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• W3189777777 abstract "The physical and clinical constraints surrounding diffusion-weighted imaging (DWI) often limit the spatial resolution of the produced images to voxels up to eight times larger than those of T1w images. The detailed information contained in accessible high-resolution T1w images could help in the synthesis of diffusion images with a greater level of detail. However, the non-Euclidean nature of diffusion imaging hinders current deep generative models from synthesizing physically plausible images. In this work, we propose the first Riemannian network architecture for the direct generation of diffusion tensors (DT) and diffusion orientation distribution functions (dODFs) from high-resolution T1w images. Our integration of the log-Euclidean Metric into a learning objective guarantees, unlike standard Euclidean networks, the mathematically-valid synthesis of diffusion. Furthermore, our approach improves the fractional anisotropy mean squared error (FA MSE) between the synthesized diffusion and the ground-truth by more than 23% and the cosine similarity between principal directions by almost 5% when compared to our baselines. We validate our generated diffusion by comparing the resulting tractograms to our expected real data. We observe similar fiber bundles with streamlines having <3% difference in length, <1% difference in volume, and a visually close shape. While our method is able to generate diffusion images from structural inputs in a high-resolution space within 15 s, we acknowledge and discuss the limits of diffusion inference solely relying on T1w images. Our results nonetheless suggest a relationship between the high-level geometry of the brain and its overall white matter architecture that remains to be explored." @default.
• W3189777777 created "2021-08-16" @default.
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• W3189777777 date "2022-09-08" @default.
• W3189777777 modified "2023-10-05" @default.
• W3189777777 title "Manifold-aware synthesis of high-resolution diffusion from structural imaging" @default.
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• W3189777777 doi "https://doi.org/10.3389/fnimg.2022.930496" @default.
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• W3189777777 hasPublicationYear "2022" @default.
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