654990 cites W4230225850 @default.
- W3189654990 cites W80462140 @default.
- W3189654990 doi "https://doi.org/10.3390/ph14080750" @default.
- W3189654990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8399734" @default.
- W3189654990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34451847" @default.
- W3189654990 hasPublicationYear "2021" @default.
- W3189654990 type Work @default.
- W3189654990 sameAs 3189654990 @default.
- W3189654990 citedByCount "0" @default.
- W3189654990 crossrefType "journal-article" @default.
- W3189654990 hasAuthorship W3189654990A5008109281 @default.
- W3189654990 hasAuthorship W3189654990A5009465420 @default.
- W3189654990 hasAuthorship W3189654990A5040143445 @default.
- W3189654990 hasAuthorship W3189654990A5064456030 @default.
- W3189654990 hasAuthorship W3189654990A5065222117 @default.
- W3189654990 hasAuthorship W3189654990A5071466971 @default.
- W3189654990 hasAuthorship W3189654990A5071628101 @default.
- W3189654990 hasAuthorship W3189654990A5074098589 @default.
- W3189654990 hasBestOaLocation W31896549901 @default.
- W3189654990 hasConcept C109316439 @default.
- W3189654990 hasConcept C117262875 @default.
- W3189654990 hasConcept C131779359 @default.
- W3189654990 hasConcept C153911025 @default.
- W3189654990 hasConcept C154317977 @default.
- W3189654990 hasConcept C178790620 @default.
- W3189654990 hasConcept C182979987 @default.
- W3189654990 hasConcept C185592680 @default.
- W3189654990 hasConcept C190283241 @default.
- W3189654990 hasConcept C202751555 @default.
- W3189654990 hasConcept C2776715637 @default.
- W3189654990 hasConcept C54355233 @default.
- W3189654990 hasConcept C552990157 @default.
- W3189654990 hasConcept C55493867 @default.
- W3189654990 hasConcept C71240020 @default.
- W3189654990 hasConcept C81885089 @default.
- W3189654990 hasConcept C82381507 @default.
- W3189654990 hasConcept C86803240 @default.
- W3189654990 hasConcept C98274493 @default.
- W3189654990 hasConceptScore W3189654990C109316439 @default.
- W3189654990 hasConceptScore W3189654990C117262875 @default.
- W3189654990 hasConceptScore W3189654990C131779359 @default.
- W3189654990 hasConceptScore W3189654990C153911025 @default.
- W3189654990 hasConceptScore W3189654990C154317977 @default.
- W3189654990 hasConceptScore W3189654990C178790620 @default.
- W3189654990 hasConceptScore W3189654990C182979987 @default.