FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189756332> ?p ?o ?g. }

• W3189756332 abstract "Growing evidence argues for a relationship between liver and bone metabolisms. Sclerostin is a secreted glycoprotein and could antagonize osteoblast-mediated bone formation. Previous studies indicated that circulating sclerostin levels may be associated with metabolic parameters with inconsistent results. This study was designed to evaluate serum sclerostin in patients with or without nonalcoholic fatty liver disease (NAFLD) and to analyze its relationship with metabolic parameters in different populations.A cross-sectional study was designed and 168 NAFLD subjects and 85 control subjects were included in this study. Serum sclerostin and metabolic parameters were measured. Mouse models of NAFLD were also induced by high-fat diet. Bone structural parameters were determined using microCT and mRNA expression levels of sclerostin in bone and liver tissues were measured.Our study suggested that circulating sclerostin levels were significantly lower in NAFLD subjects compared with normal controls. In NAFLD subjects, sclerostin was negatively correlated with multiple metabolic parameters, including waist circumference, urea, hepatic enzyme, gamma-glutamyl transpeptidase, and triglyceride, while such correlation was not significant in control subjects. Circulating sclerostin was also negatively correlated with fatty liver index in NAFLD subjects but not in control subjects. Mice fed on a high-fat diet had reduced bone mass and lower sclerostin expression levels in both the bone and liver tissues.Our study suggested that the liver-lipid-bone interactions may play a key role in the abnormal bone metabolism in NAFLD, and circulating sclerostin may be a surrogate marker to reflect bone metabolism status in NAFLD subjects." @default.
• W3189756332 created "2021-08-16" @default.
• W3189756332 creator A5003642180 @default.
• W3189756332 creator A5042937887 @default.
• W3189756332 creator A5065989510 @default.
• W3189756332 creator A5071215161 @default.
• W3189756332 creator A5075311149 @default.
• W3189756332 creator A5076768386 @default.
• W3189756332 creator A5085639572 @default.
• W3189756332 date "2021-08-05" @default.
• W3189756332 modified "2023-10-17" @default.
• W3189756332 title "Decreased Sclerostin Secretion in Humans and Mice With Nonalcoholic Fatty Liver Disease" @default.
• W3189756332 cites W1536440494 @default.
• W3189756332 cites W1540165847 @default.
• W3189756332 cites W1567552957 @default.
• W3189756332 cites W1955614201 @default.
• W3189756332 cites W1974413125 @default.
• W3189756332 cites W1992208052 @default.
• W3189756332 cites W2037750372 @default.
• W3189756332 cites W2076938286 @default.
• W3189756332 cites W2081840501 @default.
• W3189756332 cites W2103505662 @default.
• W3189756332 cites W2111946630 @default.
• W3189756332 cites W2160405233 @default.
• W3189756332 cites W2194162502 @default.
• W3189756332 cites W2199988108 @default.
• W3189756332 cites W2511601658 @default.
• W3189756332 cites W2521924389 @default.
• W3189756332 cites W2552127252 @default.
• W3189756332 cites W2605826086 @default.
• W3189756332 cites W2613909859 @default.
• W3189756332 cites W2766152325 @default.
• W3189756332 cites W2794172042 @default.
• W3189756332 cites W2807030960 @default.
• W3189756332 cites W2894758253 @default.
• W3189756332 cites W2896330481 @default.
• W3189756332 cites W2912818529 @default.
• W3189756332 cites W2951814941 @default.
• W3189756332 cites W562961015 @default.
• W3189756332 doi "https://doi.org/10.3389/fendo.2021.707505" @default.
• W3189756332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8374147" @default.
• W3189756332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34421825" @default.
• W3189756332 hasPublicationYear "2021" @default.
• W3189756332 type Work @default.
• W3189756332 sameAs 3189756332 @default.
• W3189756332 citedByCount "6" @default.
• W3189756332 countsByYear W31897563322022 @default.
• W3189756332 countsByYear W31897563322023 @default.
• W3189756332 crossrefType "journal-article" @default.
• W3189756332 hasAuthorship W3189756332A5003642180 @default.
• W3189756332 hasAuthorship W3189756332A5042937887 @default.
• W3189756332 hasAuthorship W3189756332A5065989510 @default.
• W3189756332 hasAuthorship W3189756332A5071215161 @default.
• W3189756332 hasAuthorship W3189756332A5075311149 @default.
• W3189756332 hasAuthorship W3189756332A5076768386 @default.
• W3189756332 hasAuthorship W3189756332A5085639572 @default.
• W3189756332 hasBestOaLocation W31897563321 @default.
• W3189756332 hasConcept C126322002 @default.
• W3189756332 hasConcept C134018914 @default.
• W3189756332 hasConcept C137620995 @default.
• W3189756332 hasConcept C170033053 @default.
• W3189756332 hasConcept C2776954865 @default.
• W3189756332 hasConcept C2778772119 @default.
• W3189756332 hasConcept C2779134260 @default.
• W3189756332 hasConcept C2779277721 @default.
• W3189756332 hasConcept C55493867 @default.
• W3189756332 hasConcept C62478195 @default.
• W3189756332 hasConcept C71924100 @default.
• W3189756332 hasConcept C86803240 @default.
• W3189756332 hasConceptScore W3189756332C126322002 @default.
• W3189756332 hasConceptScore W3189756332C134018914 @default.
• W3189756332 hasConceptScore W3189756332C137620995 @default.
• W3189756332 hasConceptScore W3189756332C170033053 @default.
• W3189756332 hasConceptScore W3189756332C2776954865 @default.
• W3189756332 hasConceptScore W3189756332C2778772119 @default.
• W3189756332 hasConceptScore W3189756332C2779134260 @default.
• W3189756332 hasConceptScore W3189756332C2779277721 @default.
• W3189756332 hasConceptScore W3189756332C55493867 @default.
• W3189756332 hasConceptScore W3189756332C62478195 @default.
• W3189756332 hasConceptScore W3189756332C71924100 @default.
• W3189756332 hasConceptScore W3189756332C86803240 @default.
• W3189756332 hasLocation W31897563321 @default.
• W3189756332 hasLocation W31897563322 @default.
• W3189756332 hasLocation W31897563323 @default.
• W3189756332 hasOpenAccess W3189756332 @default.
• W3189756332 hasPrimaryLocation W31897563321 @default.
• W3189756332 hasRelatedWork W1884609619 @default.
• W3189756332 hasRelatedWork W1967422973 @default.
• W3189756332 hasRelatedWork W1973843004 @default.
• W3189756332 hasRelatedWork W1975979596 @default.
• W3189756332 hasRelatedWork W2022695623 @default.
• W3189756332 hasRelatedWork W2041938128 @default.
• W3189756332 hasRelatedWork W2105853087 @default.
• W3189756332 hasRelatedWork W2128714854 @default.
• W3189756332 hasRelatedWork W2160818938 @default.
• W3189756332 hasRelatedWork W2964737734 @default.
• W3189756332 hasVolume "12" @default.
• W3189756332 isParatext "false" @default.
• W3189756332 isRetracted "false" @default.
• W3189756332 magId "3189756332" @default.

• next