FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189777744> ?p ?o ?g. }

• W3189777744 endingPage "156" @default.
• W3189777744 startingPage "144" @default.
• W3189777744 abstract "Ionizing radiation (IR)-induced excessive reactive oxygen species (ROS) is an important contributor of the injury of hematopoietic system. Grape seed proanthocyanidin extract (GSPE) is a new type of antioxidant, whereas whether it could ameliorate IR-induced hematopoietic injury remains unclear. Here, we show that GSPE treatment improves the survival of irradiated mice and alleviates IR-induced myelosuppression. Meanwhile, the hematopoietic reconstituting ability of hematopoietic stem cells (HSCs) in mice following irradiation exposure is significantly increased after GSPE treatment. Furthermore, GSPE treatment can reduce IR-induced ROS production and relieve DNA damage and apoptosis in hematopoietic stem progenitor cells (HSPCs). Interestingly, we find that a critical antioxidant-associated gene fokhead box transcription factor O1 (Foxo1) is significantly decreased in HSPCs after irradiation. Consistently, hematopoietic specific deletion of Foxo1 increases the radiosensitivity of mice. Further investigations reveal that GSPE treatment specifically upregulates the expression of Foxo1, as well as its target genes superoxide dismutase 1 (SOD1), superoxide dismutase 2 (SOD2) and catalase (CAT). Importantly, Foxo1 deficiency largely abolishes the radioprotection of GSPE on HSPCs. Collectively, our data demonstrate that GSPE plays an important role in ameliorating IR-induced HSPC injury via the Foxo1-mediated pathway. Therefore, GSPE may be used as a promising radioprotective agent." @default.
• W3189777744 created "2021-08-16" @default.
• W3189777744 creator A5001629068 @default.
• W3189777744 creator A5003377806 @default.
• W3189777744 creator A5005426960 @default.
• W3189777744 creator A5010664944 @default.
• W3189777744 creator A5034808877 @default.
• W3189777744 creator A5036956800 @default.
• W3189777744 creator A5040931420 @default.
• W3189777744 creator A5043858190 @default.
• W3189777744 creator A5053815236 @default.
• W3189777744 creator A5056522759 @default.
• W3189777744 creator A5060964483 @default.
• W3189777744 creator A5064363137 @default.
• W3189777744 creator A5066228329 @default.
• W3189777744 creator A5067740612 @default.
• W3189777744 creator A5068373797 @default.
• W3189777744 date "2021-10-01" @default.
• W3189777744 modified "2023-10-15" @default.
• W3189777744 title "Grape seed proanthocyanidin extract ameliorates ionizing radiation-induced hematopoietic stem progenitor cell injury by regulating Foxo1 in mice" @default.
• W3189777744 cites W1963793703 @default.
• W3189777744 cites W1967829518 @default.
• W3189777744 cites W1969544207 @default.
• W3189777744 cites W1982071626 @default.
• W3189777744 cites W1983112429 @default.
• W3189777744 cites W1985999015 @default.
• W3189777744 cites W1992336853 @default.
• W3189777744 cites W1992407127 @default.
• W3189777744 cites W1994990671 @default.
• W3189777744 cites W1995948316 @default.
• W3189777744 cites W2008223253 @default.
• W3189777744 cites W2008484243 @default.
• W3189777744 cites W2010916683 @default.
• W3189777744 cites W2011295880 @default.
• W3189777744 cites W2012830812 @default.
• W3189777744 cites W2035527882 @default.
• W3189777744 cites W2044723012 @default.
• W3189777744 cites W2045906656 @default.
• W3189777744 cites W2045907249 @default.
• W3189777744 cites W2046104275 @default.
• W3189777744 cites W2057485681 @default.
• W3189777744 cites W2059751754 @default.
• W3189777744 cites W2077560838 @default.
• W3189777744 cites W2097273693 @default.
• W3189777744 cites W2110596984 @default.
• W3189777744 cites W2116043907 @default.
• W3189777744 cites W2176847484 @default.
• W3189777744 cites W2302719675 @default.
• W3189777744 cites W2331201236 @default.
• W3189777744 cites W2346512117 @default.
• W3189777744 cites W2517833681 @default.
• W3189777744 cites W2581034246 @default.
• W3189777744 cites W2591443307 @default.
• W3189777744 cites W2623456620 @default.
• W3189777744 cites W2755129162 @default.
• W3189777744 cites W2787794728 @default.
• W3189777744 cites W2791564057 @default.
• W3189777744 cites W2802543878 @default.
• W3189777744 cites W2810696819 @default.
• W3189777744 cites W2897540875 @default.
• W3189777744 cites W2901501609 @default.
• W3189777744 cites W2909456588 @default.
• W3189777744 cites W2915935834 @default.
• W3189777744 cites W2920927997 @default.
• W3189777744 cites W2934635783 @default.
• W3189777744 cites W2942745234 @default.
• W3189777744 cites W2948406972 @default.
• W3189777744 cites W2970306291 @default.
• W3189777744 cites W2996734517 @default.
• W3189777744 cites W3016777912 @default.
• W3189777744 cites W4236445721 @default.
• W3189777744 doi "https://doi.org/10.1016/j.freeradbiomed.2021.08.010" @default.
• W3189777744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34389464" @default.
• W3189777744 hasPublicationYear "2021" @default.
• W3189777744 type Work @default.
• W3189777744 sameAs 3189777744 @default.
• W3189777744 citedByCount "5" @default.
• W3189777744 countsByYear W31897777442022 @default.
• W3189777744 countsByYear W31897777442023 @default.
• W3189777744 crossrefType "journal-article" @default.
• W3189777744 hasAuthorship W3189777744A5001629068 @default.
• W3189777744 hasAuthorship W3189777744A5003377806 @default.
• W3189777744 hasAuthorship W3189777744A5005426960 @default.
• W3189777744 hasAuthorship W3189777744A5010664944 @default.
• W3189777744 hasAuthorship W3189777744A5034808877 @default.
• W3189777744 hasAuthorship W3189777744A5036956800 @default.
• W3189777744 hasAuthorship W3189777744A5040931420 @default.
• W3189777744 hasAuthorship W3189777744A5043858190 @default.
• W3189777744 hasAuthorship W3189777744A5053815236 @default.
• W3189777744 hasAuthorship W3189777744A5056522759 @default.
• W3189777744 hasAuthorship W3189777744A5060964483 @default.
• W3189777744 hasAuthorship W3189777744A5064363137 @default.
• W3189777744 hasAuthorship W3189777744A5066228329 @default.
• W3189777744 hasAuthorship W3189777744A5067740612 @default.
• W3189777744 hasAuthorship W3189777744A5068373797 @default.
• W3189777744 hasConcept C109159458 @default.
• W3189777744 hasConcept C140149449 @default.
• W3189777744 hasConcept C143425029 @default.

• next