Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189698745> ?p ?o ?g. }
- W3189698745 abstract "Vibrio campbellii is a Gram-negative bacterium that is free-living and ubiquitous in marine environments, and it is a pathogen of fish and shellfish. Swimming motility via a single polar flagellum is a critical virulence factor in V. campbellii pathogenesis, and disruption of the flagellar motor significantly decreases host mortality. To examine V. campbellii flagellar gene regulation, we identified homologs of flagellar and chemotaxis genes conserved in other members of the Vibrionaceae and determined the transcriptional profile of these loci using differential RNA-seq. We systematically deleted all 63 predicted flagellar and chemotaxis genes in V. campbellii and examined their effects on motility and flagellum production. We specifically focused on the core flagellar regulators of the flagellar regulatory hierarchy established in other Vibrios: RpoN (σ54), FlrA, FlrC, and FliA. Our results show that V. campbellii transcription of flagellar and chemotaxis genes is governed by a multi-tiered regulatory hierarchy similar to other motile Vibrio species but with two critical differences: the σ54-dependent regulator FlrA is dispensable for motility, and Class II gene expression is independent of σ54 regulation. Our genetic and phenotypic dissection of the V. campbellii flagellar regulatory network highlights the differences that have evolved in flagellar regulation across the Vibrionaceae." @default.
- W3189698745 created "2021-08-16" @default.
- W3189698745 creator A5032177689 @default.
- W3189698745 creator A5034349178 @default.
- W3189698745 creator A5046604410 @default.
- W3189698745 creator A5051764384 @default.
- W3189698745 creator A5055141583 @default.
- W3189698745 creator A5068808757 @default.
- W3189698745 creator A5068933942 @default.
- W3189698745 creator A5084100848 @default.
- W3189698745 date "2021-05-10" @default.
- W3189698745 modified "2023-09-26" @default.
- W3189698745 title "The polar flagellar transcriptional regulatory network in Vibrio campbellii deviates from canonical Vibrio species" @default.
- W3189698745 cites W1489973623 @default.
- W3189698745 cites W1551665537 @default.
- W3189698745 cites W1824708390 @default.
- W3189698745 cites W1906978066 @default.
- W3189698745 cites W1949420093 @default.
- W3189698745 cites W1971008206 @default.
- W3189698745 cites W1976578567 @default.
- W3189698745 cites W1984586183 @default.
- W3189698745 cites W1992841053 @default.
- W3189698745 cites W2003727205 @default.
- W3189698745 cites W2023174588 @default.
- W3189698745 cites W2023944916 @default.
- W3189698745 cites W2026881966 @default.
- W3189698745 cites W2032960973 @default.
- W3189698745 cites W2037300459 @default.
- W3189698745 cites W2039028645 @default.
- W3189698745 cites W2043533338 @default.
- W3189698745 cites W2058989497 @default.
- W3189698745 cites W2064647937 @default.
- W3189698745 cites W2077739444 @default.
- W3189698745 cites W2082075348 @default.
- W3189698745 cites W2085958426 @default.
- W3189698745 cites W2086869063 @default.
- W3189698745 cites W2099399224 @default.
- W3189698745 cites W2105240801 @default.
- W3189698745 cites W2105712092 @default.
- W3189698745 cites W2109216140 @default.
- W3189698745 cites W2110071696 @default.
- W3189698745 cites W2111997657 @default.
- W3189698745 cites W2119464713 @default.
- W3189698745 cites W2130574269 @default.
- W3189698745 cites W2136424697 @default.
- W3189698745 cites W2137871890 @default.
- W3189698745 cites W2139697588 @default.
- W3189698745 cites W2140356897 @default.
- W3189698745 cites W2142233839 @default.
- W3189698745 cites W2144528883 @default.
- W3189698745 cites W2145845306 @default.
- W3189698745 cites W2146299801 @default.
- W3189698745 cites W2148915230 @default.
- W3189698745 cites W2149311070 @default.
- W3189698745 cites W2154559576 @default.
- W3189698745 cites W2156125289 @default.
- W3189698745 cites W2157573672 @default.
- W3189698745 cites W2157812225 @default.
- W3189698745 cites W2160015949 @default.
- W3189698745 cites W2160433271 @default.
- W3189698745 cites W2161782181 @default.
- W3189698745 cites W2162063363 @default.
- W3189698745 cites W2164485511 @default.
- W3189698745 cites W2165077100 @default.
- W3189698745 cites W2168063573 @default.
- W3189698745 cites W2169576145 @default.
- W3189698745 cites W2399664311 @default.
- W3189698745 cites W2568577966 @default.
- W3189698745 cites W2582624089 @default.
- W3189698745 cites W2604460446 @default.
- W3189698745 cites W2790170641 @default.
- W3189698745 cites W2985567791 @default.
- W3189698745 cites W2997681387 @default.
- W3189698745 cites W3014137574 @default.
- W3189698745 cites W3028082238 @default.
- W3189698745 cites W3089821039 @default.
- W3189698745 cites W906901795 @default.
- W3189698745 doi "https://doi.org/10.1101/2021.05.10.443453" @default.
- W3189698745 hasPublicationYear "2021" @default.
- W3189698745 type Work @default.
- W3189698745 sameAs 3189698745 @default.
- W3189698745 citedByCount "1" @default.
- W3189698745 countsByYear W31896987452021 @default.
- W3189698745 crossrefType "posted-content" @default.
- W3189698745 hasAuthorship W3189698745A5032177689 @default.
- W3189698745 hasAuthorship W3189698745A5034349178 @default.
- W3189698745 hasAuthorship W3189698745A5046604410 @default.
- W3189698745 hasAuthorship W3189698745A5051764384 @default.
- W3189698745 hasAuthorship W3189698745A5055141583 @default.
- W3189698745 hasAuthorship W3189698745A5068808757 @default.
- W3189698745 hasAuthorship W3189698745A5068933942 @default.
- W3189698745 hasAuthorship W3189698745A5084100848 @default.
- W3189698745 hasBestOaLocation W31896987451 @default.
- W3189698745 hasConcept C104317684 @default.
- W3189698745 hasConcept C115811362 @default.
- W3189698745 hasConcept C170493617 @default.
- W3189698745 hasConcept C2776154503 @default.
- W3189698745 hasConcept C2776422119 @default.
- W3189698745 hasConcept C523546767 @default.
- W3189698745 hasConcept C54166955 @default.